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Abstract:

TGF-β1 is an anti-inflammatory cytokine that is augmented in the brain of autistic patients and that can affect brain development. In this work, we studied the effects of overexpressing TGF-β1 in the dentate gyrus of adult or young mice on behavior. TGF-β1 overexpression during postnatal development led to a long-term decrease in social interaction and to long-term increases in self-grooming and depression-related behaviors. Our analysis shows that these behavioral changes correlate with the long-term downregulation of TGF-β1 and IL-6 expression in the dentate gyrus, as well as to decreases in the mRNA levels of the synaptic protein neuroligin 3 and in the number of Reelin-positive neurons in the dentate gyrus. In contrast, chronic expression of TGF-β1 during adulthood led to transient opposite effects on these behaviors. These results show a central role of hippocampal TGF-β1 in the programming and modulation of social interaction, repetitive behavior and depression-related behavior. Finally, our data suggest a role of hippocampal TGF-β1 and early-life neuroinflammation in the development of the behavioral alterations observed in autism spectrum disorders. © 2011 Elsevier Inc.

Registro:

Documento: Artículo
Título:Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior
Autor:Depino, A.M.; Lucchina, L.; Pitossi, F.
Filiación:Institute for Physiology, Molecular Biology and Neurosciences, CONICET-UBA, C1428EHA Buenos Aires, Argentina
Department of Physiology, Molecular and Cellular Biology, FCEyN, University of Buenos Aires, C1428EHA Buenos Aires, Argentina
Leloir Institute Foundation, Institute for Biochemical Investigations, CONICET, 1405 Buenos Aires, Argentina
Palabras clave:Autism; Behavior; Mice; Neuroinflammation; Postnatal programming; Transforming Growth Factor-beta 1; interleukin 6; neuroligin; reelin; transforming growth factor beta1; animal experiment; article; behavior; compulsion; controlled study; dentate gyrus; depression; gene overexpression; grooming; hippocampus; male; mouse; nerve cell; nonhuman; priority journal; protein expression; social interaction; Adenoviridae; Animals; Behavior, Animal; Depression; Female; Gliosis; Grooming; Hindlimb Suspension; Hippocampus; Immunohistochemistry; Interpersonal Relations; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pregnancy; Real-Time Polymerase Chain Reaction; RNA, Messenger; Stereotaxic Techniques; Swimming; Transforming Growth Factor beta1
Año:2011
Volumen:25
Número:8
Página de inicio:1582
Página de fin:1591
DOI: http://dx.doi.org/10.1016/j.bbi.2011.05.007
Título revista:Brain, Behavior, and Immunity
Título revista abreviado:Brain Behav. Immun.
ISSN:08891591
CODEN:BBIME
CAS:RNA, Messenger; Transforming Growth Factor beta1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08891591_v25_n8_p1582_Depino

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Citas:

---------- APA ----------
Depino, A.M., Lucchina, L. & Pitossi, F. (2011) . Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior. Brain, Behavior, and Immunity, 25(8), 1582-1591.
http://dx.doi.org/10.1016/j.bbi.2011.05.007
---------- CHICAGO ----------
Depino, A.M., Lucchina, L., Pitossi, F. "Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior" . Brain, Behavior, and Immunity 25, no. 8 (2011) : 1582-1591.
http://dx.doi.org/10.1016/j.bbi.2011.05.007
---------- MLA ----------
Depino, A.M., Lucchina, L., Pitossi, F. "Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior" . Brain, Behavior, and Immunity, vol. 25, no. 8, 2011, pp. 1582-1591.
http://dx.doi.org/10.1016/j.bbi.2011.05.007
---------- VANCOUVER ----------
Depino, A.M., Lucchina, L., Pitossi, F. Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior. Brain Behav. Immun. 2011;25(8):1582-1591.
http://dx.doi.org/10.1016/j.bbi.2011.05.007