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Abstract:

Most pyrethroid (PYR) insecticides may be classified either as type-I compounds, which produce whole body tremors and hyperthermia, or type-II compounds, which produce salivation, choreoathetosis, and hypothermia (i.e., producing T and CS neurobehavioral syndromes, respectively). This classification is based on clinical observations in adult rats and mice after intracerebroventricular or intravascular administration of highly effective acute (bolus) doses. PYR neurotoxicity in infant animals is not characterized as much as in adult animals. Endpoints informing on vital determinants ofmammal'smaturation, such as body temperature may help recognizing age-related differences in susceptibility to PYRs. In this work, body temperature (Tb) was monitored at 30-min intervals after acute oral exposure to T-syndrome PYR bifenthrin (BIF), CS-syndrome PYR cypermethrin (CYPM), and a BIF?CYPM mixture in weanling rats by using a subcutaneous temperature monitoring system. In both single-compound assays, a time- and dose-related decline of TTb was the most evident impact on thermoregulation observed starting at ~2-3 h after dosing. Moreover, 15-18 mg/kg BIF induced a mild increase in TTb before the hypothermic action was apparent. The lowest effective dose for temperature perturbationwas 15 mg/kg for BIF and 10 mg/kg for CYPM, and moderate neurobehavioral alterations were evident at 12 and 10 mg/kg, respectively. When low effective doses of BIF and CYPM were co-administered mild behavioral effects and a transient increase in TTb (p=0.02) were observed at 1-2 h, and no Tb decline was apparent afterwards compared to control animals. Noteworthy, the hypothermic action of BIF in infant ratswas quite different from the hyperthermia consistently reported in studies usingmature animals. Our results suggest that body temperaturemonitoring may be useful as a complementary assessment to reveal qualitative age-specific pesticide effects in rats. © 2015 Elsevier Inc.

Registro:

Documento: Artículo
Título:Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats
Autor:Bardullas, U.; Sosa-Holt, C.S.; Pato, A.M.; Nemirovsky, S.I.; Wolansky, M.J.
Filiación:IQUIBICEN Research Institute (CONICET), and School of Exact and Natural Sciences, University of Buenos Aires (UBA), Argentina
Laboratorio QB48, Pabellon 2, Intendente Guiraldes 2160, Ciudad Univ. UBA, Ciudad Autónoma de Buenos Aires, C1428EGA, Argentina
Facultad de Ciencias, Universidad Autónoma de Baja California, Carretera Tijuana-Ensenada, Km 103, Ensenada, Baja California, 22860, Mexico
Palabras clave:Cumulative neurotoxicity; Infancy; Pyrethroids; Thermoregulation; bifenthrin; cypermethrin; bifenthrin; cypermethrin; insecticide; pyrethroid; acoustic evoked startle response; animal experiment; animal model; area under the curve; Article; body temperature; body temperature measurement; chemical structure; concentration response; controlled study; hypothermia; infant; male; maturation; motor activity; neurotoxicity; nonhuman; priority journal; rat; startle reflex; thermoregulation; animal; dose response; drug effects; newborn; oral drug administration; Sprague Dawley rat; thermoregulation; Administration, Oral; Animals; Animals, Newborn; Body Temperature Regulation; Dose-Response Relationship, Drug; Insecticides; Male; Pyrethrins; Rats; Rats, Sprague-Dawley
Año:2015
Volumen:52
Página de inicio:1
Página de fin:10
DOI: http://dx.doi.org/10.1016/j.ntt.2015.09.005
Título revista:Neurotoxicology and Teratology
Título revista abreviado:Neurotoxicol. Teratol.
ISSN:08920362
CODEN:NETEE
CAS:bifenthrin, 82657-04-3; cypermethrin, 52315-07-8, 65731-84-2, 66841-24-5, 67375-30-8; bifenthrin; cypermethrin; Insecticides; Pyrethrins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08920362_v52_n_p1_Bardullas

Referencias:

  • Adolph, E.F., Ontogeny of physiological regulations in the rat (1957) Q. Rev. Biol., 32, pp. 89-137
  • Anand, S.S., Kim, K.-B., Padilla, S., Muralidhara, S., Kim, H.J., Fisher, J.W., Bruckner, J.V., Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity (2006) Drug Metab. Dispos., 34, pp. 389-397
  • Blatteis, C.M., (1998) Physiology and Pathophysiology of Temperature Regulation, , World Scientific Publishing Co. Pte. Ltd., London, UK
  • Blumberg, M.S., Developmental Psychobiology. Chapter 5: The Developmental Context of Thermal Homeostasis (2001) Handbook of Behavioral Neurobiology, 13, pp. 199-228. , Luwer Academic / Plenum Publishers, New York, E. Blass (Ed.)
