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Most pyrethroid (PYR) insecticides may be classified either as type-I compounds, which produce whole body tremors and hyperthermia, or type-II compounds, which produce salivation, choreoathetosis, and hypothermia (i.e., producing T and CS neurobehavioral syndromes, respectively). This classification is based on clinical observations in adult rats and mice after intracerebroventricular or intravascular administration of highly effective acute (bolus) doses. PYR neurotoxicity in infant animals is not characterized as much as in adult animals. Endpoints informing on vital determinants ofmammal'smaturation, such as body temperature may help recognizing age-related differences in susceptibility to PYRs. In this work, body temperature (Tb) was monitored at 30-min intervals after acute oral exposure to T-syndrome PYR bifenthrin (BIF), CS-syndrome PYR cypermethrin (CYPM), and a BIF?CYPM mixture in weanling rats by using a subcutaneous temperature monitoring system. In both single-compound assays, a time- and dose-related decline of TTb was the most evident impact on thermoregulation observed starting at ~2-3 h after dosing. Moreover, 15-18 mg/kg BIF induced a mild increase in TTb before the hypothermic action was apparent. The lowest effective dose for temperature perturbationwas 15 mg/kg for BIF and 10 mg/kg for CYPM, and moderate neurobehavioral alterations were evident at 12 and 10 mg/kg, respectively. When low effective doses of BIF and CYPM were co-administered mild behavioral effects and a transient increase in TTb (p=0.02) were observed at 1-2 h, and no Tb decline was apparent afterwards compared to control animals. Noteworthy, the hypothermic action of BIF in infant ratswas quite different from the hyperthermia consistently reported in studies usingmature animals. Our results suggest that body temperaturemonitoring may be useful as a complementary assessment to reveal qualitative age-specific pesticide effects in rats. © 2015 Elsevier Inc.


Documento: Artículo
Título:Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats
Autor:Bardullas, U.; Sosa-Holt, C.S.; Pato, A.M.; Nemirovsky, S.I.; Wolansky, M.J.
Filiación:IQUIBICEN Research Institute (CONICET), and School of Exact and Natural Sciences, University of Buenos Aires (UBA), Argentina
Laboratorio QB48, Pabellon 2, Intendente Guiraldes 2160, Ciudad Univ. UBA, Ciudad Autónoma de Buenos Aires, C1428EGA, Argentina
Facultad de Ciencias, Universidad Autónoma de Baja California, Carretera Tijuana-Ensenada, Km 103, Ensenada, Baja California, 22860, Mexico
Palabras clave:Cumulative neurotoxicity; Infancy; Pyrethroids; Thermoregulation; bifenthrin; cypermethrin; bifenthrin; cypermethrin; insecticide; pyrethroid; acoustic evoked startle response; animal experiment; animal model; area under the curve; Article; body temperature; body temperature measurement; chemical structure; concentration response; controlled study; hypothermia; infant; male; maturation; motor activity; neurotoxicity; nonhuman; priority journal; rat; startle reflex; thermoregulation; animal; dose response; drug effects; newborn; oral drug administration; Sprague Dawley rat; thermoregulation; Administration, Oral; Animals; Animals, Newborn; Body Temperature Regulation; Dose-Response Relationship, Drug; Insecticides; Male; Pyrethrins; Rats; Rats, Sprague-Dawley
Página de inicio:1
Página de fin:10
Título revista:Neurotoxicology and Teratology
Título revista abreviado:Neurotoxicol. Teratol.
CAS:bifenthrin, 82657-04-3; cypermethrin, 52315-07-8, 65731-84-2, 66841-24-5, 67375-30-8; bifenthrin; cypermethrin; Insecticides; Pyrethrins


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---------- APA ----------
Bardullas, U., Sosa-Holt, C.S., Pato, A.M., Nemirovsky, S.I. & Wolansky, M.J. (2015) . Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats. Neurotoxicology and Teratology, 52, 1-10.
---------- CHICAGO ----------
Bardullas, U., Sosa-Holt, C.S., Pato, A.M., Nemirovsky, S.I., Wolansky, M.J. "Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats" . Neurotoxicology and Teratology 52 (2015) : 1-10.
---------- MLA ----------
Bardullas, U., Sosa-Holt, C.S., Pato, A.M., Nemirovsky, S.I., Wolansky, M.J. "Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats" . Neurotoxicology and Teratology, vol. 52, 2015, pp. 1-10.
---------- VANCOUVER ----------
Bardullas, U., Sosa-Holt, C.S., Pato, A.M., Nemirovsky, S.I., Wolansky, M.J. Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats. Neurotoxicol. Teratol. 2015;52:1-10.