Zalcman, G.; Federman, N.; Fiszbein, A.; de la Fuente, V.; Ameneiro, L.; Schor, I.; Romano, A. "Sustained CaMKII Delta Gene Expression Is Specifically Required for Long-Lasting Memories in Mice" (2019) Molecular Neurobiology. 56(2):1437-1450
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Although important information is available on the molecular mechanisms of long-term memory formation, little is known about the processes underlying memory persistence in the brain. Here, we report that persistent gene expression of CaMKIIδ isoform participates in object recognition long-lasting memory storage in mice hippocampus. We found that CaMKIIδ mRNA expression was sustained up to one week after training and paralleled memory retention. Antisense DNA infusion in the hippocampus during consolidation or even after consolidation impairs 7-day- but not 1-day-long memory, supporting a role of CaMKIIδ in memory persistence. CaMKIIδ gene expression was accompanied by long-lasting nucleosome occupancy changes at its promoter. This epigenetic mechanism is described for the first time in a memory process and offers a novel mechanism for persistent gene expression in neurons. CaMKIIδ protein is mainly present in nucleus and presynaptic terminals, suggesting a role in these subcellular compartments for memory persistence. All these results point to a key function of the sustained gene expression of this overlooked CaMKII isoform in long-lasting memories. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.


Documento: Artículo
Título:Sustained CaMKII Delta Gene Expression Is Specifically Required for Long-Lasting Memories in Mice
Autor:Zalcman, G.; Federman, N.; Fiszbein, A.; de la Fuente, V.; Ameneiro, L.; Schor, I.; Romano, A.
Filiación:Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Instituto de Fisiología, Biología Molecular y Neurociencias (IFIByNE), UBA-CONICET, Ciudad Universitaria, Buenos Aires, 1428EHA, Argentina
Laboratorio de Circuitos Neuronales, Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)—CONICET—Partner Institute of the Max Planck Society, Godoy Cruz 2390, Buenos Aires, C1425FQD, Argentina
Palabras clave:CaMKII; Hippocampus; Long-term memory; Neuroepigenetics; Nucleosome occupancy
Página de inicio:1437
Página de fin:1450
Título revista:Molecular Neurobiology
Título revista abreviado:Mol. Neurobiol.


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---------- APA ----------
Zalcman, G., Federman, N., Fiszbein, A., de la Fuente, V., Ameneiro, L., Schor, I. & Romano, A. (2019) . Sustained CaMKII Delta Gene Expression Is Specifically Required for Long-Lasting Memories in Mice. Molecular Neurobiology, 56(2), 1437-1450.
---------- CHICAGO ----------
Zalcman, G., Federman, N., Fiszbein, A., de la Fuente, V., Ameneiro, L., Schor, I., et al. "Sustained CaMKII Delta Gene Expression Is Specifically Required for Long-Lasting Memories in Mice" . Molecular Neurobiology 56, no. 2 (2019) : 1437-1450.
---------- MLA ----------
Zalcman, G., Federman, N., Fiszbein, A., de la Fuente, V., Ameneiro, L., Schor, I., et al. "Sustained CaMKII Delta Gene Expression Is Specifically Required for Long-Lasting Memories in Mice" . Molecular Neurobiology, vol. 56, no. 2, 2019, pp. 1437-1450.
---------- VANCOUVER ----------
Zalcman, G., Federman, N., Fiszbein, A., de la Fuente, V., Ameneiro, L., Schor, I., et al. Sustained CaMKII Delta Gene Expression Is Specifically Required for Long-Lasting Memories in Mice. Mol. Neurobiol. 2019;56(2):1437-1450.