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Petracca, G.; Tesón, A.; Chemerinski, E.; Leiguarda, R.; Starkstein, S.E. "A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease" (1996) Journal of Neuropsychiatry and Clinical Neurosciences. 8(3):270-275
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Abstract:

Twenty-one depressed patients with probable Alzheimer's disease (AD) were randomized to receive a 6-week treatment with clomipramine or placebo in a study with a double-blind crossover design. Main outcome measures were Hamilton Depression, Mini-Mental State (MMSE), and Functional Independence Measure (FIM) scores. Mood improved significantly on both clomipramine and placebo, but clomipramine was significantly more effective than placebo during the first 6-week treatment period. Patients started on clomipramine maintained improvement during the washout and placebo periods, whereas patients started on placebo worsened during the washout period. However, patients on clomipramine showed significantly lower MMSE scores overall than patients on placebo. No significant drug effects were found on FIM scores. Clomipramine proved to be a useful treatment of depression in patients with probable AD.

Registro:

Documento: Artículo
Título:A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease
Autor:Petracca, G.; Tesón, A.; Chemerinski, E.; Leiguarda, R.; Starkstein, S.E.
Filiación:Department of Neuropsychiatry, Raul Carrea Inst. of Neurol. Res., Buenos Aires, Argentina
Inst. Invest. Neurologicas Raul C., Montañeses 2325, 1428 Buenos Aires, Argentina
Palabras clave:clomipramine; tricyclic antidepressant agent; adult; aged; Alzheimer disease; article; clinical article; clinical trial; confusion; constipation; controlled clinical trial; controlled study; crossover procedure; depression; double blind procedure; drug efficacy; female; functional assessment; Hamilton scale; headache; human; male; mood; nausea; oral drug administration; priority journal; randomized controlled trial; sleep disorder; stomach pain; time; treatment outcome; tremor; vertigo
Año:1996
Volumen:8
Número:3
Página de inicio:270
Página de fin:275
DOI: http://dx.doi.org/10.1176/jnp.8.3.270
Título revista:Journal of Neuropsychiatry and Clinical Neurosciences
Título revista abreviado:J. NEUROPSYCHIATRY CLIN. NEUROSCI.
ISSN:08950172
CODEN:JNCNE
CAS:clomipramine, 17321-77-6, 303-49-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08950172_v8_n3_p270_Petracca

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Citas:

---------- APA ----------
Petracca, G., Tesón, A., Chemerinski, E., Leiguarda, R. & Starkstein, S.E. (1996) . A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease. Journal of Neuropsychiatry and Clinical Neurosciences, 8(3), 270-275.
http://dx.doi.org/10.1176/jnp.8.3.270
---------- CHICAGO ----------
Petracca, G., Tesón, A., Chemerinski, E., Leiguarda, R., Starkstein, S.E. "A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease" . Journal of Neuropsychiatry and Clinical Neurosciences 8, no. 3 (1996) : 270-275.
http://dx.doi.org/10.1176/jnp.8.3.270
---------- MLA ----------
Petracca, G., Tesón, A., Chemerinski, E., Leiguarda, R., Starkstein, S.E. "A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease" . Journal of Neuropsychiatry and Clinical Neurosciences, vol. 8, no. 3, 1996, pp. 270-275.
http://dx.doi.org/10.1176/jnp.8.3.270
---------- VANCOUVER ----------
Petracca, G., Tesón, A., Chemerinski, E., Leiguarda, R., Starkstein, S.E. A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease. J. NEUROPSYCHIATRY CLIN. NEUROSCI. 1996;8(3):270-275.
http://dx.doi.org/10.1176/jnp.8.3.270