Abstract:
Azanone (HNO), also called nitroxyl, is a highly reactive compound, with interesting yet poorly understood biological properties. Like its closely related sibling NO, its main biological targets are heme proteins, although significant differences in their reactivity and pharmacological effects are observed. Due to its high reactivity, azanone studies rely on the use of donors, molecules that therefore offer interesting therapeutic perspectives. In this review, we firstly describe the pharmacological potential of azanone, the chemistry of the available donors, and the main biological relevant HNO reactions with special focus on heme proteins and metalloporphyrins (Fe, Mn, and Co). Finally, we present evidence concerning the endogenous . in vivo azanone production hypothesis, and how the recent porphyrin-based developed methods for its detection may contribute to solve this key physiological question. © 2012 Elsevier Inc.
Registro:
Documento: |
Artículo
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Título: | Azanone (HNO) interaction with Hemeproteins and metalloporphyrins |
Autor: | Doctorovich, F.; Bikiel, D.E.; Pellegrino, J.; Suárez, S.A.; Martí, M.A. |
Filiación: | Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE-CONICET, Buenos Aires, Argentina Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II (1428), Buenos Aires, Argentina
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Palabras clave: | Azanone; Cobalt; Heme; HNO; Iron; Kinetics; Manganese; Myoglobin; Nitrosyl; Nitroxyl; Nitroxyl anion; NO; NOS; Oxidation; Porphyrin; Protein; Reductive nitrosylation; Ruthenium |
Año: | 2012
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Volumen: | 64
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Página de inicio: | 97
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Página de fin: | 139
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DOI: |
http://dx.doi.org/10.1016/B978-0-12-396462-5.00004-0 |
Título revista: | Advances in Inorganic Chemistry
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Título revista abreviado: | Adv. Inorg. Chem.
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ISSN: | 08988838
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08988838_v64_n_p97_Doctorovich |
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Citas:
---------- APA ----------
Doctorovich, F., Bikiel, D.E., Pellegrino, J., Suárez, S.A. & Martí, M.A.
(2012)
. Azanone (HNO) interaction with Hemeproteins and metalloporphyrins. Advances in Inorganic Chemistry, 64, 97-139.
http://dx.doi.org/10.1016/B978-0-12-396462-5.00004-0---------- CHICAGO ----------
Doctorovich, F., Bikiel, D.E., Pellegrino, J., Suárez, S.A., Martí, M.A.
"Azanone (HNO) interaction with Hemeproteins and metalloporphyrins"
. Advances in Inorganic Chemistry 64
(2012) : 97-139.
http://dx.doi.org/10.1016/B978-0-12-396462-5.00004-0---------- MLA ----------
Doctorovich, F., Bikiel, D.E., Pellegrino, J., Suárez, S.A., Martí, M.A.
"Azanone (HNO) interaction with Hemeproteins and metalloporphyrins"
. Advances in Inorganic Chemistry, vol. 64, 2012, pp. 97-139.
http://dx.doi.org/10.1016/B978-0-12-396462-5.00004-0---------- VANCOUVER ----------
Doctorovich, F., Bikiel, D.E., Pellegrino, J., Suárez, S.A., Martí, M.A. Azanone (HNO) interaction with Hemeproteins and metalloporphyrins. Adv. Inorg. Chem. 2012;64:97-139.
http://dx.doi.org/10.1016/B978-0-12-396462-5.00004-0