  • Boyle, J.T., Koldovsky, O., Critical role of adrenal glands in precocious increase in jejunal sucrase activity following premature weaning in rats: negligible effect of food intake (1980) J. Nutr., 110, pp. 169-177
  • Brody, S., Bioenergetics and growth, with special emphasis to efficiency complex in domestic animals. Temperature in life processes (1945) Chapter 11, Homeothermy, Temperature in Life Processes and Productive Efficiency, pp. 264-9694. , Reinhold Publishing Corp., NY, USA
  • Cantalamessa, F., Acute toxicity of two pyrethroids, permethrin and cypermethrin in neonatal and adult rats (1993) Arch. Toxicol., 67 (7), pp. 510-513
  • Casida, J.E., Ueda, K., Gaughan, L.C., Jao, L.T., Soderlund, D.M., Structure-biodegradability relationships in pyrethroid insecticides (1975) Arch. Environ. Contam. Toxicol., 3 (4), pp. 491-500
  • (2003) Toxicological profile for pyrethrins and pyrethroids, , Agency for Toxic Substances and Disease Registry. Center for Disease Control and Prevention, US Department of Health and Human Services
  • (2005) Third National Report on Human Exposure to Environmental Chemicals, , http://www.cdc.gov/exposurereport/3rd/pdf/thirdreport.pdf, Center for Disease Control and Prevention, US Department of Health and Human Services, National Center for Environmental Health
  • Crofton, K.M., Reiter, L.W., Effects of two pyrethroids on motor activity and the acoustic startle response in the rat (1984) Toxicol. Appl. Pharmacol., 75, pp. 318-328
  • Crofton, K.M., Reiter, L.W., The effects of type I and II pyrethroids on motor activity and the acoustic startle response in the rat (1988) Fundam. Appl. Toxicol., 10, pp. 624-634
  • (2011) Background document on RAC opinion on Bifenthrin. Committee on Risk Assessment, RAC, European Chemicals Agency. Annex 1, Background Document # ECHA/RAC/CLH-O-0000001740-81-01/A1, , http://echa.europa.eu/documents/10162/13641/annex_1_bd_bifenthrin_adopted_wrritten_procedure_en.pdf, May 24th
  • Modification of the existing MRLs for cypermethrin in various crops. European Food Safety Authority (2011) EFSA J., 9 (6), p. 2280. , http://www.efsa.europa.eu/en/efsajournal/doc/2280.pdf
  • (2008) Pesticide Residue Monitoring Program 2004-2006, , http://www.cfsan.fda.gov/~dms/pes06rep.html, U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition
  • Fortin, M.C., Bouchard, M., Carrier, G., Dumas, P., Biological monitoring of exposure to pyrethrins and pyrethroids in a metropolitan population of the Province of Quebec, Canada (2008) Environ. Res., 107 (3), pp. 343-350
  • Gammon, D.W., Two classes of pyrethroid action in the cockroach (1981) Pestic. Biochem. Physiol., 15, pp. 181-191
  • Gordon, C.J., Thermal biology of the laboratory rat (1990) Physiol. Behav., 47, pp. 963-991
  • Gordon, C.J., (2005) Temperature and Toxicology: An Integrative, Comparative, and Environmental Approach, , CRC Press, Boca Raton, Florida
  • Gordon, C.J., Spencer, P.J., Hotchkiss, J., Miller, D.B., Hinderliter, P.M., Pauhlun, J., Thermoregulation and its influence in toxicity assessment (2008) Toxicology, 244 (2-3), pp. 87-97
  • Hershey, J.D., Aler, D., Miller, S., Surface temperature correlates to core body temperature in mice across a wide range of values (2014) Lab. Anim. Sci. (LAS Pro), pp. 44-954
  • Heudorf, U., Angerer, J., Drexler, H., Current internal exposure to pesticides in children and adolescents in Germany: urinary levels of metabolites of pyrethroid and organophosphorus insecticides (2004) Int. Arch. Occup. Environ. Health, 77, pp. 67-72
