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Abstract:

It is well known that, under certain boundary conditions, the retrieval of a stable consolidated memory results into a labile one. During this unstable phase, memory can be vulnerable to interference by a number of pharmacological agents, including benzodiazepines. One of the goals of this study was to evaluate the vulnerability to midazolam (MDZ) after reactivation of recent and remote contextual fear memories in animals that experienced a stressful situation before learning. Animals were subjected to a restraint session and trained in a contextual fear paradigm the following day; consolidated memories were reactivated at different times after learning and different MDZ doses (1.5, 3.0 mg/kg) were administered to rats after reactivation. Our results show that MDZ did not affect memory reconsolidation in older-than-one-day memories of stressed animals, even after the administration of a higher MDZ dose and a longer reactivation session (5 min). In contrast, MDZ was effective in blocking reconsolidation at all memory ages in unstressed animals. In addition, the current research investigated whether activating NMDA sites before reactivation promotes the destabilization of resistant memories such as those of stressed animals. We tested the influence of pre-reactivation D-cycloserine (DCS), a partial NMDA agonist, on MDZ's effect on fear memory reconsolidation in stressed animals. Our findings indicate that DCS before reactivation promotes retrieval-induced lability in resistant memory traces, as MDZ-induced memory impairment in stressed rats became evident with pre-reactivation DCS but not after pre-reactivation sterile isotonic saline. © 2010 Nature Publishing Group All rights reserved.

Registro:

Documento: Artículo
Título:Previous stress Attenuates the Susceptibility to Midazolam's Disruptive Effect on Fear Memory Reconsolidation: Influence of Pre-Reactivation D-Cycloserine Administration
Autor:Bustos, S.G.; Giachero, M.; Maldonado, H.; Molina, V.A.
Filiación:Departamento de Farmacología, Facultad de Ciencias Quý́micas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina
Laboratorio de Neurobiología de la Memoria, Departamento de Fisiologý́a y Biología Molecular, IFIBYNE-CONICET, Buenos Aires, Argentina
Palabras clave:D-cyloserine; Fear memory; Midazolam; Reactivation-reconsolidation; Stress; cycloserine; midazolam; n methyl dextro aspartic acid; sodium chloride; animal experiment; animal model; article; clinical research; controlled study; drug effect; drug sensitivity; fear; information retrieval; learning; male; memory; memory disorder; mental instability; nonhuman; priority journal; rat; stress; training; Animals; Conditioning, Classical; Cycloserine; Dose-Response Relationship, Drug; Fear; GABA Modulators; Male; Memory; Midazolam; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stress, Psychological; Time Factors
Año:2010
Volumen:35
Número:5
Página de inicio:1097
Página de fin:1108
DOI: http://dx.doi.org/10.1038/npp.2009.215
Título revista:Neuropsychopharmacology
Título revista abreviado:Neuropsychopharmacology
ISSN:0893133X
CODEN:NEROE
CAS:cycloserine, 339-72-0, 68-39-3, 68-41-7; midazolam, 59467-70-8; n methyl dextro aspartic acid, 6384-92-5; sodium chloride, 7647-14-5; Cycloserine, 68-41-7; GABA Modulators; Midazolam, 59467-70-8; Neurotransmitter Agents; Receptors, N-Methyl-D-Aspartate
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0893133X_v35_n5_p1097_Bustos

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Citas:

---------- APA ----------
Bustos, S.G., Giachero, M., Maldonado, H. & Molina, V.A. (2010) . Previous stress Attenuates the Susceptibility to Midazolam's Disruptive Effect on Fear Memory Reconsolidation: Influence of Pre-Reactivation D-Cycloserine Administration. Neuropsychopharmacology, 35(5), 1097-1108.
http://dx.doi.org/10.1038/npp.2009.215
---------- CHICAGO ----------
Bustos, S.G., Giachero, M., Maldonado, H., Molina, V.A. "Previous stress Attenuates the Susceptibility to Midazolam's Disruptive Effect on Fear Memory Reconsolidation: Influence of Pre-Reactivation D-Cycloserine Administration" . Neuropsychopharmacology 35, no. 5 (2010) : 1097-1108.
http://dx.doi.org/10.1038/npp.2009.215
---------- MLA ----------
Bustos, S.G., Giachero, M., Maldonado, H., Molina, V.A. "Previous stress Attenuates the Susceptibility to Midazolam's Disruptive Effect on Fear Memory Reconsolidation: Influence of Pre-Reactivation D-Cycloserine Administration" . Neuropsychopharmacology, vol. 35, no. 5, 2010, pp. 1097-1108.
http://dx.doi.org/10.1038/npp.2009.215
---------- VANCOUVER ----------
Bustos, S.G., Giachero, M., Maldonado, H., Molina, V.A. Previous stress Attenuates the Susceptibility to Midazolam's Disruptive Effect on Fear Memory Reconsolidation: Influence of Pre-Reactivation D-Cycloserine Administration. Neuropsychopharmacology. 2010;35(5):1097-1108.
http://dx.doi.org/10.1038/npp.2009.215