Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Chronic stress and depression are widely known to down-regulate the immune system, and several antidepressants can reverse this impairment, with or without effects in normal subjects. Although the central nervous system is undoubtedly involved in these events, some psychotropic drugs can also exert direct effects on lymphoid cells. We have recently shown that the antidepressant fluoxetine enhances T cell proliferation and TH1 cytokine production in vivo, without changes on CD4/CD8 subsets. In vitro, a direct action of fluoxetine upon T lymphocyte reactivity by complex mechanisms was also described. In another work, we also found that chronic stress reduces T cell mediated immunity, namely a decrease of T cell response to mitogens, TH1 cytokine production and CD4+-but not CD8+-T lymphocytes. Here we investigated the effects of fluoxetine on chronic stress-driven immune system depression. We found that fluoxetine restored T cell proliferation and interleukin-2, interferon-γ and tumor necrosis factor-α production by compensatory mechanisms. In addition, CD4/CD8 ratio was also normalized by antidepressant administration, but this seems to be a non-compensatory effect associated specifically to stress. No changes were observed in other lymphoid cells, i.e. natural killer cells and B lymphocytes. Finally, we observed that fluoxetine is able to reverse T cell reactivity impairment in vitro by a direct action at clinically relevant doses. These results highlight the relevance of pharmacological treatment of stress and depression, and may help to begin elucidating the complex events triggered-directly and/or indirectly-by antidepressants in non-neuronal cell types. © 2008 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Fluoxetine directly counteracts the adverse effects of chronic stress on T cell immunity by compensatory and specific mechanisms
Autor:Frick, L.R.; Rapanelli, M.; Cremaschi, G.A.; Genaro, A.M.
Filiación:Centro de Estudios Farmacológicos y Botánicos, Consejo Nacional de Investigaciones Científicas y Técnicas, Cátedra de Farmacología, Paraguay 2155, Buenos Aires 1121, Argentina
Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, Buenos Aires, 1428, Argentina
Palabras clave:Antidepressant; B cells; CD4/CD8; Chronic stress; Cytokines; Depression; Fluoxetine; Natural killer; T cells; concanavalin A; fluoxetine; gamma interferon; interleukin 2; tumor necrosis factor alpha; animal cell; animal experiment; animal model; animal tissue; article; CD4 CD8 ratio; cell proliferation; cellular immunity; chronic stress; controlled study; depression; drug mechanism; female; in vitro study; nonhuman; priority journal; T lymphocyte; Animals; Antidepressive Agents, Second-Generation; B-Lymphocytes; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Chronic Disease; Female; Flow Cytometry; Fluoxetine; Interferon-gamma; Interleukin-2; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Restraint, Physical; Reverse Transcriptase Polymerase Chain Reaction; Stress, Psychological; T-Lymphocytes; Tumor Necrosis Factor-alpha
Año:2009
Volumen:23
Número:1
Página de inicio:36
Página de fin:40
DOI: http://dx.doi.org/10.1016/j.bbi.2008.06.010
Título revista:Brain, Behavior, and Immunity
Título revista abreviado:Brain Behav. Immun.
ISSN:08891591
CODEN:BBIME
CAS:concanavalin A, 11028-71-0; fluoxetine, 54910-89-3, 56296-78-7, 59333-67-4; gamma interferon, 82115-62-6; interleukin 2, 85898-30-2; Antidepressive Agents, Second-Generation; Fluoxetine, 54910-89-3; Interferon-gamma, 82115-62-6; Interleukin-2; Tumor Necrosis Factor-alpha
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08891591_v23_n1_p36_Frick

Referencias:

