Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

The reconsolidation hypothesis posits that the presentation of a specific cue, previously associated with a life event, makes the stored memory pass from a stable to a reactivated state. In this state, memory is again labile and susceptible to different agents, which may either damage or improve the original memory. Such susceptibility decreases over time and leads to a re-stabilization phase known as reconsolidation process. This process has been assigned two biological roles: memory updating, which suggests that destabilization of the original memory allows the integration of new information into the background of the original memory; and memory strengthening, which postulates that the labilization-reconsolidation process strengthens the original memory. The aim of this review is to analyze the strengthening as an improvement obtained only by triggering such process without any other treatment. In our lab, we have demonstrated that when triggering the labilization-reconsolidation process at least once the original memory becomes strengthened and increases its persistence. We have also shown that repeated labilization-reconsolidation processes strengthened the original memory by enlarging its precision, and said reinforced memories were more resistant to interference. Finally, we have shown that the strengthening function is not operative in older memories. We present and discuss both our findings and those of others, trying to reveal the central role of reconsolidation in the modification of stored information. © 2014 Elsevier Ltd.

Registro:

Documento: Artículo
Título:Strengthening a consolidated memory: The key role of the reconsolidation process
Autor:Forcato, C.; Fernandez, R.S.; Pedreira, M.E.
Filiación:Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE - CONICET, Ciudad Universitaria, Pab. II, Buenos Aires, 1428, Argentina
Department of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany
Palabras clave:Declarative memory; Memory reconsolidation; Mismatch; Strengthening function; Translational applications; n methyl dextro aspartic acid receptor; accuracy; amnesia; cognition; cognitive rehabilitation; declarative memory; drug dependence; episodic memory; GABAergic system; human; learning; memory; memory consolidation; memory disorder; memory reconsolidation; memory strengthening; mental performance; neuromodulation; nonhuman; reinforcement; Review; stress; animal; long term memory; memory; physiology; recall; time; Animals; Humans; Memory; Mental Recall; Retention (Psychology); Time Factors
Año:2014
Volumen:108
Número:4-6
Página de inicio:323
Página de fin:333
DOI: http://dx.doi.org/10.1016/j.jphysparis.2014.09.001
Título revista:Journal of Physiology Paris
Título revista abreviado:J. Physiol. Paris
ISSN:09284257
CODEN:JHYSE
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n4-6_p323_Forcato

Referencias:

