Kornblihtt, A.R.; Pesce, C.G.; Alonso, C.R.; Cramer, P.; Srebrow, A.; Werbajh, S.; Muro, A.F. "The fibronectin gene as a model for splicing and transcription studies" (1996) FASEB Journal. 10(2):248-257
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The fibronectin (FN) gene has become paradigmatic to illustrate genome evolution by exon shuffling, generation of protein diversity by alternative mRNA splicing, and topological coordination between transcription and splicing. Alternative splicing in three sites of the primary transcript gives rise to multiple FN polypeptides. This process is cell type-, development- and age-regulated. The different FN variants seem to play specific roles in FN dimer secretion, blood clotting, adhesion to lymphoid cells, skin wound healing, atherosclerosis, and liver fibrosis. This review focuses on function assignment to the alternatively spliced segments, as well as on the external signals and cis-acting sequences that control the mechanisms of alternative splicing. We also discuss FN transcriptional regulation in response to viral transformation, growth factors, and cyclic AMP in the light of promoter architecture and its interaction with specific transcription factors. The relevance of FN RNA 'tracks' as assembly lines of coordinated transcription and RNA processing is also addressed.


Documento: Artículo
Título:The fibronectin gene as a model for splicing and transcription studies
Autor:Kornblihtt, A.R.; Pesce, C.G.; Alonso, C.R.; Cramer, P.; Srebrow, A.; Werbajh, S.; Muro, A.F.
Filiación:Inst. Invest. Ing. Genet. y Biol. M., Depto. de Ciencias Biológicas, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
INGEBI, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Intl. Ctr. Genetic Eng. B., Padriciano 99, Trieste, Italy
Palabras clave:alternative splicing; cell binding; extra domain I; transcriptional regulation; cyclic amp; fibronectin; growth factor; transcription factor; alternative rna splicing; cell maturation; cell type; down regulation; evolution; exon; genetic transcription; genome; oncogene; priority journal; promoter region; protein structure; review; rna processing; rna sequence; rna splicing; transcription regulation; virus transformation; Alternative Splicing; Animals; Fibronectins; Humans; Oncogenes; Promoter Regions (Genetics); Transcription, Genetic
Página de inicio:248
Página de fin:257
Título revista:FASEB Journal
Título revista abreviado:FASEB J.


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---------- APA ----------
Kornblihtt, A.R., Pesce, C.G., Alonso, C.R., Cramer, P., Srebrow, A., Werbajh, S. & Muro, A.F. (1996) . The fibronectin gene as a model for splicing and transcription studies. FASEB Journal, 10(2), 248-257.
Recuperado de [ ]
---------- CHICAGO ----------
Kornblihtt, A.R., Pesce, C.G., Alonso, C.R., Cramer, P., Srebrow, A., Werbajh, S., et al. "The fibronectin gene as a model for splicing and transcription studies" . FASEB Journal 10, no. 2 (1996) : 248-257.
Recuperado de [ ]
---------- MLA ----------
Kornblihtt, A.R., Pesce, C.G., Alonso, C.R., Cramer, P., Srebrow, A., Werbajh, S., et al. "The fibronectin gene as a model for splicing and transcription studies" . FASEB Journal, vol. 10, no. 2, 1996, pp. 248-257.
Recuperado de [ ]
---------- VANCOUVER ----------
Kornblihtt, A.R., Pesce, C.G., Alonso, C.R., Cramer, P., Srebrow, A., Werbajh, S., et al. The fibronectin gene as a model for splicing and transcription studies. FASEB J. 1996;10(2):248-257.
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