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Abstract:

The mast cell product tryptase, via protease-activated receptor 2 (PAR2), induces cyclooxygenase-2 (COX2) and 15-deoxy-prostaglandin J2 (15d-PGJ2) synthesis. 15d-PGJ2, through the nuclear peroxisome proliferator activated receptor gamma (PPARγ), subsequently causes fibroblast proliferation. In this study we attempted to determine initial events of the tryptase/PAR2 signaling pathway leading to COX2 induction and fibroblast proliferation. In human fibroblasts (HFFF2), cDNA array, RT-PCR and Western blotting studies demonstrated that tryptase, but not 15d-PGJ2, up-regulates c-jun, c-fos and COX2 expression, and phosphorylates the extracellular signal-regulated kinase isoforms 1 and 2 (erk1/2). Furthermore, tryptase effects on erk1/2, c-jun, c-fos, COX2 and cell proliferation were prevented by PD98059, an inhibitor of the mitogen-activated protein kinase kinase (MEK). Other kinases [P38, stress-activated protein kinase/c-jun N-terminal kinase (SAPK/JUNK), erk5], intracellular Ca 2+ or cAMP were not affected by tryptase/PAR2. Our study identifies crucial intracellular events leading to induction of COX2 and fibroblast proliferation, i.e. a cornerstone of fibrosis. © 2004 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:The action of the mast cell product tryptase on cyclooxygenase-2 (COX2) and subsequent fibroblast proliferation involves activation of the extracellular signal-regulated kinase isoforms 1 and 2 (erk1/2)
Autor:Frungieri, M.B.; Albrecht, M.; Raemsch, R.; Mayerhofer, A.
Filiación:Anatomical Institute, Ludwig Maximilians University, D-80802 Munich, Germany, Germany
Inst. de Biol. Y Med. Experimental, CONICET, 1428 Buenos Aires, Argentina, Argentina
Inst. de Biol. Y Med. Experimental, CONICET, 1428 Buenos Aires, Argentina., Argentina
Palabras clave:Ca 2+; cAMP; Cyclooxygenase-2; MAP kinases; Transcription factors; Tryptase; 2 (2 amino 3 methoxyphenyl)chromone; cyclooxygenase 2; mitogen activated protein kinase 1; mitogen activated protein kinase inhibitor; phosphotransferase; prostaglandin derivative; protein c fos; stress activated protein kinase; tryptase; article; calcium cell level; cell proliferation; controlled study; DNA microarray; enzyme activation; enzyme activity; enzyme induction; enzyme mechanism; fibroblast; human; human cell; mast cell; priority journal; protein expression; protein phosphorylation; reverse transcription polymerase chain reaction; signal transduction; upregulation; Western blotting; Base Sequence; Calcium; Cell Proliferation; Cyclic AMP; Cyclooxygenase 2; Fibroblasts; Humans; Male; Mast Cells; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Sequence Data; Prostaglandin-Endoperoxide Synthases; Protein Isoforms; Serine Endopeptidases; Signal Transduction; Tryptases; Up-Regulation
Año:2005
Volumen:17
Número:4
Página de inicio:525
Página de fin:533
DOI: http://dx.doi.org/10.1016/j.cellsig.2004.09.017
Título revista:Cellular Signalling
Título revista abreviado:Cell. Signal.
ISSN:08986568
CODEN:CESIE
CAS:2 (2 amino 3 methoxyphenyl)chromone, 167869-21-8; mitogen activated protein kinase 1, 137632-08-7; phosphotransferase, 9031-09-8, 9031-44-1; stress activated protein kinase, 155215-87-5; tryptase, 97501-93-4; Calcium, 7440-70-2; Cyclic AMP, 60-92-4; Cyclooxygenase 2, 1.14.99.1; Membrane Proteins; Mitogen-Activated Protein Kinase 1, 2.7.1.37; Mitogen-Activated Protein Kinase 3, 2.7.1.37; PTGS2 protein, human, 1.14.99.1; Prostaglandin-Endoperoxide Synthases, 1.14.99.1; Protein Isoforms; Serine Endopeptidases, 3.4.21.-; Tryptases, 3.4.21.59
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08986568_v17_n4_p525_Frungieri

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Citas:

---------- APA ----------
Frungieri, M.B., Albrecht, M., Raemsch, R. & Mayerhofer, A. (2005) . The action of the mast cell product tryptase on cyclooxygenase-2 (COX2) and subsequent fibroblast proliferation involves activation of the extracellular signal-regulated kinase isoforms 1 and 2 (erk1/2). Cellular Signalling, 17(4), 525-533.
http://dx.doi.org/10.1016/j.cellsig.2004.09.017
---------- CHICAGO ----------
Frungieri, M.B., Albrecht, M., Raemsch, R., Mayerhofer, A. "The action of the mast cell product tryptase on cyclooxygenase-2 (COX2) and subsequent fibroblast proliferation involves activation of the extracellular signal-regulated kinase isoforms 1 and 2 (erk1/2)" . Cellular Signalling 17, no. 4 (2005) : 525-533.
http://dx.doi.org/10.1016/j.cellsig.2004.09.017
---------- MLA ----------
Frungieri, M.B., Albrecht, M., Raemsch, R., Mayerhofer, A. "The action of the mast cell product tryptase on cyclooxygenase-2 (COX2) and subsequent fibroblast proliferation involves activation of the extracellular signal-regulated kinase isoforms 1 and 2 (erk1/2)" . Cellular Signalling, vol. 17, no. 4, 2005, pp. 525-533.
http://dx.doi.org/10.1016/j.cellsig.2004.09.017
---------- VANCOUVER ----------
Frungieri, M.B., Albrecht, M., Raemsch, R., Mayerhofer, A. The action of the mast cell product tryptase on cyclooxygenase-2 (COX2) and subsequent fibroblast proliferation involves activation of the extracellular signal-regulated kinase isoforms 1 and 2 (erk1/2). Cell. Signal. 2005;17(4):525-533.
http://dx.doi.org/10.1016/j.cellsig.2004.09.017