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Abstract:

Incubation of rat adrenal glomerulosa cells with low concentrations (up to 50 nM) of the protein kinase (PKC) inhibitor staurosporine (ST) inhibited aldosterone (ALDO) and cyclic AMP (cAMP) production stimulated by adrenocorticotropic hormone (ACTH) and cholera toxin. Only higher concentrations (1.6 μM) of staurosporine inhibited dibutyryl-cAMP-and forskolin-induced stimulation of aldosterone production. cAMP levels were increased only with low concentrations of the PKC inhibitor. This latter increase was avoided by treatment with a maximal concentration of isobutylmethylxanthine (MIX). Our results suggest that: (1) second messengers other than cAMP are involved in ACTH action; (2) staurosporine inhibits different kinases involved in ACTH action in a dose dependent manner; (3) the protein kinase inhibited by high concentrations of staurosporine appears to be the cAMP dependent kinase, PKA; and (4) the protein kinase inhibited by low concentrations of staurosporine remains to be identified. This latter species is suggested as being involved in mediating ACTH-induced activation of Gs.

Registro:

Documento: Artículo
Título:Effects of staurosporine on ACTH-mediated stimulation of aldosterone production
Autor:Pecci, A.; Romero, D.G.; Gomez-Sanchez, C.E.; Lantos, C.P.; Cozza, E.N.
Filiación:Departamento de Quimica Biologica, Fac. de Ciencias Exactas y Naturales, Univ. de Buenos Aires/PRHOM-CONICET, 1428 Buenos Aires, Argentina
Department of Internal Medicine, Harry S. Truman Mem. Vet.' Hospital, University of Missouri-Columbia, Columbia, MO, United States
Palabras clave:Adrenocorticotropin; Aldosterone; Staurosporine; aldosterone; bucladesine; cholera toxin; corticotropin; cyclic AMP; cyclic AMP dependent protein kinase; isobutylmethylxanthine; protein kinase; protein kinase C inhibitor; staurosporine; stimulatory guanine nucleotide binding protein; animal cell; animal tissue; article; controlled study; enzyme inhibition; hormone synthesis; male; nonhuman; priority journal; rat; second messenger; zona glomerulosa; Animalia
Año:1996
Volumen:8
Número:5
Página de inicio:381
Página de fin:386
DOI: http://dx.doi.org/10.1016/0898-6568(96)00081-2
Título revista:Cellular Signalling
Título revista abreviado:CELL. SIGNAL.
ISSN:08986568
CODEN:CESIE
CAS:aldosterone, 52-39-1, 6251-69-0; bucladesine, 16980-89-5, 362-74-3; corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; cyclic AMP, 60-92-4; cyclic AMP dependent protein kinase; isobutylmethylxanthine, 28822-58-4; protein kinase, 9026-43-1; staurosporine, 62996-74-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08986568_v8_n5_p381_Pecci

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Citas:

---------- APA ----------
Pecci, A., Romero, D.G., Gomez-Sanchez, C.E., Lantos, C.P. & Cozza, E.N. (1996) . Effects of staurosporine on ACTH-mediated stimulation of aldosterone production. Cellular Signalling, 8(5), 381-386.
http://dx.doi.org/10.1016/0898-6568(96)00081-2
---------- CHICAGO ----------
Pecci, A., Romero, D.G., Gomez-Sanchez, C.E., Lantos, C.P., Cozza, E.N. "Effects of staurosporine on ACTH-mediated stimulation of aldosterone production" . Cellular Signalling 8, no. 5 (1996) : 381-386.
http://dx.doi.org/10.1016/0898-6568(96)00081-2
---------- MLA ----------
Pecci, A., Romero, D.G., Gomez-Sanchez, C.E., Lantos, C.P., Cozza, E.N. "Effects of staurosporine on ACTH-mediated stimulation of aldosterone production" . Cellular Signalling, vol. 8, no. 5, 1996, pp. 381-386.
http://dx.doi.org/10.1016/0898-6568(96)00081-2
---------- VANCOUVER ----------
Pecci, A., Romero, D.G., Gomez-Sanchez, C.E., Lantos, C.P., Cozza, E.N. Effects of staurosporine on ACTH-mediated stimulation of aldosterone production. CELL. SIGNAL. 1996;8(5):381-386.
http://dx.doi.org/10.1016/0898-6568(96)00081-2