  • Jardim, A.N.O., Caldas, E.D., Brazilian monitoring programs for pesticide residues in food - results from 2001 to 2010 (2012) Food Control, 25 (2), pp. 607-9384
  • Jette, L., Murphy, G.F., Leclerc, J.M., Beliveau, R., Interaction of drugs with P-glycoprotein in brain capillaries (1995) Biochem. Pharmacol., 50, pp. 1701-1709
  • Julien, R., Adamkiewicz, G., Levy, J.I., Bennett, D., Nishioka, M., Spengler, J.D., Pesticide loadings of select organophosphate and pyrethroid pesticides in urban public housing (2007) J. Expo. Sci. Environ. Epidemiol., 18 (2), pp. 167-174
  • Kim, K.B., Anand, S.S., Kim, H.J., White, C.A., Fisher, J.W., Tornero-Velez, R., Bruckner, J.V., Age, dose, and time-dependency of plasma and tissue distribution of deltamethrin in immature rats (2010) Toxicol. Sci., 115 (2), pp. 354-368
  • Kort, W.J., Hekking-Weijma, J.M., TenKate, M.T., Sorm, V., VanStrik, R., A microchip implant system as a method to determine body temperature of terminally ill rats and mice (1998) Lab. Anim, 32 (3), pp. 260-269
  • Krinke, G.J., (2000) The Handbook of Experimental Animals: The Laboratory Rat, , Academic Press, London, G.J. Krinke (Ed.)
  • Kumar, V., Shearer, J.C., Kumar, A., Darsmstadt, G.L., Neonatal hypothermia in low resource settings: a review (2009) J. Perinatol., 29, pp. 401-412
  • Lawrence, L., Casida, J.E., Pyrethroid toxicology: mouse intra-cerebral structure-toxicity relationships (1982) Pestic. Biochem. Physiol., 18, pp. 9-14
  • Leon, M., Development of thermoregulation (1986) Developmental Psychobiology and Developmental Neurobiology. Handbook of Behavioral Neurobiology, pp. 297-9678. , New York, Plenum Press, E.M. Blass (Ed.)
  • Li, H., Ma, H., Lydy, M.J., You, J., Occurrence, seasonal variation and inhalation exposure of atmospheric organophosphate and pyrethroid pesticides in an urban community in South China (2014) Chemosphere, 95, pp. 363-369
  • Mack, M., Gordon, C.J., Differential sensitivity to anticholinesterase insecticides in the juvenile rat: effects on thermoregulation (2007) J. Toxicol. Environ. Health A, 70, pp. 439-444
  • Marshall, S., Gennings, C., Teuschler, L.K., Stork, L.G., Tornero-Velez, R., Crofton, K.M., Rice, G.E., An empirical approach to sufficient similarity: combining exposure data and mixtures toxicology data (2013) Risk Anal., 33 (9), pp. 1582-1595
  • Matsuoka, Y., Okazaki, M., Kitamura, Y., Taniguchi, T., Developmental expression of P-glycoprotein (multidrug resistance gene product) in the rat brain (1999) J. Neurobiol., 39, pp. 383-392
  • McDaniel, K.L., Moser, V.C., Utility of a neurobehavioral screening battery for differentiating the effects of two pyrethroids, permethrin and cypermethrin (1993) Neurotoxicology, 15, pp. 71-83
  • McDaniel, K.L., Moser, V.C., The influence of dosing volume on the toxicity of p,p'-DDT (1997) Neurotoxicology, 18 (4), pp. 1071-1077
  • Melnyk, L.J., Xue, J., Brown, G.G., McCombs, M., Nishioka, M., Michael, L.C., Dietary intakes of pesticides based on community duplicate diet samples (2014) Sci. Total Environ., 468-469, pp. 785-790
  • Miller, M.A., Menowsky, M., Human intravenous injection of β-cyfluthrin with minimal toxic effects: a case report (2014) Am. J. Emerg. Med., 32 (1). , 113.e1-2
  • Morgan, M., Wilsom, N.K., Chuang, J.C., Exposures of 129 preschool children to organochlorines, organophosphates, pyrethroids and acid herbicides at their homes and daycares in North Carolina (2014) Int. J. Environ. Res. Public Health, 11 (4), pp. 3743-3764
