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Up to 35% of pregnant women take psychotropic drugs at least once during gestation [Austin and Mitchell, 1998]. From concurrent animal and human evidence, it has been proposed that exposure to several psychoactive medications in utero or during lactation increases the risk for permanent brain disorders. Present preventive or therapy practices applied on humans for this type of long-lasting behavioral alterations are mainly based on empirical results. Here, we test an experimental approach designed to counteract a circling performance deficit that appears in Sprague-Dawley rats at puberty on exposure to the dopaminergic blocker haloperidol (HAL) during gestation [J.L. Brusés, J.M. Azcurra, The circling training: A behavioral paradigm for functional teratology testing, in: P.M. Conn (Ed.), Paradigms for the study of behavior, Acad. Press, New York, 1993, pp. 166-179. Method Neurosci. 14]. Gestational exposure to HAL (GD 5-18, 2.5 mg/kg/day ip) induced the expected circling activity decrease in the offspring at the fifth week of life. When prenatal exposure to HAL was continued through lactation (PD5-21, 1.5 mg/kg/day ip), rats otherwise showed a control-like circling performance. No difference was yet found between lactation-only, HAL-exposed pups and saline (SAL)-treated controls (n=8 each group). We further performed saturating (3H)-spiroperidol (SPI) binding assays on striatal P2 membrane fractions 2 months later. The dopamine-type D2-specific binding results suggested that above circling behavior findings could be partially explained by enduring HAL-induced neurochemical changes. The role of critical periods of sensitivity as transient windows for opportunistic therapies for behavioral teratology is discussed. © 2004 Elsevier Inc. All rights reserved.


Documento: Artículo
Título:Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug
Autor:Wolansky, M.J.; Soiza-Reilly, M.; Fossati, M.; Azcurra, J.M.
Filiación:Interdisc. Proj. on Neuroteratology, Depto. de Biodiversidad Y Biol. Exp., Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina
C. F. Melo 4127 (C.P. 1602), Buenos Aires, Argentina
Neurotoxicology Division, Natl. Hlth. Environ. Effects Res. L., US EPA, Research Triangle Park, NC 27711, United States
Palabras clave:Behavioral teratogen; Haloperidol; Therapeutic agent; haloperidol; animal experiment; animal model; animal tissue; article; behavior disorder; behavior teratology; circling behavior; controlled study; female; lactation; nonhuman; perinatal drug exposure; prenatal drug exposure; priority journal; progeny; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Brain; Dopamine Antagonists; Female; Haloperidol; Male; Pregnancy; Prenatal Exposure Delayed Effects; Radioligand Assay; Random Allocation; Rats; Rats, Sprague-Dawley; Spiperone; Stereotyped Behavior; Stereotypic Movement Disorder; Tritium; Animalia
Página de inicio:561
Página de fin:569
Título revista:Neurotoxicology and Teratology
Título revista abreviado:Neurotoxicol. Teratol.
CAS:haloperidol, 52-86-8; Dopamine Antagonists; Haloperidol, 52-86-8; Spiperone, 749-02-0; Tritium, 10028-17-8


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---------- APA ----------
Wolansky, M.J., Soiza-Reilly, M., Fossati, M. & Azcurra, J.M. (2004) . Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug. Neurotoxicology and Teratology, 26(4), 561-569.
---------- CHICAGO ----------
Wolansky, M.J., Soiza-Reilly, M., Fossati, M., Azcurra, J.M. "Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug" . Neurotoxicology and Teratology 26, no. 4 (2004) : 561-569.
---------- MLA ----------
Wolansky, M.J., Soiza-Reilly, M., Fossati, M., Azcurra, J.M. "Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug" . Neurotoxicology and Teratology, vol. 26, no. 4, 2004, pp. 561-569.
---------- VANCOUVER ----------
Wolansky, M.J., Soiza-Reilly, M., Fossati, M., Azcurra, J.M. Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug. Neurotoxicol. Teratol. 2004;26(4):561-569.