  • Agren, T., Engman, J., Frick, A., Björkstrand, J., Larsson, E.-M., Furmark, T., Fredrikson, M., Disruption of reconsolidation erases a fear memory trace in the human amygdala (2012) Science, 337, pp. 1550-1552
  • Alberini, C.M., Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes? (2005) Trends Neurosci., 28, pp. 51-56
  • Alberini, C.M., Reconsolidation: the samsara of memory consolidation (2007) Debates Neurosci., 1, pp. 17-24
  • Alberini, C.M., (2013), http://books.google.es/books?hl=es%26lr=%26id=IR5Dxv9CNvYC%26oi=fnd%26pg=PA2003%26dq=alberini+reconsolidation%26ots=Wm8uBIdehh%26sig=rGDn1Y4VF6ZAfh9gTL-8KWEb3Zw, Memory Reconsolidation. Access Online via Elsevier; Anderson, M.C., Huddleston, E., True and False Recovered Memories: Toward a Reconciliation of the Debate (2012), 58, pp. 53-120. , In: Belli, R.F. (Ed.).Nebraska Symposium on Motivation, Towards a Cognitive and Neurobiological Model of Motivated Forgetting. Springer, New York; Anderson, M.C., Bjork, R.A., Bjork, E.L., Remembering can cause forgetting: retrieval dynamics in long-term memory (1994) J. Exp. Psychol. Learn. Memory Cogn., 20, pp. 1063-1087
  • Bouton, M.E., Context and behavioral processes in extinction (2004) Learn. Memory, 11, pp. 485-494
  • Bustos, S.G., Maldonado, H., Molina, V.A., Midazolam disrupts fear memory reconsolidation (2006) Neuroscience, 139, pp. 831-842
  • Cahill, L., Gorski, L., Le, K., Enhanced human memory consolidation with post-learning stress: interaction with the degree of arousal at encoding (2003) Learn. Memory, 10, pp. 270-274
  • Carbó Tano, M., Molina, V.A., Maldonado, H., Pedreira, M.E., Memory consolidation and reconsolidation in an invertebrate model: the role of the GABAergic system (2009) Neuroscience, 158, pp. 387-401
  • Coccoz, V., Maldonado, H., Delorenzi, A., The enhancement of reconsolidation with a naturalistic mild stressor improves the expression of a declarative memory in humans (2011) Neuroscience, 185, pp. 61-72
  • Corlett, P.R., Krystal, J.H., Taylor, J.R., Fletcher, P.C., Why do delusions persist? (2009) Front. Human Neurosci., 3. , http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713737/, (accessed 06.02.14)
  • Corlett, P.R., Cambridge, V., Gardner, J.M., Piggot, J.S., Turner, D.C., Everitt, J.C., Arana, F.S., Lee, J.L., Ketamine effects on memory reconsolidation favor a learning model of delusions (2013) PLoS ONE, 8, p. e65088
  • De Oliveira Alvares, L., Einarsson, E.Ö., Santana, F., Crestani, A.P., Haubrich, J., Cassini, L.F., Nader, K., Quillfeldt, J.A., Periodically reactivated context memory retains its precision and dependence on the hippocampus (2012) Hippocampus, 22, pp. 1092-1095
  • De Oliveira Alvares, L., Crestani, A.P., Cassini, L., Haubrich, J., Santana, F., Quillfeldt, J.A., Reactivation enables memory updating, precision-keeping and strengthening: exploring the possible biological roles of reconsolidation (2013) Neuroscience, , http://www.sciencedirect.com/science/article/pii/S0306452213003230
  • Debiec, J., Memory reconsolidation processes and posttraumatic stress disorder: promises and challenges of translational research (2012) Biol. Psychiatry, 71, pp. 284-285
  • Debiec, J., LeDoux, J.E., Disruption of reconsolidation but not consolidation of auditory fear conditioning by noradrenergic blockade in the amygdala (2004) Neuroscience, 129, pp. 267-272
  • Dudai, Y., (2002) Memory from A to Z: Keywords, Concepts, and Beyond, , http://www.lavoisier.fr/livre/notice.asp?id=OR6WSAA3OSLOWO, Oxford University Press, New York
  • Dudai, Y., The restless engram: consolidations never end (2012) Annu. Rev. Neurosci., 35, pp. 227-247
  • Dudai, Y., Eisenberg, M., Rites of passage of the engram: reconsolidation and the lingering consolidation hypothesis (2004) Neuron, 44, pp. 93-100
  • Eysenck, H.J., The learning theory model of neurosis-a new approach (1976) Behav. Res. Ther., 14, pp. 251-267
  • Finn, B., Roediger, H.L., Interfering effects of retrieval in learning new information (2013) J. Exp. Psychol. Learn. Memory Cogn., 39, p. 1665
  • Finnie, P.S.B., Nader, K., The role of metaplasticity mechanisms in regulating memory destabilization and reconsolidation (2012) Neurosci. Biobehav. Rev., 36, pp. 1667-1707
  • Forcato, C., Burgos, V.L., Argibay, P.F., Molina, V.A., Pedreira, M.E., Maldonado, H., Reconsolidation of declarative memory in humans (2007) Learn. Memory, 14, pp. 295-303
  • Forcato, C., Argibay, P.F., Pedreira, M.E., Maldonado, H., Human reconsolidation does not always occur when a memory is retrieved: the relevance of the reminder structure (2009) Neurobiol. Learn. Memory, 91, pp. 50-57
  • Forcato, C., Rodríguez, M.L.C., Pedreira, M.E., Maldonado, H., Reconsolidation in humans opens up declarative memory to the entrance of new information (2010) Neurobiol. Learn. Memory, 93, pp. 77-84
  • Forcato, C., Rodríguez, M.L.C., Pedreira, M.E., Repeated labilization-reconsolidation processes strengthen declarative memory in humans (2011) PLoS ONE, 6, p. e23305
  • Forcato, C., Fernandez, R.S., Pedreira, M.E., The role and dynamic of strengthening in the reconsolidation process in a human declarative memory: what decides the fate of recent and older memories? (2013) PLoS ONE, 8, p. e61688
  • Frenkel, L., Maldonado, H., Delorenzi, A., Memory strengthening by a real-life episode during reconsolidation: an outcome of water deprivation via brain angiotensin II (2005) Eur. J. Neurosci., 22, pp. 1757-1766
  • Gordon, W.C., Mechanisms of cue-induced retention enhancement (1981) Inform. Process. Animals: Memory Mech., pp. 319-339
  • Halligan, P.W., David, A.S., Cognitive neuropsychiatry: towards a scientific psychopathology (2001) Nat. Rev. Neurosci., 2, pp. 209-215
  • Hardt, O., Einarsson, E.Ö., Nader, K., A bridge over troubled water: reconsolidation as a link between cognitive and neuroscientific memory research traditions (2010) Annu. Rev. Psychol., 61, pp. 141-167
  • Hupbach, A., Gomez, R., Hardt, O., Nadel, L., Reconsolidation of episodic memories: a subtle reminder triggers integration of new information (2007) Learn. Memory, 14, pp. 47-53
  • Hupbach, A., Gomez, R., Nadel, L., Episodic memory reconsolidation: updating or source confusion? (2009) Memory, 17, pp. 502-510
