Artículo
Sterin-Borda, L.; Gorelik, G.; Genaro, A.; Goin, J.C.; Borda, E.S. "Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction" (1990) FASEB Journal. 4(6):1661-1667
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Abstract:
It is demonstrated that human IgG in Chagas' disease and the corresponding F(ab)'2 fragment attach to lymphoid cells by specific interaction with β-adrenergic and muscarinic cholinergic receptors. This interaction resulted in the transduction of signals that increased intracellular levels of cAMP in enriched T helper cell preparations and cGMP in enriched T suppressor cell preparations. The stimulation of Ts cell muscarinic cholinergic receptors by Chagas IgG or the corresponding F(ab)'2 fraction triggers the release of the immunomodulatory substance PGE2. These results are unified in a theory of immunoregulation and could contribute to the chronic course of Chagas' disease.
Registro:
| Documento: | Artículo |
| Título: | Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction |
| Autor: | Sterin-Borda, L.; Gorelik, G.; Genaro, A.; Goin, J.C.; Borda, E.S. |
| Filiación: | Centro de Estudios Farmacologicos y de Principios Naturales, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Serrano 665, 1414 Buenos Aires, Argentina |
| Palabras clave: | antineurotransmitter IgG; cAMP; cGMP; Chagas' disease; PGE; T helper cell β adrenoreceptor; T suppressor cholinergic receptor; cholinergic receptor; cyclic amp; cyclic gmp; immunoglobulin g; muscarinic receptor; neurotransmitter receptor; prostaglandin e2; radioisotope; article; chagas disease; helper cell; human; human cell; immunoregulation; priority journal; signal transduction; suppressor cell; t lymphocyte; Binding, Competitive; Chagas Disease; Cyclic AMP; Cyclic GMP; Dinoprostone; Human; Immunoglobulin G; Receptors, Adrenergic, beta; Receptors, Muscarinic; Signal Transduction; Support, Non-U.S. Gov't; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Suppressor-Effector |
| Año: | 1990 |
| Volumen: | 4 |
| Número: | 6 |
| Página de inicio: | 1661 |
| Página de fin: | 1667 |
| Título revista: | FASEB Journal |
| Título revista abreviado: | FASEB J. |
| ISSN: | 08926638 |
| CODEN: | FAJOE |
| CAS: | Cyclic AMP, 60-92-4; Cyclic GMP, 7665-99-8; Dinoprostone, 363-24-6; Immunoglobulin G; Receptors, Adrenergic, beta; Receptors, Muscarinic |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08926638_v4_n6_p1661_SterinBorda |
Citas:
---------- APA ----------
Sterin-Borda, L., Gorelik, G., Genaro, A., Goin, J.C. & Borda, E.S. (1990) . Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction. FASEB Journal, 4(6), 1661-1667.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08926638_v4_n6_p1661_SterinBorda [ ]
---------- CHICAGO ----------
Sterin-Borda, L., Gorelik, G., Genaro, A., Goin, J.C., Borda, E.S. "Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction" . FASEB Journal 4, no. 6 (1990) : 1661-1667.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08926638_v4_n6_p1661_SterinBorda [ ]
---------- MLA ----------
Sterin-Borda, L., Gorelik, G., Genaro, A., Goin, J.C., Borda, E.S. "Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction" . FASEB Journal, vol. 4, no. 6, 1990, pp. 1661-1667.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08926638_v4_n6_p1661_SterinBorda [ ]
---------- VANCOUVER ----------
Sterin-Borda, L., Gorelik, G., Genaro, A., Goin, J.C., Borda, E.S. Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction. FASEB J. 1990;4(6):1661-1667.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08926638_v4_n6_p1661_SterinBorda [ ]
