Artículo
Janson, J.J.; Galarza, C.R.; Murúa, A.; Quintana, I.; Przygoda, P.A.; Waisman, G.; Camera, L.; Kordich, L.; Morales, M.; Mayorga, L.M.; Camera, M.I. "Prevalence of hyperhomocysteinemia in an elderly population" (2002) American Journal of Hypertension. 15(5):394-397
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Abstract:
Background: Currently, total hyperhomocysteinemia (tHHcy) is a well-known condition linked to a higher risk of vascular disease. Prevalence of HHcy increases in elderly persons as the risk associated with it persists. Because factors can be potentially reduced in the elderly, it is important to carry out epidemiologic studies of HHcy. Procedure: Previously we described the prevalence of hypertension control in an elder population; now, in an observational cross-sectional simple blind study, total homocysteine (tHcy) concentration was determined in 196 of 400 patients from the original cohort. Results: Mean Hcy concentration was 13.2 μmol/L (95% confidence interval 12.4-14.0; range, 5.0 to 48.9); 15.0 μmol/L for men and 12.3 μmol/L for women. Mean serum folic acid levels were 4.9 ± 3.1 ng/mL (range, 2.0 to 20.0 ng/mL), and vitamin B12 levels were 384.8 ± 314.1 pg/mL (range, 48.0 to 1500.0 pg/mL). Taking into account the reference values established by the Third National Health and Nutrition Examination Survey III study, HHcy was detected in 69.8% of all the subjects evaluated. The study showed that 76.2% of the men and 66.4% of the women had high Hcy levels. Conclusions: The very high prevalence of tHHcy in the elderly population, and the consequent risks associated with it suggest that although there are no trials that effectively prove the benefit of tHcy decrease, nutritional intervention is still justified. © 2002 American Journal of Hypertension, Ltd.
Registro:
| Documento: | Artículo |
| Título: | Prevalence of hyperhomocysteinemia in an elderly population |
| Autor: | Janson, J.J.; Galarza, C.R.; Murúa, A.; Quintana, I.; Przygoda, P.A.; Waisman, G.; Camera, L.; Kordich, L.; Morales, M.; Mayorga, L.M.; Camera, M.I. |
| Filiación: | Sociedad Argentina de Medicina Vascular, Buenos Aires, Argentina Facultad de Ciencias Exactas y Naturales, UBA, Buenos Aires, Argentina Hospital Italiano de Buenos Aires, Servicio de Clinica Medica y Unidad de Hipertension Arterial, Buenos Aires, Argentina Unidad de Hipertension Arterial, Hospital Italiano de Buenos Aires, Gascon 450, (1181) Buenos Aires, Argentina |
| Palabras clave: | Elderly people; Epidemiologic studies; Homocysteine; Prevalence; folic acid; homocysteine; aged; article; female; folic acid blood level; human; hyperhomocysteinemia; major clinical study; male; nutrition; prevalence; priority journal; reference value; risk factor; statistical analysis; vascular disease; vitamin blood level; Age Distribution; Aged; Aged, 80 and over; Cohort Studies; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Prevalence; Sex Distribution; Vitamin B 12 |
| Año: | 2002 |
| Volumen: | 15 |
| Número: | 5 |
| Página de inicio: | 394 |
| Página de fin: | 397 |
| DOI: | http://dx.doi.org/10.1016/S0895-7061(01)02165-3 |
| Título revista: | American Journal of Hypertension |
| Título revista abreviado: | Am. J. Hypertens. |
| ISSN: | 08957061 |
| CODEN: | AJHYE |
| CAS: | Folic Acid, 59-30-3; Homocysteine, 454-28-4; Vitamin B 12, 68-19-9 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08957061_v15_n5_p394_Janson |
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Citas:
---------- APA ----------
Janson, J.J., Galarza, C.R., Murúa, A., Quintana, I., Przygoda, P.A., Waisman, G., Camera, L.,..., Camera, M.I. (2002) . Prevalence of hyperhomocysteinemia in an elderly population. American Journal of Hypertension, 15(5), 394-397.http://dx.doi.org/10.1016/S0895-7061(01)02165-3
---------- CHICAGO ----------
Janson, J.J., Galarza, C.R., Murúa, A., Quintana, I., Przygoda, P.A., Waisman, G., et al. "Prevalence of hyperhomocysteinemia in an elderly population" . American Journal of Hypertension 15, no. 5 (2002) : 394-397.http://dx.doi.org/10.1016/S0895-7061(01)02165-3
---------- MLA ----------
Janson, J.J., Galarza, C.R., Murúa, A., Quintana, I., Przygoda, P.A., Waisman, G., et al. "Prevalence of hyperhomocysteinemia in an elderly population" . American Journal of Hypertension, vol. 15, no. 5, 2002, pp. 394-397.http://dx.doi.org/10.1016/S0895-7061(01)02165-3
---------- VANCOUVER ----------
Janson, J.J., Galarza, C.R., Murúa, A., Quintana, I., Przygoda, P.A., Waisman, G., et al. Prevalence of hyperhomocysteinemia in an elderly population. Am. J. Hypertens. 2002;15(5):394-397.http://dx.doi.org/10.1016/S0895-7061(01)02165-3