  • Inda, M.C., Muravieva, E.V., Alberini, C.M., Memory retrieval and the passage of time: from reconsolidation and strengthening to extinction (2011) J. Neurosci., 31, pp. 1635-1643
  • Kandel, E.R., The molecular biology of memory storage: a dialog between genes and synapses (2001) Biosci. Rep., 21, pp. 565-611
  • Karpicke, J.D., Roediger, H.L., The critical importance of retrieval for learning (2008) Science, 319, pp. 966-968
  • Kindt, M., Soeter, M., Vervliet, B., Beyond extinction: erasing human fear responses and preventing the return of fear (2009) Nat. Neurosci., 12, pp. 256-258
  • Lee, J.L.C., Memory reconsolidation mediates the strengthening of memories by additional learning (2008) Nat. Neurosci., 11, pp. 1264-1266
  • Lee, J.L., Di Ciano, P., Thomas, K.L., Everitt, B.J., Disrupting reconsolidation of drug memories reduces cocaine-seeking behavior (2005) Neuron, 47, pp. 795-801
  • Lee, J.L.C., Milton, A.L., Everitt, B.J., Reconsolidation and extinction of conditioned fear: inhibition and potentiation (2006) J. Neurosci., 26, pp. 10051-10056
  • Lewis, D.J., Psychobiology of active and inactive memory (1979) Psychol. Bull., 86, p. 1054
  • Makkar, S.R., Zhang, S.Q., Cranney, J., Behavioral and neural analysis of GABA in the acquisition, consolidation, reconsolidation, and extinction of fear memory (2010) Neuropsychopharmacology, 35, pp. 1625-1652
  • McClelland, J.L., McNaughton, B.L., O'Reilly, R.C., Why there are complementary learning systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory (1995) Psychol. Rev., 102, pp. 419-457
  • McGaugh, J.L., Memory-a century of consolidation (2000) Science, 287, pp. 248-251
  • Muller, G.E., Pilzecker, A., Experimentelle beitrage zur lehre vom gedachtnis (1900) Z Psychol., 1, pp. 1-300
  • Müller, G.E., Pilzecker, A., (1970), Experimentelle beiträge zur lehre vom gedächtniss. Swets & Zeitlinger; Nadel, L., Moscovitch, M., Memory consolidation, retrograde amnesia and the hippocampal complex (1997) Curr. Opin. Neurobiol., 7, pp. 217-227
  • Nader, K., Hardt, O., A single standard for memory: the case for reconsolidation (2009) Nat. Rev. Neurosci., 10, pp. 224-234
  • Nader, K., Schafe, G.E., Le Doux, J.E., Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval (2000) Nature, 406, pp. 722-726
  • Pedreira, M.E., Maldonado, H., Protein synthesis subserves reconsolidation or extinction depending on reminder duration (2003) Neuron, 38, pp. 863-869
  • Pedreira, M.E., Pérez-Cuesta, L.M., Maldonado, H., Mismatch between what is expected and what actually occurs triggers memory reconsolidation or extinction (2004) Learn. Memory, 11, pp. 579-585
  • Potts, R., Shanks, D.R., Can testing immunize memories against interference? (2012) J. Exp. Psychol. Learn. Memory Cogn., 38, p. 1780
  • Przybyslawski, J., Sara, S.J., Reconsolidation of memory after its reactivation (1997) Behav. Brain Res., 84, pp. 241-246
  • Rasch, B., Büchel, C., Gais, S., Born, J., Odor cues during slow-wave sleep prompt declarative memory consolidation (2007) Science, 315, pp. 1426-1429
  • Rodríguez, M.L.C., Campos, J., Forcato, C., Leiguarda, R., Maldonado, H., Molina, V.A., Pedreira, M.E., Enhancing a declarative memory in humans: the effect of clonazepam on reconsolidation (2013) Neuropharmacology, 64, pp. 432-442
  • Saladin, M.E., Gray, K.M., McRae-Clark, A.L., Larowe, S.D., Yeatts, S.D., Baker, N.L., Hartwell, K.J., Brady, K.T., A double blind, placebo-controlled study of the effects of post-retrieval propranolol on reconsolidation of memory for craving and cue reactivity in cocaine dependent humans (2013) Psychopharmacology, 226, pp. 721-737
  • Sara, S.J., Retrieval and reconsolidation: toward a neurobiology of remembering (2000) Learn. Memory, 7, pp. 73-84
  • Schacter, D.L., Norman, K.A., Koutstaal, W., The cognitive neuroscience of constructive memory (2000), pp. 129-168. , False-memory Creation in Children and Adults: Theory, Research, and Implications; Schiller, D., Phelps, E.A., Does reconsolidation occur in humans? (2011) Front. Behav. Neurosci., 5. , http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099269
  • Schiller, D., Monfils, M.-H., Raio, C.M., Johnson, D.C., Ledoux, J.E., Phelps, E.A., Preventing the return of fear in humans using reconsolidation update mechanisms (2010) Nature, 463, pp. 49-53
  • Schwabe, L., Wolf, O.T., New episodic learning interferes with the reconsolidation of autobiographical memories (2009) PLoS ONE, 4, p. e7519
  • Smeets, T., Otgaar, H., Candel, I., Wolf, O.T., True or false? Memory is differentially affected by stress-induced cortisol elevations and sympathetic activity at consolidation and retrieval (2008) Psychoneuroendocrinology, 33, pp. 1378-1386
  • Squire, L.R., Alvarez, P., Retrograde amnesia and memory consolidation: a neurobiological perspective (1995) Curr. Opin. Neurobiol., 5, pp. 169-177
  • Strange, B.A., Kroes, M.C., Fan, J.E., Dolan, R.J., Emotion causes targeted forgetting of established memories (2010) Front. Behav. Neurosci., 4. , http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009474/
  • Suzuki, A., Josselyn, S.A., Frankland, P.W., Masushige, S., Silva, A.J., Kida, S., Memory reconsolidation and extinction have distinct temporal and biochemical signatures (2004) J. Neurosci., 24, pp. 4787-4795
  • Taylor, J.R., Olausson, P., Quinn, J.J., Torregrossa, M.M., Targeting extinction and reconsolidation mechanisms to combat the impact of drug cues on addiction (2009) Neuropharmacology, 56, pp. 186-195
  • Wichert, S., Wolf, O.T., Schwabe, L., Reactivation, interference, and reconsolidation: are recent and remote memories likewise susceptible? (2011) Behav. Neurosci., 125, pp. 699-704
  • Wichert, S., Wolf, O.T., Schwabe, L., Changing memories after reactivation: a one-time opportunity? (2012) Neurobiol. Learn. Memory
  • Wilson, B.A., Neuropsychological rehabilitation (2008) Annu. Rev. Clin. Psychol., 4, pp. 141-162
  • Wiltgen, B.J., Silva, A.J., Memory for context becomes less specific with time (2007) Learn. Memory, 14, pp. 313-317
  • Xue, Y.-X., Luo, Y.-X., Wu, P., Shi, H.-S., Xue, L.-F., Chen, C., Zhu, W.-L., Lu, L., A memory retrieval-extinction procedure to prevent drug craving and relapse (2012) Science, 336, pp. 241-245

