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Abstract:

We describe the effect of an inositol phosphoglycan (IPG) purified from Trypanosoma cruzi on the stimulation of aldosterone and cAMP production by ACTH in calf adrenocortical cells. T. cruzi IPG has two galactofuranose residues (Galf) which are not frequent in other IPGs. The effect of IPG with galactofuranose residues (IPG Galf) and IPG without these residues (IPG) was investigated. It was found that IPG Galf slightly decreased the stimulation of aldosterone and cAMP production by ACTH, whereas IPG significantly inhibited ACTH-mediated accumulation of both aldosterone and cAMP. The inhibition of aldosterone content in ACTH-treated cells by IPG was dose dependent. It was also found that the pretreatment of calf adrenocortical cells with IPG inhibited the accumulation of aldosterone provoked by ACTH and dibutyryladenosine-3′,5′-cyclic monophosphate (db-cAMP). On the other hand, the activation of a GPI (glycosyl phosphatidylinositol)-phospholipase C by ACTH was evaluated. First it was found that the release of ceramide from a GPI-like molecule: a glycoinositol-phosphoceramide (LPPG) purified from T. cruzi is increased in ACTH-treated cells. Second, the release of alkaline phosphatase, a GPI-anchored enzyme, to the extracellular medium was increased in these cells by ACTH. These data suggest that ACTH activates a phospholipase C in calf adrenocortical cells, releasing IPG, which in turn may inhibit, or modulate ACTH action. © 1995.

Registro:

Documento: Artículo
Título:An inositol phosphoglycan from Trypanosoma cruzi inhibits ACTH action in calf adrenocortical cells
Autor:Vila, M.D.C.; Cozza, E.N.; Lima, C.; Ramirez, M.I.; De Lederkremer, R.M.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Palabras clave:ACTH; aldosterone biosynthesis; Glycosyl-phosphatidylinositol; aldosterone; corticotropin; cyclic amp; glucosamine; glycan derivative; phosphatidylinositol; phospholipase c; adrenal cortex cell; aldosterone release; animal cell; article; controlled study; hydrolysis; nonhuman; phospholipid metabolism; priority journal; trypanosoma cruzi; Adrenal Cortex; Aldosterone; Alkaline Phosphatase; Animal; Bucladesine; Carbohydrate Sequence; Cattle; Cells, Cultured; Corticotropin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Glycosphingolipids; Hormone Antagonists; Inositol Phosphates; Molecular Sequence Data; Phospholipase C; Phosphoric Diester Hydrolases; Polysaccharides; Support, Non-U.S. Gov't; Trypanosoma cruzi
Año:1995
Volumen:7
Número:4
Página de inicio:331
Página de fin:339
DOI: http://dx.doi.org/10.1016/0898-6568(95)00008-D
Título revista:Cellular Signalling
Título revista abreviado:Cell. Signal.
ISSN:08986568
CODEN:CESIE
CAS:aldosterone, 52-39-1, 6251-69-0; corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; cyclic AMP, 60-92-4; glucosamine, 3416-24-8, 4607-22-1; phospholipase C, 9001-86-9; 1-phosphatidylinositol phosphodiesterase, EC 3.1.4.10; Aldosterone, 52-39-1; Alkaline Phosphatase, EC 3.1.3.1; Bucladesine, 362-74-3; Corticotropin, 9002-60-2; Cyclic AMP, 60-92-4; Glycosphingolipids; Hormone Antagonists; inositol phosphate glycan; Inositol Phosphates; lipophosphonoglycan; Phospholipase C, EC 3.1.4.3; Phosphoric Diester Hydrolases, EC 3.1.4; Polysaccharides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08986568_v7_n4_p331_Vila

Referencias:

