Artículo
Abstract:
The authors examined the presence of significant regional cerebral blood flow (rCBF) differences between Alzheimer's disease (AD) patients with and without extrapyramidal signs (EPS). Nine patients with probable AD and EPS (resting tremor or rigidity and bradykinesia) and 9 AD patients without EPS, comparable in age, duration of illness, and global cognitive decline, were studied with [99mTc]HMPAO SPECT. Patients with AD and EPS showed significantly lower rCBF in the superior frontal, superior temporal, and parietal regions of the left hemisphere than AD patients without EPS. Rigidity and bradykinesia independently accounted for the decreased rCBF in these areas. These findings suggest that the presence of EPS in AD may result from dysfunction in specific brain regions.
Registro:
| Documento: | Artículo |
| Título: | A SPECT study of Parkinsonism in Alzheimer's disease |
| Autor: | Starkstein, S.E.; Vazquez, S.; Merello, M.; Teson, A.; Petracchi, M.; Leiguarda, R. |
| Filiación: | Inst Investig Neurolog Raul Carrea, Montaneses 2325, 1428 Buenos Aires, Argentina |
| Palabras clave: | hexamethylpropylene amine oxime technetium tc 99m; aged; Alzheimer disease; article; bradykinesia; brain blood flow; clinical article; cognitive defect; extrapyramidal symptom; female; frontal lobe; human; left hemisphere; male; parietal lobe; parkinsonism; priority journal; rigidity; single photon emission computer tomography; temporal lobe; tremor |
| Año: | 1995 |
| Volumen: | 7 |
| Número: | 3 |
| Página de inicio: | 308 |
| Página de fin: | 313 |
| DOI: | http://dx.doi.org/10.1176/jnp.7.3.308 |
| Título revista: | Journal of Neuropsychiatry and Clinical Neurosciences |
| Título revista abreviado: | J. NEUROPSYCHIATRY CLIN. NEUROSCI. |
| ISSN: | 08950172 |
| CODEN: | JNCNE |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08950172_v7_n3_p308_Starkstein |
Citas:
---------- APA ----------
Starkstein, S.E., Vazquez, S., Merello, M., Teson, A., Petracchi, M. & Leiguarda, R. (1995) . A SPECT study of Parkinsonism in Alzheimer's disease. Journal of Neuropsychiatry and Clinical Neurosciences, 7(3), 308-313.http://dx.doi.org/10.1176/jnp.7.3.308
---------- CHICAGO ----------
Starkstein, S.E., Vazquez, S., Merello, M., Teson, A., Petracchi, M., Leiguarda, R. "A SPECT study of Parkinsonism in Alzheimer's disease" . Journal of Neuropsychiatry and Clinical Neurosciences 7, no. 3 (1995) : 308-313.http://dx.doi.org/10.1176/jnp.7.3.308
---------- MLA ----------
Starkstein, S.E., Vazquez, S., Merello, M., Teson, A., Petracchi, M., Leiguarda, R. "A SPECT study of Parkinsonism in Alzheimer's disease" . Journal of Neuropsychiatry and Clinical Neurosciences, vol. 7, no. 3, 1995, pp. 308-313.http://dx.doi.org/10.1176/jnp.7.3.308
---------- VANCOUVER ----------
Starkstein, S.E., Vazquez, S., Merello, M., Teson, A., Petracchi, M., Leiguarda, R. A SPECT study of Parkinsonism in Alzheimer's disease. J. NEUROPSYCHIATRY CLIN. NEUROSCI. 1995;7(3):308-313.http://dx.doi.org/10.1176/jnp.7.3.308
