Artículo

Federman, N.; Zalcman, G.; de la Fuente, V.; Fustiñana, M.S.; Romano, A. "Epigenetic mechanisms and memory strength: A comparative study" (2014) Journal of Physiology Paris. 108(4-6):278-285
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Abstract:

Memory consolidation requires de novo mRNA and protein synthesis. Transcriptional activation is controlled by transcription factors, their cofactors and repressors. Cofactors and repressors regulate gene expression by interacting with basal transcription machinery, remodeling chromatin structure and/or chemically modifying histones. Acetylation is the most studied epigenetic mechanism of histones modification. s related to gene expression. This process is regulated by histone acetylases (HATs) and histone deacetylases (HDACs). More than 5. years ago, we began a line of research about the role of histone acetylation during memory consolidation. Here we review our work, presenting evidence about the critical role of this epigenetic mechanism during consolidation of context-signal memory in the crab Neohelice granulata, as well as during consolidation of novel object recognition memory in the mouse Mus musculus. Our evidence demonstrates that histone acetylation is a key mechanism in memory consolidation, functioning as a distinctive molecular feature of strong memories. Furthermore, we found that the strength of a memory can be characterized by its persistence or its resistance to extinction. Besides, we found that the role of this epigenetic mechanism regulating gene expression only in the formation of strongest memories is evolutionarily conserved. © 2014 Elsevier Ltd.

Registro:

Documento: Artículo
Título:Epigenetic mechanisms and memory strength: A comparative study
Autor:Federman, N.; Zalcman, G.; de la Fuente, V.; Fustiñana, M.S.; Romano, A.
Filiación:Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires. IFIByNE, CONICET, Ciudad Universitaria, Pab. II, 2do piso, Buenos Aires, 1428EHA, Argentina
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, 4058, Switzerland
Palabras clave:Chromatin modifications; Gene expression; Histone acetylation; Long-term memory; Memory persistence; butyric acid; calcium calmodulin dependent protein kinase II; cyclic AMP dependent protein kinase; early growth response factor 1; histone; histone acetyltransferase; histone deacetylase; histone H3; immunoglobulin enhancer binding protein; messenger RNA; mitogen activated protein kinase; transcription factor; trichostatin A; histone; immunoglobulin enhancer binding protein; chromatin assembly and disassembly; chromatin structure; comparative study; crab; epigenetics; gene expression; gene expression regulation; genetic conservation; histone acetylation; histone modification; long term memory; memory consolidation; mouse; nonhuman; protein interaction; protein synthesis; recognition; reinforcement; Review; RNA synthesis; signal transduction; transcription initiation; acetylation; animal; genetic epigenesis; human; memory; metabolism; physiology; Acetylation; Animals; Epigenesis, Genetic; Epigenomics; Histones; Humans; Memory; NF-kappa B
Año:2014
Volumen:108
Número:4-6
Página de inicio:278
Página de fin:285
DOI: http://dx.doi.org/10.1016/j.jphysparis.2014.06.003
Título revista:Journal of Physiology Paris
Título revista abreviado:J. Physiol. Paris
ISSN:09284257
CODEN:JHYSE
CAS:butyric acid, 107-92-6, 156-54-7, 461-55-2; calcium calmodulin dependent protein kinase II, 141467-21-2; cyclic AMP dependent protein kinase; histone, 9062-68-4; histone acetyltransferase, 9054-51-7; histone deacetylase, 9076-57-7; mitogen activated protein kinase, 142243-02-5; trichostatin A, 58880-19-6; Histones; NF-kappa B
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n4-6_p278_Federman

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Citas:

---------- APA ----------
Federman, N., Zalcman, G., de la Fuente, V., Fustiñana, M.S. & Romano, A. (2014) . Epigenetic mechanisms and memory strength: A comparative study. Journal of Physiology Paris, 108(4-6), 278-285.
http://dx.doi.org/10.1016/j.jphysparis.2014.06.003
---------- CHICAGO ----------
Federman, N., Zalcman, G., de la Fuente, V., Fustiñana, M.S., Romano, A. "Epigenetic mechanisms and memory strength: A comparative study" . Journal of Physiology Paris 108, no. 4-6 (2014) : 278-285.
http://dx.doi.org/10.1016/j.jphysparis.2014.06.003
---------- MLA ----------
Federman, N., Zalcman, G., de la Fuente, V., Fustiñana, M.S., Romano, A. "Epigenetic mechanisms and memory strength: A comparative study" . Journal of Physiology Paris, vol. 108, no. 4-6, 2014, pp. 278-285.
http://dx.doi.org/10.1016/j.jphysparis.2014.06.003
---------- VANCOUVER ----------
Federman, N., Zalcman, G., de la Fuente, V., Fustiñana, M.S., Romano, A. Epigenetic mechanisms and memory strength: A comparative study. J. Physiol. Paris. 2014;108(4-6):278-285.
http://dx.doi.org/10.1016/j.jphysparis.2014.06.003