Abstract:
The in vitro antiviral activity of antimicrobial cationic peptides: cecropin A, melittin, magainin I and II and indolicidin against the arenavirus Junin virus (JV), and herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) was evaluated. Cecropin A effectively inhibited JV multiplication and failed to affect HSV replication whereas melittin impeded the multiplication of JV and HSV, but was highly toxic for the host cell. Magainins I and II exhibited inhibitory action toward HSV-1 and HSV-2 but were inactive against JV. Only indolicidin showed a direct inactivation effect on cell-free virus stocks. Besides its inhibitory effect on JV replication cecropin A also was active against the arenaviruses Tacaribe and Pichinde, mainly affecting late events of arenavirus multiplication cycle by preventing viral morphogenesis and egress from infected cells. © 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Registro:
Documento: |
Artículo
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Título: | Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus |
Autor: | Albiol Matanic, V.C.; Castilla, V. |
Filiación: | Laboratorio de Virología, Depto. de Quím. Biol., Pabellón II, C1428BGA Buenos Aires, Argentina
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Palabras clave: | Antimicrobial peptides; Antiviral activity; Arenavirus; Herpesvirus; antivirus agent; cecropin A; indolicidin; magainin 1; magainin 2; melittin; protein; animal cell; antiviral activity; Arenavirus; article; controlled study; Herpes simplex virus 1; Herpes simplex virus 2; host cell; in vitro study; Junin virus; nonhuman; Pichinde arenavirus; priority journal; virus inactivation; virus morphogenesis; virus replication; Animals; Anti-Infective Agents; Antimicrobial Cationic Peptides; Cell Line; Cercopithecus aethiops; Cricetinae; Herpesvirus 1, Human; Herpesvirus 2, Human; Junin virus; Microbial Sensitivity Tests; Vero Cells; Virus Replication |
Año: | 2004
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Volumen: | 23
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Número: | 4
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Página de inicio: | 382
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Página de fin: | 389
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DOI: |
http://dx.doi.org/10.1016/j.ijantimicag.2003.07.022 |
Título revista: | International Journal of Antimicrobial Agents
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Título revista abreviado: | Int. J. Antimicrob. Agents
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ISSN: | 09248579
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CODEN: | IAAGE
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CAS: | cecropin A, 80451-04-3; indolicidin, 140896-21-5; magainin 1, 108433-99-4; magainin 2, 108433-95-0; melittin, 20449-79-0, 37231-28-0, 65742-02-1; protein, 67254-75-5; Anti-Infective Agents; Antimicrobial Cationic Peptides
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09248579_v23_n4_p382_AlbiolMatanic |
Referencias:
- Nicolas, P., Mor, A., Peptides as weapons against microorganisms in the chemical defense system of vertebrates (1995) Annu. Rev. Microbiol., 49, pp. 277-304
- Andreu, D., Rivas, L., Animal antimicrobial peptides: An overview (1998) Biopolymers, 47, pp. 415-433
- Hancock, R.E.W., Chapple, D.S., Peptide antibiotics (1999) Antimicrob. Agents Chemother., 43, pp. 1317-1323
- Hancock, R.E.W., Diamond, G., The role of cationic antimicrobial peptides in innate host defences (2000) Trends Microbiol., 8, pp. 402-410
- Daher, K.A., Selsted, M.E., Lehrer, R.I., Direct inactivation of viruses by human granulocyte defensins (1986) J. Virol., 60, pp. 1068-1074
- Wachinger, M., Kleinschmidt, A., Winder, D., Von Pechmann, N., Ludvigsen, A., Neumann, M., Antimicrobial peptides melittin and cecropin inhibit replication of human immunodeficiency virus 1 by suppressing viral gene expression (1998) J. Gen. Virol., 309, pp. 235-241
- Wachinger, M., Saermark, T., Erfle, V., Influence of amphipathic peptides on the HIV-1 production in persistently infected T-lymphoma cells (1992) FEBS Lett., 309, pp. 235-241
