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The reconsolidation hypothesis posits that the presentation of a specific cue, previously associated with a life event, makes the stored memory pass from a stable to a reactivated state. In this state, memory is again labile and susceptible to different agents, which may either damage or improve the original memory. Such susceptibility decreases over time and leads to a re-stabilization phase known as reconsolidation process. This process has been assigned two biological roles: memory updating, which suggests that destabilization of the original memory allows the integration of new information into the background of the original memory; and memory strengthening, which postulates that the labilization-reconsolidation process strengthens the original memory. The aim of this review is to analyze the strengthening as an improvement obtained only by triggering such process without any other treatment. In our lab, we have demonstrated that when triggering the labilization-reconsolidation process at least once the original memory becomes strengthened and increases its persistence. We have also shown that repeated labilization-reconsolidation processes strengthened the original memory by enlarging its precision, and said reinforced memories were more resistant to interference. Finally, we have shown that the strengthening function is not operative in older memories. We present and discuss both our findings and those of others, trying to reveal the central role of reconsolidation in the modification of stored information. © 2014 Elsevier Ltd.


Documento: Artículo
Título:Strengthening a consolidated memory: The key role of the reconsolidation process
Autor:Forcato, C.; Fernandez, R.S.; Pedreira, M.E.
Filiación:Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE - CONICET, Ciudad Universitaria, Pab. II, Buenos Aires, 1428, Argentina
Department of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany
Palabras clave:Declarative memory; Memory reconsolidation; Mismatch; Strengthening function; Translational applications; n methyl dextro aspartic acid receptor; accuracy; amnesia; cognition; cognitive rehabilitation; declarative memory; drug dependence; episodic memory; GABAergic system; human; learning; memory; memory consolidation; memory disorder; memory reconsolidation; memory strengthening; mental performance; neuromodulation; nonhuman; reinforcement; Review; stress; animal; long term memory; memory; physiology; recall; time; Animals; Humans; Memory; Mental Recall; Retention (Psychology); Time Factors
Página de inicio:323
Página de fin:333
Título revista:Journal of Physiology Paris
Título revista abreviado:J. Physiol. Paris


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---------- APA ----------
Forcato, C., Fernandez, R.S. & Pedreira, M.E. (2014) . Strengthening a consolidated memory: The key role of the reconsolidation process. Journal of Physiology Paris, 108(4-6), 323-333.
---------- CHICAGO ----------
Forcato, C., Fernandez, R.S., Pedreira, M.E. "Strengthening a consolidated memory: The key role of the reconsolidation process" . Journal of Physiology Paris 108, no. 4-6 (2014) : 323-333.
---------- MLA ----------
Forcato, C., Fernandez, R.S., Pedreira, M.E. "Strengthening a consolidated memory: The key role of the reconsolidation process" . Journal of Physiology Paris, vol. 108, no. 4-6, 2014, pp. 323-333.
---------- VANCOUVER ----------
Forcato, C., Fernandez, R.S., Pedreira, M.E. Strengthening a consolidated memory: The key role of the reconsolidation process. J. Physiol. Paris. 2014;108(4-6):323-333.