  • Doering, Masterson, Hart, Englund, (1990) J. biol. Chem., 265, pp. 611-614
  • Ferguson, (1992) Biochem. Soc. Trans., 20, pp. 243-256
  • Mato, (1989) Cell. Signal., 1, pp. 143-146
  • Saltiel, Fox, Sherline, Cuatrecasas, (1986) Science, 233, pp. 967-972
  • Vila, Milligan, Standaert, Farese, (1990) Biochemistry, 29, pp. 8735-8740
  • Romero, Gamez, Huang, Lilley, Luttrell, (1990) Proc. natn. Acad. Sci. U.S.A., 87, pp. 1476-1480. , 3rd edn
  • Misek, Saltiel, (1992) J. biol. Chem., 267, pp. 16266-16273
  • Deeg, Brass, Rosenberry, (1993) Diabetes, 42, pp. 1318-1323
  • Romero, Luttrell, Rogol, Zeller, Hewlett, Larner, (1988) Science, 240, pp. 509-511
  • Mato, Kelly, Abler, Jarret, (1987) J. biol. Chem., 262, pp. 2131-2137
  • Merida, Pratt, Gaulton, (1990) Proc. natn. Acad. Sci. U.S.A., 87, pp. 9421-9425. , 3rd edn
  • Saltiel, (1987) Endocrinology, 120, pp. 967-972
  • Martiny, Dib, Haye, Correze, Jacquemin, Lambert, (1991) FEBS Lett., 286, pp. 105-109
  • Villalba, Kelly, Mato, (1988) Biochim. biophys. Acta, 968, pp. 69-76
  • Alvarez, Cabello, Felíu, Mato, (1987) Biochem. biophys. Res. Commun., 147, pp. 765-771
  • Alemany, Mato, Stralfors, (1987) Nature, 330, pp. 77-79
  • Represa, Avila, Miner, Giraldez, Romero, Clemente, Mato, Varela-Nieto, (1991) Proc. natn. Acad. Sci. U.S.A., 88, pp. 8016-8019. , 3rd edn
  • Eardly, Koshland, (1991) Science, 251, pp. 78-81
  • Martiny, Antonicelli, Thuilliez, Lambert, Jacquemin, Haye, (1990) Cell. Signal., 2, pp. 21-27
  • Igarashi, Chambaz, (1987) Biochem. biophys. Res. Commun., 145, pp. 249-256
  • Cozza, Vila, Gomez-Sanchez, Farese, (1988) Biochem. biophys. Res. Commun., 157, pp. 585-589
  • Lederkremer, Lima, Ramirez, Casal, (1990) Eur. J. Biochem., 192, pp. 337-345
  • Lederkremer, Lima, Ramirez, Ferguson, Homans, Thomas-Oates, (1991) J. biol. Chem., 266, pp. 23670-23675
  • Gomez-Sanchez, Foecking, Ferris, Chavarri, Uribe, Gomez-Sanchez, The production of monoclonal antibodies against aldosterone (1987) Steroids, 49, pp. 581-587
  • Steiner, Parker, Kipnis, (1972) J. biol. Chem., 247, pp. 1106-1113
  • Lederkremer, Lima, Ramirez, Goncalvez, Colli, (1993) Eur. J. Biochem., 218, pp. 929-936
  • Lederkremer, Casal, Alves, Colli, Evidence for the presence of D-galactofuranose in the lipopeptidophosphoglycan from Trypanosoma cruzi (1980) FEBS Letters, 116, pp. 25-29
  • Roberts, Kenton, Johnson, (1990) FEBS Lett., 267, pp. 213-216
  • Fox, Duszenko, Ferguson, Low, Cross, (1986) J. biol. Chem., 261, pp. 15767-15771
  • Fox, Soliz, Saltiel, (1987) Proc. natn. Acad. Sci. U.S.A., 84, pp. 2663-2667. , 3rd edn
  • Alvarez, Sanchez-Arias, Guadaño, Estévez, Varela, Felíu, Mato, (1991) Biochem. J., 274, pp. 369-374
  • Klein, Andersen, Casson, Buster, Kramer, (1992) J. Steroid. Biochem. Molec. Biol., 41, pp. 11-20

Citas:

---------- APA ----------
Vila, M.D.C., Cozza, E.N., Lima, C., Ramirez, M.I. & De Lederkremer, R.M. (1995) . An inositol phosphoglycan from Trypanosoma cruzi inhibits ACTH action in calf adrenocortical cells. Cellular Signalling, 7(4), 331-339.
http://dx.doi.org/10.1016/0898-6568(95)00008-D
---------- CHICAGO ----------
Vila, M.D.C., Cozza, E.N., Lima, C., Ramirez, M.I., De Lederkremer, R.M. "An inositol phosphoglycan from Trypanosoma cruzi inhibits ACTH action in calf adrenocortical cells" . Cellular Signalling 7, no. 4 (1995) : 331-339.
http://dx.doi.org/10.1016/0898-6568(95)00008-D
---------- MLA ----------
Vila, M.D.C., Cozza, E.N., Lima, C., Ramirez, M.I., De Lederkremer, R.M. "An inositol phosphoglycan from Trypanosoma cruzi inhibits ACTH action in calf adrenocortical cells" . Cellular Signalling, vol. 7, no. 4, 1995, pp. 331-339.
http://dx.doi.org/10.1016/0898-6568(95)00008-D
---------- VANCOUVER ----------
Vila, M.D.C., Cozza, E.N., Lima, C., Ramirez, M.I., De Lederkremer, R.M. An inositol phosphoglycan from Trypanosoma cruzi inhibits ACTH action in calf adrenocortical cells. Cell. Signal. 1995;7(4):331-339.
http://dx.doi.org/10.1016/0898-6568(95)00008-D