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Abstract:

The Mauthner-cell (M-cell) system of teleost fish has a long history as an experimental model for addressing a wide range of neurobiological questions. Principles derived from studies on this system have contributed significantly to our understanding at multiple levels, from mechanisms of synaptic transmission and synaptic plasticity to the concepts of a decision neuron that initiates key aspects of the startle behavior. Here we will review recent work that focuses on the neurophysiological and neuropharmacological basis for modifications in the M-cell circuit. After summarizing the main excitatory and inhibitory inputs to the M-cell, we review experiments showing startle response modulation by temperature, social status, and sensory filtering. Although very different in nature, actions of these three sources of modulation converge in the M-cell network. Mechanisms of modulation include altering the excitability of the M-cell itself as well as changes in excitatory and inhibitor drive, highlighting the role of balanced excitation and inhibition for escape decisions. One of the most extensively studied forms of startle plasticity in vertebrates is prepulse inhibition (PPI), a sensorimotor gating phenomenon, which is impaired in several information processing disorders. Finally, we review recent work in the M-cell system which focuses on the cellular mechanisms of PPI and its modulation by serotonin and dopamine. © 2014 Elsevier Ltd.

Registro:

Documento: Artículo
Título:The Mauthner-cell circuit of fish as a model system for startle plasticity
Autor:Medan, V.; Preuss, T.
Filiación:Dept. de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Guiraldes 2160, Buenos Aires, 1428, Argentina
Instituto de Fisiología, Biología Molecular y Neurociencias, CONICET, Argentina
Psychology Dept. Hunter College, City University of New York, 695 Park Ave., New York, NY 10065, United States
Palabras clave:Dopamine; Mauthner cell; Prepulse inhibition; Serotonin; Social status; Startle response; Temperature; dopamine; serotonin; auditory lateralization; auditory stimulation; dopaminergic system; environmental factor; escape behavior; excitability; Mauthner cell; nerve cell network; nerve cell plasticity; neuromodulation; nonhuman; postsynaptic potential; prepulse inhibition; presynaptic potential; Review; sensorimotor function; sensory gating; social status; startle reflex; synaptic transmission; teleost; temperature; visual stimulation; animal; animal behavior; fish; nerve cell inhibition; nerve cell plasticity; physiology; startle reflex; Acoustic Stimulation; Animals; Behavior, Animal; Fishes; Nerve Net; Neural Inhibition; Neuronal Plasticity; Reflex, Startle; Sensory Gating
Año:2014
Volumen:108
Número:2-3
Página de inicio:129
Página de fin:140
DOI: http://dx.doi.org/10.1016/j.jphysparis.2014.07.006
Título revista:Journal of Physiology Paris
Título revista abreviado:J. Physiol. Paris
ISSN:09284257
CODEN:JHYSE
CAS:dopamine, 51-61-6, 62-31-7; serotonin, 50-67-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n2-3_p129_Medan

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Citas:

---------- APA ----------
Medan, V. & Preuss, T. (2014) . The Mauthner-cell circuit of fish as a model system for startle plasticity. Journal of Physiology Paris, 108(2-3), 129-140.
http://dx.doi.org/10.1016/j.jphysparis.2014.07.006
---------- CHICAGO ----------
Medan, V., Preuss, T. "The Mauthner-cell circuit of fish as a model system for startle plasticity" . Journal of Physiology Paris 108, no. 2-3 (2014) : 129-140.
http://dx.doi.org/10.1016/j.jphysparis.2014.07.006
---------- MLA ----------
Medan, V., Preuss, T. "The Mauthner-cell circuit of fish as a model system for startle plasticity" . Journal of Physiology Paris, vol. 108, no. 2-3, 2014, pp. 129-140.
http://dx.doi.org/10.1016/j.jphysparis.2014.07.006
---------- VANCOUVER ----------
Medan, V., Preuss, T. The Mauthner-cell circuit of fish as a model system for startle plasticity. J. Physiol. Paris. 2014;108(2-3):129-140.
http://dx.doi.org/10.1016/j.jphysparis.2014.07.006