- Baghian, A., Kousoulas, K.G., Role of the Na+, K+ pump in herpes simplex type 1-induced cell fusion: Melittin causes specific reversion of syncytial mutants with the syn 1 mutation to syn+ (wild type) phenotype (1993) Virology, 196, pp. 548-556
- Nissen Meyer, J., Nes, I.F., Ribosomally synthesized antimicrobial peptides: Their function, structure, biogenesis and mechanism of action (1997) Arch. Microbiol., 167, pp. 67-77
- Egal, M., Conrad, M., MacDonald, D.L., Maloy, W.L., Motley, M., Attardo Genco, C., Antiviral effects of synthetic membrane-active peptides on herpes simplex virus, type 1 (1999) Int. J. Antimicrob. Agents, 13, pp. 57-60
- Robinson, W.E.Jr., McDougall, B., Tran, D., Selsted, M.E., Anti-HIV-1 activity of indolicidin, an antimicrobial peptide from neutrophils (1998) J. Leukoc. Biol., 63, pp. 94-100
- Damonte, E.B., Coto, C.E., Treatment of arenavirus infections: From basic studies to the challenge of antiviral therapy (2002) Adv. Virus Res., 58, pp. 125-155
- McCormick, J.B., King, I.J., Webb, P.A., Scribner, C.L., Craven, R.B., Johnson, K.M., Lassa fever. Effective therapy with ribavirin (1986) N. Engl. J. Med., 314, pp. 20-26
- McKee, K.T., Huggins, J.W., Trahan, C.J., Mahlandi, B.G., Ribavirin prophylaxis and therapy for experimental Argentine hemorrhagic fever (1988) Antimicrob. Agents Chemother., 32, pp. 1304-1309
- Enria, D.A., Maiztegui, J.I., Antiviral treatment of Argentine hemorrhagic fever (1994) Antiviral Res., 23, pp. 23-31
- Candurra, N.A., Damonte, E.B., Coto, C.E., Antigenic relationships among attenuated and pathogenic strains of Junin virus (1989) J. Med. Virol., 27, pp. 145-150
- Wachsman, M.B., López, E.M.F., Ramirez, J.A., Galagovsky, L.R., Coto, C.E., Antiviral effect of brassinosteroids against herpes virus and arenaviruses (2000) Antiviral Chem. Chemother., 11, pp. 71-77
- Sánchez, A., Pifat, D.Y., Kenyon, R.H., Peters, C.J., Mc Cornmick, J.B., Kiley, M.P., Junin virus monoclonal antibodies: Characterization and cross-reactivity with other arenaviruses (1989) J. Gen. Virol., 70, pp. 1125-1132
- Castilla, V., Palermo, L.M., Coto, C.E., Involvement of vacuolar proton ATPase in Junin virus multiplication (2001) Arch. Virol., 146, pp. 251-263
- Buchmeier, M.J., Arenaviruses: Protein structure and function (2002) Curr. Top. Microbiol. Immunol., 262, pp. 159-173
- Candurra, N.A., Damonte, E.B., Effect of inhibitors of the intracellular exocytic pathway on glycoprotein processing and maduration of Junin virus (1997) Arch. Virol., 142, pp. 2179-2193
- Mersich, S.E., Castilla, V., Damonte, E.B., Lectin affinity of Junin virus glycoproteins (1988) Ann. Inst. Pasteur Virol., 139, pp. 277-284
- Aboudy, Y., Mendelson, E., Shalit, I., Bessalle, R., Fridkin, M., Activity of two synthetic amphiphilic peptides and magainin-2 against herpes simplex virus types 1 and 2 (1994) Int. J. Pept. Protein Res., 43, pp. 573-582
- Compans, R.W., Arenavirus ultrastructure and morphogenesis (1993) The Arenaviridae, , Salvato MS, editor. New York: Plenum Press;
- Mettenleiter, T.C., Herpesvirus assembly and egress (2002) J. Virol., 76, pp. 1537-1547
Citas:
---------- APA ----------
Albiol Matanic, V.C. & Castilla, V.
(2004)
. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. International Journal of Antimicrobial Agents, 23(4), 382-389.
http://dx.doi.org/10.1016/j.ijantimicag.2003.07.022---------- CHICAGO ----------
Albiol Matanic, V.C., Castilla, V.
"Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus"
. International Journal of Antimicrobial Agents 23, no. 4
(2004) : 382-389.
http://dx.doi.org/10.1016/j.ijantimicag.2003.07.022---------- MLA ----------
Albiol Matanic, V.C., Castilla, V.
"Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus"
. International Journal of Antimicrobial Agents, vol. 23, no. 4, 2004, pp. 382-389.
http://dx.doi.org/10.1016/j.ijantimicag.2003.07.022---------- VANCOUVER ----------
Albiol Matanic, V.C., Castilla, V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int. J. Antimicrob. Agents. 2004;23(4):382-389.
http://dx.doi.org/10.1016/j.ijantimicag.2003.07.022