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Abstract:

Traditionally, it was accepted that long-term hormone replacement therapy (HRT) has a cardiovascular beneficial effect in postmenopausal women with and without coronary artery disease (CAD). However, randomized trials in postmenopausal women have not shown any benefit in either primary or secondary prevention of cardiovascular events. Therefore, these findings have raised the question of whether traditional HRT (i.e., estrogen and progesterone) has a cardioprotective effect in women at risk for or with established CAD. Concerns about the use of conventional HRT have led to a search for alternatives. Tibolone is a synthetic compound with estrogenic, androgenic, and progestogenic properties that relieves climacteric symptoms and prevents postmenopausal bone loss. Tibolone possesses a tissue-selective mechanism of action that differs from that of estrogen and/or progestogen. Unlike these compounds, tibolone's metabolites play a central role in its mode of action. Tibolone is widely used for HRT. However, its clinical impact on cardiovascular disease is still under study. The current review focuses on the effects of tibolone on the cardiovascular system and discusses clinical investigations with this compound in postmenopausal women. © 2007 The Authors.

Registro:

Documento: Artículo
Título:Cardiovascular effects of tibolone: A selective tissue estrogenic activity regulator
Autor:Campisi, R.; Marengo, F.D.
Filiación:Fundación Centro Diagnóstico Nuclear, Instituto Argentino de Diagnóstico Y Tratamiento S.A., Argentina
Laboratorio de Fisiología Y Biología Molecular, Departamento de Fisiología Y Biología Molecular Y Celular, IFIBYNE-CONICET, Buenos Aires, Argentina
Fundación Centro Diagnóstico Nuclear, Av. Nazca 3449, Capital Federal (1417), Buenos Aires, Argentina
Palabras clave:Atherosclerosis; Endothelial function; Heart disease; Menopause; Tibolone; 3 alpha hydroxytibolone; 3 beta hydroxytibolone; C reactive protein; conjugated estrogen plus medroxyprogesterone acetate; drug metabolite; endothelial leukocyte adhesion molecule 1; estradiol plus norethisterone acetate; estrogen; estrogen receptor alpha; estrogen receptor beta; high density lipoprotein cholesterol; homocysteine; intercellular adhesion molecule 1; nitrate; nitric oxide; nitrite; progesterone; tibolone; unclassified drug; vascular cell adhesion molecule 1; abdominal pain; antiinflammatory activity; artery intima proliferation; atherosclerosis; blood clotting; cardiovascular disease; cardiovascular effect; cardiovascular system; cholesterol blood level; chronotropism; clinical trial; coronary artery disease; coronary risk; drug blood level; drug mechanism; drug metabolism; estrogen activity; heart arrhythmia; heart muscle ischemia; heart protection; hormone substitution; human; inflammation; kidney function; leukorrhea; liver function; mastalgia; nonhuman; postmenopause; primary prevention; priority journal; review; secondary prevention; side effect; tissue specificity; vagina bleeding; vascular endothelium; vasodilatation; venous thromboembolism; weight gain; Animals; Atherosclerosis; Blood Coagulation; Cardiovascular System; Coronary Disease; Estrogen Receptor Modulators; Female; Humans; Menopause; Middle Aged; Norpregnenes; Tunica Intima
Año:2007
Volumen:25
Número:2
Página de inicio:132
Página de fin:145
DOI: http://dx.doi.org/10.1111/j.1527-3466.2007.00007.x
Título revista:Cardiovascular Drug Reviews
Título revista abreviado:Cardiovasc. Drug Rev.
ISSN:08975957
CODEN:CDREE
CAS:C reactive protein, 9007-41-4; endothelial leukocyte adhesion molecule 1, 128875-25-2; homocysteine, 454-28-4, 6027-13-0; intercellular adhesion molecule 1, 126547-89-5; nitrate, 14797-55-8; nitric oxide, 10102-43-9; nitrite, 14797-65-0; progesterone, 57-83-0; tibolone, 5630-53-5; Estrogen Receptor Modulators; Norpregnenes; tibolone, 5630-53-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08975957_v25_n2_p132_Campisi

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Citas:

---------- APA ----------
Campisi, R. & Marengo, F.D. (2007) . Cardiovascular effects of tibolone: A selective tissue estrogenic activity regulator. Cardiovascular Drug Reviews, 25(2), 132-145.
http://dx.doi.org/10.1111/j.1527-3466.2007.00007.x
---------- CHICAGO ----------
Campisi, R., Marengo, F.D. "Cardiovascular effects of tibolone: A selective tissue estrogenic activity regulator" . Cardiovascular Drug Reviews 25, no. 2 (2007) : 132-145.
http://dx.doi.org/10.1111/j.1527-3466.2007.00007.x
---------- MLA ----------
Campisi, R., Marengo, F.D. "Cardiovascular effects of tibolone: A selective tissue estrogenic activity regulator" . Cardiovascular Drug Reviews, vol. 25, no. 2, 2007, pp. 132-145.
http://dx.doi.org/10.1111/j.1527-3466.2007.00007.x
---------- VANCOUVER ----------
Campisi, R., Marengo, F.D. Cardiovascular effects of tibolone: A selective tissue estrogenic activity regulator. Cardiovasc. Drug Rev. 2007;25(2):132-145.
http://dx.doi.org/10.1111/j.1527-3466.2007.00007.x