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Abstract:

The aim of this work was to assess the effect of metronidazole (MTZ) on the stages of the seminiferous epithelial cycle and spermatozoa morphology when the drug is administered in human therapeutic doses to 60-day-old CFW male mice. The frequency of the stages was established by counting spermatocytes in pachytene and spermatids. Abnormalities in the flagellum or the head, lack of maturity and multiple malformations, were considered in the morphological analysis. Murine control strain was compared with MTZ treated group (v.ip 130 mg/kg/bw) both kept in standard captivity conditions. Cellular composition or number of stages in the seminiferous tubules were not altered in MTZ exposed animals, though the number of cells in stages I, V and XII was increased. The sperm cell morphology was severely affected by the treatment with potentially serious consequences on the normal fertilization process. Thus, the MTZ has to be considered as a conceivable thread regarding male fertility. © 2006 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Metronidazole-induced alterations in murine spermatozoa morphology
Autor:Mudry, M.D.; Palermo, A.M.; Merani, M.S.; Carballo, M.A.
Filiación:GIBE (Grupo de Investigación en Biología Evolutiva), Departamento Ecología, Genética y Evolución, Facultad de Ciencias Exactas y Naturales (FCEyN), Argentina
CITEFA (Instituto de Investigaciones Cientificas y Tecnicas de las FFAA), Villa Martelli, Buenos Aires, Argentina
CIR (Centro de Investigaciones en Reproducción), Departamento Histología, Embriología y Genética, Facultad de Medicina, Universidad de Buenos Aires, Argentina
CIGETOX (Centro de Investigaciones en Genética Toxicológica), Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
Idioma: Inglés
Palabras clave:CFW male mice; Human therapeutic dose; Metronidazole (MTZ); Seminiferous epithelium cycle; Spermatozoa morphology; metronidazole; animal cell; animal experiment; animal model; article; cell count; cell cycle; cell maturation; cell structure; controlled study; epithelium cell; fertilization; male; male fertility; morphological trait; mouse; multiple malformation syndrome; nonhuman; pachytene; seminiferous tubule epithelium; spermatozoon; spermatozoon tail; Animals; Antiprotozoal Agents; Cell Count; Fertility; Male; Metronidazole; Mice; Mice, Inbred Strains; Pachytene Stage; Seminiferous Tubules; Spermatids; Spermatozoa; Animalia; Murinae; Mus
Año:2007
Volumen:23
Número:2
Página de inicio:246
Página de fin:252
DOI: http://dx.doi.org/10.1016/j.reprotox.2006.11.010
Título revista:Reproductive Toxicology
Título revista abreviado:Reprod. Toxicol.
ISSN:08906238
CODEN:REPTE
CAS:metronidazole, 39322-38-8, 443-48-1; Antiprotozoal Agents; Metronidazole, 443-48-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08906238_v23_n2_p246_Mudry

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Citas:

---------- APA ----------
Mudry, M.D., Palermo, A.M., Merani, M.S. & Carballo, M.A. (2007) . Metronidazole-induced alterations in murine spermatozoa morphology. Reproductive Toxicology, 23(2), 246-252.
http://dx.doi.org/10.1016/j.reprotox.2006.11.010
---------- CHICAGO ----------
Mudry, M.D., Palermo, A.M., Merani, M.S., Carballo, M.A. "Metronidazole-induced alterations in murine spermatozoa morphology" . Reproductive Toxicology 23, no. 2 (2007) : 246-252.
http://dx.doi.org/10.1016/j.reprotox.2006.11.010
---------- MLA ----------
Mudry, M.D., Palermo, A.M., Merani, M.S., Carballo, M.A. "Metronidazole-induced alterations in murine spermatozoa morphology" . Reproductive Toxicology, vol. 23, no. 2, 2007, pp. 246-252.
http://dx.doi.org/10.1016/j.reprotox.2006.11.010
---------- VANCOUVER ----------
Mudry, M.D., Palermo, A.M., Merani, M.S., Carballo, M.A. Metronidazole-induced alterations in murine spermatozoa morphology. Reprod. Toxicol. 2007;23(2):246-252.
http://dx.doi.org/10.1016/j.reprotox.2006.11.010