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Abstract:

Balb/c mice were immunized with homologous heart in complete Freund's adjuvant to induce autoimmune myocarditis. The myocarditis was characterized by lymphomononuclear infiltration, electrocardiographic abnormalities and antimuscle antibodies by indirect immunofluorescence. In this paper, we demonstrate that the IgG present in autoimmune myocarditis mice is able to bind to βadrenoreceptors of the heart and also induce a biological effect inhibiting the contractile action of exogenous norepinephrine. Auto-immune IgG inhibited the binding of (3H)-dyhidroalprenolol to a βadrenergic receptor of purified myocardial membranes behaving as non-competitive inhibitor. This IgG also exerted a non-competitive inhibition upon the mechanical effect of exogenous norepinephrine. The recognition appears to be organ specific, because the autoimmune myocarditis IgG did not bind to βlymphocyte, lung and fat adrenoreceptors. The autoimmune IgG inhibited the stimulatory action of isoproterenol on cAMP levels, behaving as a βadrenergic antagonist. © 1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Registro:

Documento: Artículo
Título:βadrenergic cardiac antibody in autoimmune myocarditis
Autor:Leiros, C.P.; And, L.S.-B.; Borda, E.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigations Cientificas y Técnicas (CONICET), Serrano 665, (1414), Buenos Aires, Argentina
Palabras clave:Anti βadrenergic; Antibodies; Autoimmunity; Cardiac contractility; Myocarditis; Receptor antibody; βadrenergic receptors; autoantibody; beta adrenergic receptor; dihydroalprenolol; propranolol; receptor antibody; animal cell; animal experiment; autoimmunity; heart muscle contractility; mouse; myocarditis; nonhuman; Animal; Autoantibodies; Autoimmune Diseases; Binding, Competitive; Cyclic AMP; Dihydroalprenolol; Immunoglobulin G; In Vitro; Male; Mice; Mice, Inbred BALB C; Myocardial Contraction; Myocarditis; Myocardium; Organ Specificity; Receptors, Adrenergic, beta; Support, Non-U.S. Gov't
Año:1989
Volumen:2
Número:3
Página de inicio:223
Página de fin:234
DOI: http://dx.doi.org/10.3109/08916938909014686
Título revista:Autoimmunity
Título revista abreviado:Autoimmunity
ISSN:08916934
CODEN:AUIME
CAS:dihydroalprenolol, 60106-89-0; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; Autoantibodies; Cyclic AMP, 60-92-4; Dihydroalprenolol, 60106-89-0; Immunoglobulin G; Receptors, Adrenergic, beta
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08916934_v2_n3_p223_Leiros

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Citas:

---------- APA ----------
Leiros, C.P., And, L.S.-B. & Borda, E. (1989) . βadrenergic cardiac antibody in autoimmune myocarditis. Autoimmunity, 2(3), 223-234.
http://dx.doi.org/10.3109/08916938909014686
---------- CHICAGO ----------
Leiros, C.P., And, L.S.-B., Borda, E. "βadrenergic cardiac antibody in autoimmune myocarditis" . Autoimmunity 2, no. 3 (1989) : 223-234.
http://dx.doi.org/10.3109/08916938909014686
---------- MLA ----------
Leiros, C.P., And, L.S.-B., Borda, E. "βadrenergic cardiac antibody in autoimmune myocarditis" . Autoimmunity, vol. 2, no. 3, 1989, pp. 223-234.
http://dx.doi.org/10.3109/08916938909014686
---------- VANCOUVER ----------
Leiros, C.P., And, L.S.-B., Borda, E. βadrenergic cardiac antibody in autoimmune myocarditis. Autoimmunity. 1989;2(3):223-234.
http://dx.doi.org/10.3109/08916938909014686