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Abstract:

Several transcription factors are present at the synapse, and among these are the Rel-NF-kappa B pathway components. NF-kappa B is a constitutive transcription factor, with a strong presence in the brain of which a considerable part is located in the neuropiles. This localization of the transcription factor, plus evidence pointing to different functions, is what gave place to two general hypotheses for synaptic NF-kappa B: (a) The transcription factor plays a role in the synapse to nucleus communication, and it is retrogradely transported from polarized localizations to regulate gene expression; (b) The transcription factor modulates the synaptic function locally. Evidence indicates that both mechanisms can operate simultaneously; here we will present different possibilities of these hypotheses that are supported by an increasing amount of data. We pay special attention to the local role of the transcription factor at the synapse, and based in the described evidence from different animal models, we propose several processes in which the transcription factor may change the synaptic strength. © 2014 Elsevier Ltd.

Registro:

Documento: Artículo
Título:Synaptic NF-kappa B pathway in neuronal plasticity and memory
Autor:Salles, A.; Romano, A.; Freudenthal, R.
Filiación:Laboratorio de Neurobiología de la Memoria, FBMC, FCEyN, UBA, IFIBYNE, CONICET, Ciudad Universitaria, 2 piso, pabellón II, Intendente Güiraldez 2160, Ciudad Autónoma de Buenos Aires, CP 1428, Argentina
Palabras clave:Learning-induced plasticity; Post-translational modifications; Receptor clustering; Retrograde transport; Synaptic NF-kappa B; calcium calmodulin dependent protein kinase II; cholinergic receptor; dynactin; dynein adenosine triphosphatase; I kappa B; I kappa B kinase; immunoglobulin enhancer binding protein; messenger RNA; postsynaptic density protein 95; transcription factor Rel; transcription factor RelA; immunoglobulin enhancer binding protein; cell communication; cell nucleus; experimental model; gene expression regulation; human; long term memory; long term potentiation; memory consolidation; mouse; nerve cell plasticity; neuromuscular synapse; neuropil; nonhuman; postsynaptic potential; protein function; protein localization; protein phosphorylation; protein transport; rat; receptor density; reinforcement; Review; synapse; synaptogenesis; animal; memory; metabolism; nerve cell plasticity; physiology; Animals; Memory; Neuronal Plasticity; NF-kappa B; Synapses
Año:2014
Volumen:108
Número:4-6
Página de inicio:256
Página de fin:262
DOI: http://dx.doi.org/10.1016/j.jphysparis.2014.05.002
Título revista:Journal of Physiology Paris
Título revista abreviado:J. Physiol. Paris
ISSN:09284257
CODEN:JHYSE
CAS:calcium calmodulin dependent protein kinase II, 141467-21-2; dynein adenosine triphosphatase; I kappa B kinase, 209902-66-9; NF-kappa B
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n4-6_p256_Salles

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Citas:

---------- APA ----------
Salles, A., Romano, A. & Freudenthal, R. (2014) . Synaptic NF-kappa B pathway in neuronal plasticity and memory. Journal of Physiology Paris, 108(4-6), 256-262.
http://dx.doi.org/10.1016/j.jphysparis.2014.05.002
---------- CHICAGO ----------
Salles, A., Romano, A., Freudenthal, R. "Synaptic NF-kappa B pathway in neuronal plasticity and memory" . Journal of Physiology Paris 108, no. 4-6 (2014) : 256-262.
http://dx.doi.org/10.1016/j.jphysparis.2014.05.002
---------- MLA ----------
Salles, A., Romano, A., Freudenthal, R. "Synaptic NF-kappa B pathway in neuronal plasticity and memory" . Journal of Physiology Paris, vol. 108, no. 4-6, 2014, pp. 256-262.
http://dx.doi.org/10.1016/j.jphysparis.2014.05.002
---------- VANCOUVER ----------
Salles, A., Romano, A., Freudenthal, R. Synaptic NF-kappa B pathway in neuronal plasticity and memory. J. Physiol. Paris. 2014;108(4-6):256-262.
http://dx.doi.org/10.1016/j.jphysparis.2014.05.002