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Abstract:

The in vitro antiviral activity of antimicrobial cationic peptides: cecropin A, melittin, magainin I and II and indolicidin against the arenavirus Junin virus (JV), and herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) was evaluated. Cecropin A effectively inhibited JV multiplication and failed to affect HSV replication whereas melittin impeded the multiplication of JV and HSV, but was highly toxic for the host cell. Magainins I and II exhibited inhibitory action toward HSV-1 and HSV-2 but were inactive against JV. Only indolicidin showed a direct inactivation effect on cell-free virus stocks. Besides its inhibitory effect on JV replication cecropin A also was active against the arenaviruses Tacaribe and Pichinde, mainly affecting late events of arenavirus multiplication cycle by preventing viral morphogenesis and egress from infected cells. © 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

Registro:

Documento: Artículo
Título:Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus
Autor:Albiol Matanic, V.C.; Castilla, V.
Filiación:Laboratorio de Virología, Depto. de Quím. Biol., Pabellón II, C1428BGA Buenos Aires, Argentina
Palabras clave:Antimicrobial peptides; Antiviral activity; Arenavirus; Herpesvirus; antivirus agent; cecropin A; indolicidin; magainin 1; magainin 2; melittin; protein; animal cell; antiviral activity; Arenavirus; article; controlled study; Herpes simplex virus 1; Herpes simplex virus 2; host cell; in vitro study; Junin virus; nonhuman; Pichinde arenavirus; priority journal; virus inactivation; virus morphogenesis; virus replication; Animals; Anti-Infective Agents; Antimicrobial Cationic Peptides; Cell Line; Cercopithecus aethiops; Cricetinae; Herpesvirus 1, Human; Herpesvirus 2, Human; Junin virus; Microbial Sensitivity Tests; Vero Cells; Virus Replication
Año:2004
Volumen:23
Número:4
Página de inicio:382
Página de fin:389
DOI: http://dx.doi.org/10.1016/j.ijantimicag.2003.07.022
Título revista:International Journal of Antimicrobial Agents
Título revista abreviado:Int. J. Antimicrob. Agents
ISSN:09248579
CODEN:IAAGE
CAS:cecropin A, 80451-04-3; indolicidin, 140896-21-5; magainin 1, 108433-99-4; magainin 2, 108433-95-0; melittin, 20449-79-0, 37231-28-0, 65742-02-1; protein, 67254-75-5; Anti-Infective Agents; Antimicrobial Cationic Peptides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09248579_v23_n4_p382_AlbiolMatanic

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Citas:

---------- APA ----------
Albiol Matanic, V.C. & Castilla, V. (2004) . Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. International Journal of Antimicrobial Agents, 23(4), 382-389.
http://dx.doi.org/10.1016/j.ijantimicag.2003.07.022
---------- CHICAGO ----------
Albiol Matanic, V.C., Castilla, V. "Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus" . International Journal of Antimicrobial Agents 23, no. 4 (2004) : 382-389.
http://dx.doi.org/10.1016/j.ijantimicag.2003.07.022
---------- MLA ----------
Albiol Matanic, V.C., Castilla, V. "Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus" . International Journal of Antimicrobial Agents, vol. 23, no. 4, 2004, pp. 382-389.
http://dx.doi.org/10.1016/j.ijantimicag.2003.07.022
---------- VANCOUVER ----------
Albiol Matanic, V.C., Castilla, V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int. J. Antimicrob. Agents. 2004;23(4):382-389.
http://dx.doi.org/10.1016/j.ijantimicag.2003.07.022