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Wachsman, M.O.B.; Farías, M.E.; Takeda, E.; Sesma, F.; De Ruiz Holgado, A.P.; De Torres, R.A.; Coto, C.E. "Antiviral activity of enterocin CRL35 against herpesviruses" (1999) International Journal of Antimicrobial Agents. 12(4):293-299
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Abstract:

Enterocin CRL35 is an antibacterial polypeptide of 3.5x103 Da produced by Enterococcus faecium CRL35. A series of experiments are described that show the enterocin also had antiviral activity against thymidine-kinase positive (tk+) and deficient (tk-) strains of herpes simplex (HSV) type 1 and 2 in Vero and BHK-21 cells. This activity was observed at 100 μg/ml, 15-fold lower than the cytotoxic concentration. In both cell lines there was a 2 log inhibition of infectivity. The compound inhibited viral multiplication in a dose-dependent manner and had no virucidal effect. Enterocin CRL35 also inhibited the virion-associated host shutoff in infected Vero cells showing that intracellular viral multiplication was affected. Copyright (C) 1999 Elsevier Science B.V.

Registro:

Documento: Artículo
Título:Antiviral activity of enterocin CRL35 against herpesviruses
Autor:Wachsman, M.O.B.; Farías, M.E.; Takeda, E.; Sesma, F.; De Ruiz Holgado, A.P.; De Torres, R.A.; Coto, C.E.
Filiación:Laboratorio de Virología, Dept. de Quím. Biol., Universidad de Buenos Aires, Pabellón 2, Piso 4, 1428 Buenos Aires, Argentina
Ctr. de Referencia para Lactobacilos, Chacabuco 145, 4000 Tucumán, Argentina
Laboratorio de Microbiología, Fac. de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, Piso 4, 1113 Buenos Aires, Argentina
Palabras clave:Antiviral; Bacteriocin; Enterococcus faecium; Herpes simplex type 1 and 2; bacteriocin; enterocin crl35; polypeptide; unclassified drug; animal cell; antiviral activity; article; cell strain bhk; controlled study; cytotoxicity; enterococcus faecium; hamster; herpes simplex virus 1; herpes simplex virus 2; herpes virus; monkey; nonhuman; priority journal; vero cell; virogenesis; Acyclovir; Animals; Antiviral Agents; Bacteriocins; Cell Line; Cell Survival; Cercopithecus aethiops; Chromatography, High Pressure Liquid; Cricetinae; Herpesvirus 1, Human; Herpesvirus 2, Human; Vero Cells
Año:1999
Volumen:12
Número:4
Página de inicio:293
Página de fin:299
DOI: http://dx.doi.org/10.1016/S0924-8579(99)00078-3
Título revista:International Journal of Antimicrobial Agents
Título revista abreviado:Int. J. Antimicrob. Agents
ISSN:09248579
CODEN:IAAGE
CAS:Acyclovir, 59277-89-3; Antiviral Agents; Bacteriocins; enterocin CRL35
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09248579_v12_n4_p293_Wachsman

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Citas:

---------- APA ----------
Wachsman, M.O.B., Farías, M.E., Takeda, E., Sesma, F., De Ruiz Holgado, A.P., De Torres, R.A. & Coto, C.E. (1999) . Antiviral activity of enterocin CRL35 against herpesviruses. International Journal of Antimicrobial Agents, 12(4), 293-299.
http://dx.doi.org/10.1016/S0924-8579(99)00078-3
---------- CHICAGO ----------
Wachsman, M.O.B., Farías, M.E., Takeda, E., Sesma, F., De Ruiz Holgado, A.P., De Torres, R.A., et al. "Antiviral activity of enterocin CRL35 against herpesviruses" . International Journal of Antimicrobial Agents 12, no. 4 (1999) : 293-299.
http://dx.doi.org/10.1016/S0924-8579(99)00078-3
---------- MLA ----------
Wachsman, M.O.B., Farías, M.E., Takeda, E., Sesma, F., De Ruiz Holgado, A.P., De Torres, R.A., et al. "Antiviral activity of enterocin CRL35 against herpesviruses" . International Journal of Antimicrobial Agents, vol. 12, no. 4, 1999, pp. 293-299.
http://dx.doi.org/10.1016/S0924-8579(99)00078-3
---------- VANCOUVER ----------
Wachsman, M.O.B., Farías, M.E., Takeda, E., Sesma, F., De Ruiz Holgado, A.P., De Torres, R.A., et al. Antiviral activity of enterocin CRL35 against herpesviruses. Int. J. Antimicrob. Agents. 1999;12(4):293-299.
http://dx.doi.org/10.1016/S0924-8579(99)00078-3