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Abstract:

The antiviral mode of action of the synthetic brassinosteroid (22S,23S)-3β-bromo-5α,22,23-trihydroxystigmastan-6-one (6b) against replication of vesicular stomatitis virus (VSV) in Vero cells was investigated. Time-related experiments showed that 6b mainly affects a late event of the virus growth cycle. Virus adsorption, internalisation and early RNA synthesis are not the target of the inhibitory action. Results obtained indicate that the antiviral compound adversely affects virus protein synthesis and viral mature particle formation. © 2006 Elsevier B.V. and the International Society of Chemotherapy.

Registro:

Documento: Artículo
Título:Antiviral effect of a synthetic brassinosteroid on the replication of vesicular stomatitis virus in Vero cells
Autor:Romanutti, C.; Castilla, V.; Coto, C.E.; Wachsman, M.B.
Filiación:Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina
Palabras clave:(22S,23S)-3β-bromo-5α,22,23-trihydroxystigmastan-6-one; Antiviral activity; Brassinosteroids; Vesicular stomatitis virus; 3beta bromo 5alpha,22,23 trihydroxystigmastan 6 one; brassinosteroid; steroid hormone; unclassified drug; animal cell; antiviral activity; article; controlled study; dose time effect relation; internalization; nonhuman; priority journal; protein synthesis; RNA synthesis; stomatitis; Vero cell; Vesicular stomatitis virus; virogenesis; virus adsorption; virus inhibition; virus replication; Animals; Antiviral Agents; Base Sequence; Cercopithecus aethiops; DNA, Viral; Molecular Structure; RNA, Viral; Steroids; Vero Cells; Vesicular stomatitis-Indiana virus; Virus Replication
Año:2007
Volumen:29
Número:3
Página de inicio:311
Página de fin:316
DOI: http://dx.doi.org/10.1016/j.ijantimicag.2006.11.005
Título revista:International Journal of Antimicrobial Agents
Título revista abreviado:Int. J. Antimicrob. Agents
ISSN:09248579
CODEN:IAAGE
CAS:Antiviral Agents; DNA, Viral; RNA, Viral; Steroids
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09248579_v29_n3_p311_Romanutti

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Citas:

---------- APA ----------
Romanutti, C., Castilla, V., Coto, C.E. & Wachsman, M.B. (2007) . Antiviral effect of a synthetic brassinosteroid on the replication of vesicular stomatitis virus in Vero cells. International Journal of Antimicrobial Agents, 29(3), 311-316.
http://dx.doi.org/10.1016/j.ijantimicag.2006.11.005
---------- CHICAGO ----------
Romanutti, C., Castilla, V., Coto, C.E., Wachsman, M.B. "Antiviral effect of a synthetic brassinosteroid on the replication of vesicular stomatitis virus in Vero cells" . International Journal of Antimicrobial Agents 29, no. 3 (2007) : 311-316.
http://dx.doi.org/10.1016/j.ijantimicag.2006.11.005
---------- MLA ----------
Romanutti, C., Castilla, V., Coto, C.E., Wachsman, M.B. "Antiviral effect of a synthetic brassinosteroid on the replication of vesicular stomatitis virus in Vero cells" . International Journal of Antimicrobial Agents, vol. 29, no. 3, 2007, pp. 311-316.
http://dx.doi.org/10.1016/j.ijantimicag.2006.11.005
---------- VANCOUVER ----------
Romanutti, C., Castilla, V., Coto, C.E., Wachsman, M.B. Antiviral effect of a synthetic brassinosteroid on the replication of vesicular stomatitis virus in Vero cells. Int. J. Antimicrob. Agents. 2007;29(3):311-316.
http://dx.doi.org/10.1016/j.ijantimicag.2006.11.005