Artículo

Paganelli, A.R.; Ocaña, O.; Prat, M.I.; Franco, P.G.; López, S.L.; Morelli, L.; Adamo, A.M.; Riccomagno, M.M.; Matsubara, E.; Shoji, M.; Affranchino, J.L.; Castaño, E.M.; Carrasco, A.E. "The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis" (2001) Mechanisms of Development. 107(1-2):119-131
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Abstract:

We analyzed the influence of presenilins on the genetic cascades that control neuronal differentiation in Xenopus embryos. Resembling sonic hedgehog (shh) overexpression, presenilin mRNA injection reduced the number of N-tubulin+ primary neurons and modulated Gli3 and Zic2 according to their roles in activating and repressing primary neurogenesis, respectively. Presenilin increased shh expression within its normal domain, mainly in the floor plate, whereas an antisense X-presenilin-α morpholino oligonucleotide reduced shh expression. Both shh and presenilin promoted cell proliferation and apoptosis, but the effects of shh were widely distributed, while those resulting from presenilin injection coincided with the range of shh signaling. We suggest that presenilin may modulate primary neurogenesis, proliferation, and apoptosis in the neural plate, through the enhancement of shh signaling. Copyright © 2001 Elsevier Science Ireland Ltd.

Registro:

Documento: Artículo
Título:The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis
Autor:Paganelli, A.R.; Ocaña, O.; Prat, M.I.; Franco, P.G.; López, S.L.; Morelli, L.; Adamo, A.M.; Riccomagno, M.M.; Matsubara, E.; Shoji, M.; Affranchino, J.L.; Castaño, E.M.; Carrasco, A.E.
Filiación:Laboratorio de Embriología Molecular, Inst. de Biol. Cel. y Neurociencias, Universidad de Buenos Aires, Paraguay 2155, 3piso, Buenos Aires, Argentina
Instituto de Quimica y Fisicoquimica Biologicas, Departamento de Quimica Biologica, Universidad de Buenos Aires, Junín 956 (1113), Buenos Aires, Argentina
Department of Neurology, Gunma University School of Medicine, Gunma, Japan
Centro de Virología Animal (CEVAN-CONICET), Buenos Aires, Argentina
Palabras clave:Apoptosis; Morpholino oligonucleotide; Presenilin; Primary neurogenesis; Proliferation; Sonic hedgehog; Xenopus laevis; antisense oligonucleotide; messenger RNA; presenilin 1; sonic hedgehog protein; Alzheimer disease; apoptosis; article; controlled study; embryo; gene expression regulation; immunohistochemistry; nervous system development; nonhuman; priority journal; reverse transcription polymerase chain reaction; Xenopus; Xenopus
Año:2001
Volumen:107
Número:1-2
Página de inicio:119
Página de fin:131
DOI: http://dx.doi.org/10.1016/S0925-4773(01)00458-0
Título revista:Mechanisms of Development
Título revista abreviado:Mech. Dev.
ISSN:09254773
CODEN:MEDVE
CAS:presenilin 1, 186986-30-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09254773_v107_n1-2_p119_Paganelli

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Citas:

---------- APA ----------
Paganelli, A.R., Ocaña, O., Prat, M.I., Franco, P.G., López, S.L., Morelli, L., Adamo, A.M.,..., Carrasco, A.E. (2001) . The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis. Mechanisms of Development, 107(1-2), 119-131.
http://dx.doi.org/10.1016/S0925-4773(01)00458-0
---------- CHICAGO ----------
Paganelli, A.R., Ocaña, O., Prat, M.I., Franco, P.G., López, S.L., Morelli, L., et al. "The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis" . Mechanisms of Development 107, no. 1-2 (2001) : 119-131.
http://dx.doi.org/10.1016/S0925-4773(01)00458-0
---------- MLA ----------
Paganelli, A.R., Ocaña, O., Prat, M.I., Franco, P.G., López, S.L., Morelli, L., et al. "The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis" . Mechanisms of Development, vol. 107, no. 1-2, 2001, pp. 119-131.
http://dx.doi.org/10.1016/S0925-4773(01)00458-0
---------- VANCOUVER ----------
Paganelli, A.R., Ocaña, O., Prat, M.I., Franco, P.G., López, S.L., Morelli, L., et al. The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis. Mech. Dev. 2001;107(1-2):119-131.
http://dx.doi.org/10.1016/S0925-4773(01)00458-0