Citas:

---------- APA ----------
Forcato, C., Fernandez, R.S. & Pedreira, M.E. (2014) . Strengthening a consolidated memory: The key role of the reconsolidation process. Journal of Physiology Paris, 108(4-6), 323-333.
http://dx.doi.org/10.1016/j.jphysparis.2014.09.001
---------- CHICAGO ----------
Forcato, C., Fernandez, R.S., Pedreira, M.E. "Strengthening a consolidated memory: The key role of the reconsolidation process" . Journal of Physiology Paris 108, no. 4-6 (2014) : 323-333.
http://dx.doi.org/10.1016/j.jphysparis.2014.09.001
---------- MLA ----------
Forcato, C., Fernandez, R.S., Pedreira, M.E. "Strengthening a consolidated memory: The key role of the reconsolidation process" . Journal of Physiology Paris, vol. 108, no. 4-6, 2014, pp. 323-333.
http://dx.doi.org/10.1016/j.jphysparis.2014.09.001
---------- VANCOUVER ----------
Forcato, C., Fernandez, R.S., Pedreira, M.E. Strengthening a consolidated memory: The key role of the reconsolidation process. J. Physiol. Paris. 2014;108(4-6):323-333.
http://dx.doi.org/10.1016/j.jphysparis.2014.09.001