  • Mosquera Ortega, M.E., Pato, A.M., Sosa-Holt, C.S., Ridolfi, A., Wolansky, M.J., Villaamil Lepori, E., Relationship between administered dose, target tissue levels and thermoregulatory response alterations after acute oral exposure to the potent tremor-inducing pyrethroid bifenthrin in rats (2013) The Toxicologist, 132 (1), p. 303. , PS1412
  • Narahashi, T., Neuroreceptors and ion channels as the basis for drug action: past, present, and future (2000) J. Pharmacol. Exp. Ther., 294 (1), pp. 1-26
  • Multigenerational reproductive toxicology study of ethynil estradiol in Sprague-Dawley rats (feed studies) (2010) National Toxicology Program, RTP, NC, Technical Report NTP-547, , http://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr547.pdf
  • Patel, M.S., Hiremagalur, B.K., Artificial-rearing technique: its usefulness in nutrition research (1992) J. Nutr., 122, pp. 412-419
  • Pato, A.M., Sosa Holt, C.S., Wolansky, M.J., Time, dose, and structure dependent actions of pyrethroid insecticides on rat thermoregulation (2011) The Toxicologist, 120 (2), p. 288. , PS1346
  • Pauluhn, J., LH Machemer assessment of pyrethroid-induced paraesthesias: comparison of animal model and human data (1998) Toxicol. Lett., 96-97, pp. 361-368
  • Pine, A.P., Jessop, N.S., Oldham, J.D., Maternal protein reserves and their influence on lactational performance in rats. 3. The effects of dietary protein restriction and stage of lactation on milk composition (1994) Br. J. Nutr., 72, pp. 815-9170
  • Rich, K.J., Boobis, A.R., Expression and inducibility of P450 enzymes during liver ontogeny (1997) Microsc. Res. Tech., 39 (5), pp. 424-435
  • Roberts, J.R., Karr, C.J., Health Pesticide exposure in children (2012) Pediatrics, 130 (6), pp. e1765-e1788. , (Erratum in: Pediatrics 131(5) (2013) 1013-1014)
  • Scollon, E.J., Starr, J.M., Crofton, K.M., Wolansky, M.J., DeVito, M.J., Hughes, M.F., Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat (2011) Toxicology, 290 (1), pp. 1-6
  • Shafer, T.J., Meyer, D.A., Crofton, K.M., Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs (2005) Environ. Health Perspect., 113, pp. 123-136
  • Sheets, L.P., A consideration of age-dependent differences in susceptibility to organophosphorus and pyrethroid insecticides (2000) Neurotoxicology, 21 (1-2), pp. 57-63
  • Sheets, L.P., Doherty, J.D., Law, M.W., Reiter, L.W., Crofton, K.M., Age-dependent differences in the susceptibility of rats to deltamethrin (1994) Toxicol. Appl. Pharmacol., 126 (1), pp. 186-190
  • Soderlund, D.M., Clark, J.M., Sheets, L.P., Mullin, L.S., Picirillo, V.J., Sargent, D., Stevens, J.T., Weiner, M.L., Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment (2002) Toxicology, 171, pp. 3-59
  • Starr, J., Scollon, E.J., Hughes, M.F., Ross, D.G., Graham, S.E., Crofton, K.M., Wolansky, M.J., Tornero-Velez, R., Environmentally relevant mixtures in cumulative assessments: an acute study of toxicokinetics and effects on motor activity in rats exposed to a mixture of pyrethroids (2012) Toxicol. Sci., 130 (2), pp. 309-318
  • Tornero-Velez, R., Mirfazaelian, A., Kim, K.B., Anand, S.S., Kim, H.J., Haines, W.T., Bruckner, J.V., Fisher, J.W., Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model (2010) Toxicol. Appl. Pharmacol., 244 (2), pp. 208-217
  • Tornero-Velez, R., Egeghy, P.P., Cohen Hubal, E.A., Biogeographical analysis of chemical co-occurrence data to identify priorities for mixtures research (2012) Risk Anal., 32 (2), pp. 224-236
  • Tulve, N.S., Jones, P.A., Nishioka, M.G., Fortmann, R.C., Croghan, C.W., Zhou, J.Y., Fraser, A., Friedman, W., Pesticide measurements from the First National Environmental Health Survey of child care centers using a multi-residue GC/MS analysis method (2006) Environ. Sci. Technol., 40 (20), pp. 6269-6274
