Artículo
Wachsman, M.B.; Castilla, V.; Talarico, L.B.; Ramirez, J.A.; Galagovsky, L.R.; Coto, C.E. "Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro" (2004) International Journal of Antimicrobial Agents. 23(5):524-526
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Abstract:
The replication of herpes simplex virus (HSV) type 1 in Vero cells is inhibited in the presence of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one (6b), a synthetic brassinosteroid derivative. Attempts to disclose the mode of action of 6b indicate that a late step of virus multiplication is affected. In the presence of 6b, HSV late protein synthesis was severely diminished and this inhibitory effect of 6b on HSV antigen expression was confirmed by immunofluorescence assays. © 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Registro:
| Documento: | Artículo |
| Título: | Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro |
| Autor: | Wachsman, M.B.; Castilla, V.; Talarico, L.B.; Ramirez, J.A.; Galagovsky, L.R.; Coto, C.E. |
| Filiación: | Laboratorio de Virología, Depto. de Quím. Biol., Pabellón 2, 1428 Buenos Aires, Argentina Depto. de Quím. Orgán., Fac. de Ciencias Exactas Y Naturales, Pabellón 2, 1428 Buenos Aires, Argentina |
| Palabras clave: | (22S,23S)-3β- Bromo-5α,22,23-trihydroxystigmastan-6-one; Antiviral; Brassinosteroid derivatives; Herpes simplex; 3beta bromo 5alpha,22,23 trihydroxystigmastan 6 one; antivirus agent; brassinosteroid; unclassified drug; animal cell; antigen expression; article; controlled study; drug mechanism; Herpes simplex virus 1; immunofluorescence test; in vitro study; nonhuman; priority journal; protein synthesis; Vero cell; virus replication; Animals; Antigens, Viral; Antiviral Agents; Cercopithecus aethiops; Cholestanones; Fluorescent Antibody Technique, Indirect; Herpesvirus 1, Human; Transcription, Genetic; Vero Cells; Viral Proteins; Virus Replication |
| Año: | 2004 |
| Volumen: | 23 |
| Número: | 5 |
| Página de inicio: | 524 |
| Página de fin: | 526 |
| DOI: | http://dx.doi.org/10.1016/j.ijantimicag.2003.10.002 |
| Título revista: | International Journal of Antimicrobial Agents |
| Título revista abreviado: | Int. J. Antimicrob. Agents |
| ISSN: | 09248579 |
| CODEN: | IAAGE |
| CAS: | (22S,23S)-3beta-bromo-5alpha,22,23-trihydroxystigmastan-6-one; Antigens, Viral; Antiviral Agents; Cholestanones; Viral Proteins |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09248579_v23_n5_p524_Wachsman |
Referencias:
- Wachsman, M.B., López, E.M.F., Ramírez, J.A., Galagovsky, L.R., Coto, C.E., Antiviral effect of brassinosteroids against herpes virus and arenaviruses (2000) Antivir. Chem. Chemother., 11, pp. 71-77
- Wachsman, M.B., Ramírez, J.A., Galagovsky, L.R., Coto, C.E., Antiviral activity of brassinosteroids derivatives against measles virus in cell cultures (2002) Antivir. Chem. Chemother., 13, pp. 61-66
- Talarico, L.B., Ramirez, J.A., Galagovsky, L.R., Wachsman, M.B., Structure-activity relationship studies in a set of new brassinosteroid derivatives assayed against herpes simplex virus type 1 and 2 in cell cultures (2002) Med. Chem. Res., 11, pp. 434-444
- Schaller, H., The role of sterols in plant growth and development (2003) Prog. Lipid Res., 42, pp. 163-175
- Teme Centurión, O.M., Galagovsky, L.R., Alternative synthesis of 24(S)-homoethylcastasterone from stigmasterol (1998) Anal. Asoc. Quím. Arg., 86, pp. 104-109
- Ramírez, J., Gros, E., Galagovsky, L., Synthesis and bioactivity evaluation of brassinosteroid analogs (2000) Steroids, 65, pp. 329-337
- Koehn, F.F., Gunasekera, M., Cross, S.S., New antiviral sterol disulfate ortho esters from the marine sponge Petrosia weinbergi (1991) J. Org. Chem., 56, pp. 1322-1325
- Comin, M.J., Maier, M.S., Roccatagliata, A.J., Pujol, C.A., Damonte, E.B., Evaluation of the antiviral activity of natural sulfated polyhydroxy-steroids and their synthetic derivatives and analogues (1999) Steroids, 64, pp. 335-340
Citas:
---------- APA ----------
Wachsman, M.B., Castilla, V., Talarico, L.B., Ramirez, J.A., Galagovsky, L.R. & Coto, C.E. (2004) . Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro. International Journal of Antimicrobial Agents, 23(5), 524-526.http://dx.doi.org/10.1016/j.ijantimicag.2003.10.002
---------- CHICAGO ----------
Wachsman, M.B., Castilla, V., Talarico, L.B., Ramirez, J.A., Galagovsky, L.R., Coto, C.E. "Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro" . International Journal of Antimicrobial Agents 23, no. 5 (2004) : 524-526.http://dx.doi.org/10.1016/j.ijantimicag.2003.10.002
---------- MLA ----------
Wachsman, M.B., Castilla, V., Talarico, L.B., Ramirez, J.A., Galagovsky, L.R., Coto, C.E. "Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro" . International Journal of Antimicrobial Agents, vol. 23, no. 5, 2004, pp. 524-526.http://dx.doi.org/10.1016/j.ijantimicag.2003.10.002
---------- VANCOUVER ----------
Wachsman, M.B., Castilla, V., Talarico, L.B., Ramirez, J.A., Galagovsky, L.R., Coto, C.E. Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro. Int. J. Antimicrob. Agents. 2004;23(5):524-526.http://dx.doi.org/10.1016/j.ijantimicag.2003.10.002
