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Vinuesa, A.; Bentivegna, M.; Calfa, G.; Filipello, F.; Pomilio, C.; Bonaventura, M.M.; Lux-Lantos, V.; Matzkin, M.E.; Gregosa, A.; Presa, J.; Matteoli, M.; Beauquis, J.; Saravia, F. "Early Exposure to a High-Fat Diet Impacts on Hippocampal Plasticity: Implication of Microglia-Derived Exosome-like Extracellular Vesicles" (2018) Molecular Neurobiology
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Abstract:

Adolescence is a transitional period from childhood to adulthood characterized by puberty and brain maturation involving behavioral changes and environmental vulnerability. Diet is one of the factors affecting brain health, potentially leading to long-lasting effects. Hence, we studied the impact of early exposure (P21-60) to a high-fat diet (HFD) on mouse hippocampus, analyzing inflammation, adult neurogenesis, dendritic spine plasticity, and spatial memory. Glycemia and seric pro-inflammatory IL1β were higher in HFD mice without differences on body weight. In the HFD hippocampus, neuroinflammation was evidenced by Iba1+ cells reactivity together with a higher expression of TNFα and IL1β while the neurogenic capability in the dentate gyrus was strongly reduced. We found a predominance of immature Dil-labeled dendritic spines from CA1 neurons along with diminished levels of the scaffold protein Shank2, suggesting a defective connectivity. Moreover, the HFD group exhibited spatial memory alterations. To elucidate whether microglia could be mediating HFD-associated neuronal changes, the lipotoxic context was emulated by incubating primary microglia with palmitate, a saturated fatty acid present in HFD. Palmitate induced a pro-inflammatory profile as shown by secreted cytokine levels. The isolated exosome fraction from palmitate-stimulated microglia induced an immature dendritic spine phenotype in primary GFP+ hippocampal neurons, in line with the in vivo findings. These results provide novel data concerning microglia to neuron communication and highlight that fat excess during a short and early period of life could negatively impact on cognition and synaptic plasticity in a neuroinflammatory context, where microglia-derived exosomes could be implicated. [Figure not available: see fulltext.]. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

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Documento: Artículo
Título:Early Exposure to a High-Fat Diet Impacts on Hippocampal Plasticity: Implication of Microglia-Derived Exosome-like Extracellular Vesicles
Autor:Vinuesa, A.; Bentivegna, M.; Calfa, G.; Filipello, F.; Pomilio, C.; Bonaventura, M.M.; Lux-Lantos, V.; Matzkin, M.E.; Gregosa, A.; Presa, J.; Matteoli, M.; Beauquis, J.; Saravia, F.
Filiación:Neurobiology of Aging, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, CABA, Argentina
Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina
IFEC-CONICET, Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina
Laboratory of Pharmacology and Brain Pathology, Humanitas Clinical and Research Center, Milan, Italy
Palabras clave:Adolescence; Dendritic spines; Exosomes; High-fat diet; Hippocampus; Microglia
Año:2018
DOI: http://dx.doi.org/10.1007/s12035-018-1435-8
Título revista:Molecular Neurobiology
Título revista abreviado:Mol. Neurobiol.
ISSN:08937648
CODEN:MONBE
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08937648_v_n_p_Vinuesa

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Citas:

---------- APA ----------
Vinuesa, A., Bentivegna, M., Calfa, G., Filipello, F., Pomilio, C., Bonaventura, M.M., Lux-Lantos, V.,..., Saravia, F. (2018) . Early Exposure to a High-Fat Diet Impacts on Hippocampal Plasticity: Implication of Microglia-Derived Exosome-like Extracellular Vesicles. Molecular Neurobiology.
http://dx.doi.org/10.1007/s12035-018-1435-8
---------- CHICAGO ----------
Vinuesa, A., Bentivegna, M., Calfa, G., Filipello, F., Pomilio, C., Bonaventura, M.M., et al. "Early Exposure to a High-Fat Diet Impacts on Hippocampal Plasticity: Implication of Microglia-Derived Exosome-like Extracellular Vesicles" . Molecular Neurobiology (2018).
http://dx.doi.org/10.1007/s12035-018-1435-8
---------- MLA ----------
Vinuesa, A., Bentivegna, M., Calfa, G., Filipello, F., Pomilio, C., Bonaventura, M.M., et al. "Early Exposure to a High-Fat Diet Impacts on Hippocampal Plasticity: Implication of Microglia-Derived Exosome-like Extracellular Vesicles" . Molecular Neurobiology, 2018.
http://dx.doi.org/10.1007/s12035-018-1435-8
---------- VANCOUVER ----------
Vinuesa, A., Bentivegna, M., Calfa, G., Filipello, F., Pomilio, C., Bonaventura, M.M., et al. Early Exposure to a High-Fat Diet Impacts on Hippocampal Plasticity: Implication of Microglia-Derived Exosome-like Extracellular Vesicles. Mol. Neurobiol. 2018.
http://dx.doi.org/10.1007/s12035-018-1435-8