  • Verschoyle, R.D., Aldridge, W.N., Structure-activity relationships of some pyrethroids in rats (1980) Arch. Toxicol., 45, pp. 325-329
  • Vlach, K.D., Boles, J.W., Stiles, B.G., Telemetric evaluation of body temperature and physical activity as predictors of mortality in a murine model of staphylococcal enterotoxic shock (2000) Comp. Med., pp. 160-166
  • Weston, D.P., Ramil, H.L., Lydy, M.J., Pyrethroid insecticides in municipal wastewater (2013) Environ. Toxicol. Chem., 32, pp. 2460-2468
  • The WHO recommended classification of pesticides by hazard (2010) Guidelines to Classification 2009. International Programme on Chemical Safety, , http://www.who.int/ipcs/publications/pesticides_hazard_2009.pdf?ua=1, World Health Organization, Geneve
  • Williams, M.T., Herring, N.R., Schaefer, T.L., Skelton, M.R., Campbell, N.G., Lipton, J.W., McCrea, A.E., Vorhees, C.V., Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine ('foxy') to adult rats: a new drug of abuse (2007) Neuropsychopharmacology, 32 (6), pp. 1404-1420
  • Wolansky, M.J., Harrill, J.A., Neurobehavioral toxicology of pyrethroid insecticides in adult animals: a critical review (2008) Neurotoxicol. Teratol., 30 (2), pp. 55-78
  • Wolansky, M.J., Tornero-Velez, R., Animal data sufficiency in risk assessment. Consideration of the multiplicity of experimental and organismic determinants of pyrethroid neurotoxicity: a proof of concept (2013) J. Toxicol. Environ. Health Part B (Crit. Rev.), 16 (8), pp. 453-490
  • Wolansky, M.J., Gennings, C., Crofton, K.M., Relative potencies for acute effects of pyrethroids on motor function in rats (2006) Toxicol. Sci., 89 (1), pp. 271-277
  • Wolansky, M.J., McDaniel, K.L., Moser, V.C., Crofton, K.M., Influence of dosing volume on the neurotoxicity of bifenthrin (2007) Neurotoxicol. Teratol., 29, pp. 377-384
  • Wolansky, M.J., Mack, C.M., Becker, P.B., Gordon, C.J., Crofton, K.M., Effects of acute pyrethroid exposure on thermoregulation in rats (2007) The Toxicologist, 91 (1), p. 186. , PS423
  • Wolansky, M.J., Gennings, C., DeVito, M.J., Crofton, K.M., Evidence for dose additive effects of pyrethroids on motor activity in rats (2009) Environ. Health Perspect., 117, pp. 1563-1570
  • Wood, A., Alan Wood's compendium of pesticide common names: classified lists of pesticides, , http://www.alanwood.net/pesticides/class_pesticides.html

Citas:

---------- APA ----------
Bardullas, U., Sosa-Holt, C.S., Pato, A.M., Nemirovsky, S.I. & Wolansky, M.J. (2015) . Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats. Neurotoxicology and Teratology, 52, 1-10.
http://dx.doi.org/10.1016/j.ntt.2015.09.005
---------- CHICAGO ----------
Bardullas, U., Sosa-Holt, C.S., Pato, A.M., Nemirovsky, S.I., Wolansky, M.J. "Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats" . Neurotoxicology and Teratology 52 (2015) : 1-10.
http://dx.doi.org/10.1016/j.ntt.2015.09.005
---------- MLA ----------
Bardullas, U., Sosa-Holt, C.S., Pato, A.M., Nemirovsky, S.I., Wolansky, M.J. "Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats" . Neurotoxicology and Teratology, vol. 52, 2015, pp. 1-10.
http://dx.doi.org/10.1016/j.ntt.2015.09.005
---------- VANCOUVER ----------
Bardullas, U., Sosa-Holt, C.S., Pato, A.M., Nemirovsky, S.I., Wolansky, M.J. Evidence for effects on thermoregulation after acute oral exposure to type I and type II pyrethroids in infant rats. Neurotoxicol. Teratol. 2015;52:1-10.
http://dx.doi.org/10.1016/j.ntt.2015.09.005