  • Alfonso, J., Frick, L.R., Silberman, D.M., Palumbo, M.L., Genaro, A.M., Frasch, A.C., Regulation of hippocampal gene expression is conserved in two species subjected to different stressors and antidepressant treatments (2006) Biol. Psychiatry, 59, pp. 244-251
  • Battaglino, R., Vokes, M., Schulze-Späte, U., Sharma, A., Graves, D., Kohler, T., Müller, R., Stashenko, P., Fluoxetine treatment increases trabecular bone formation in mice (2007) J. Cell. Biochem., 100, pp. 1387-1394
  • Calcagni, E., Elenkov, I., Stress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases (2006) Ann. NY Acad. Sci., 1069, pp. 62-76
  • Dulawa, S.C., Holick, K.A., Gundersen, B., Hen, R., Effects of chronic fluoxetine in animal models of anxiety and depression (2004) Neuropsychopharmacology, 29, pp. 1321-1330
  • Edgar, V.A., Cremaschi, G.A., Sterin-Borda, L., Genaro, A.M., Altered expression of autonomic neurotransmitter receptors and proliferative responses in lymphocytes from a chronic mild stress model of depression: effects of fluoxetine (2002) Brain Behav. Immun., 16, pp. 333-350
  • Edgar, V.A., Genaro, A.M., Cremaschi, G., Sterin-Borda, L., Fluoxetine action on murine T-lymphocyte proliferation: participation of PKC activation and calcium mobilisation (1998) Cell Signal., 10, pp. 721-726
  • Edgar, V.A., Sterin-Borda, L., Cremaschi, G.A., Genaro, A.M., Role of protein kinase C and cAMP in fluoxetine effects on human T-cell proliferation (1999) Eur. J. Pharmacol., 372, pp. 65-73
  • Frick, L.R., Barreiro Arcos, M.L., Rapanelli, M., Zappia, M.P., Brocco, M., Mongini, C., Genaro, A.M., Cremaschi, G.A., Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice (2008) Stress, , 10.1080/10253890802137437
  • Frick, L.R., Palumbo, M.L., Zappia, M.P., Brocco, M.A., Cremaschi, G.A., Genaro, A.M., Inhibitory effect of fluoxetine on lymphoma growth through the modulation of antitumor T cell response by serotonin dependent and independent mechanisms (2008) Biochem. Pharmacol., 75, pp. 1817-1826
  • Glaser, R., Kiecolt-Glaser, J.K., Stress-induced immune dysfunction: implications for health (2005) Nat. Rev. Immunol., 5, pp. 243-251
  • Gordon, J., Barnes, N.M., Lymphocytes transport serotonin and dopamine: agony or ecstasy (2003) Trends Immunol., 24, pp. 438-443
  • Koran, L.M., Cain, J.W., Dominguez, R.A., Rush, A.J., Thiemann, S., Are fluoxetine plasma levels related to outcome in obsessive-compulsive disorder? (1996) Am. J. Psychiatry, 153, pp. 1450-1454
  • Pacher, P., Ungvari, Z., Kecskeméti, V., Friedmann, T., Furst, S., Serotonin reuptake inhibitors fluoxetine and citalopram relax intestinal smooth muscle (2001) Can. J. Physiol. Pharmacol., 79, pp. 580-584
  • Pellegrino, T.C., Bayer, B.M., Modulation of immune cell function following fluoxetine administration in rats (1998) Pharmacol. Biochem. Behav., 59, pp. 151-157
  • Pellegrino, T.C., Bayer, B.M., Role of central 5-HT(2) receptors in fluoxetine-induced decreases in T lymphocyte activity (2002) Brain Behav. Immun., 16, pp. 87-103
  • Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Hen, R., Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants (2003) Science, 301, pp. 805-809
  • Serafeim, A., Gordon, J., The immune system gets nervous (2001) Curr. Opin. Pharmacol., 1, pp. 398-403
  • Willner, P., Mitchell, P.J., The validity of animal models of predisposition to depression (2002) Behav. Pharmacol., 13, pp. 169-188
  • Wunderlich, J., Shearer, G., Livingstone, A., Induction and measurement of cytotoxic T lymphocyte activity (1997) Current Protocols in Immunology, , Coligan J.E., Kruisbeek A., Margulies D., Shevach E., and Strober W. (Eds), John Wiley and Sons, Inc., New York pp. 3.11.1-3.11.20

Citas:

---------- APA ----------
Frick, L.R., Rapanelli, M., Cremaschi, G.A. & Genaro, A.M. (2009) . Fluoxetine directly counteracts the adverse effects of chronic stress on T cell immunity by compensatory and specific mechanisms. Brain, Behavior, and Immunity, 23(1), 36-40.
http://dx.doi.org/10.1016/j.bbi.2008.06.010
---------- CHICAGO ----------
Frick, L.R., Rapanelli, M., Cremaschi, G.A., Genaro, A.M. "Fluoxetine directly counteracts the adverse effects of chronic stress on T cell immunity by compensatory and specific mechanisms" . Brain, Behavior, and Immunity 23, no. 1 (2009) : 36-40.
http://dx.doi.org/10.1016/j.bbi.2008.06.010
---------- MLA ----------
Frick, L.R., Rapanelli, M., Cremaschi, G.A., Genaro, A.M. "Fluoxetine directly counteracts the adverse effects of chronic stress on T cell immunity by compensatory and specific mechanisms" . Brain, Behavior, and Immunity, vol. 23, no. 1, 2009, pp. 36-40.
http://dx.doi.org/10.1016/j.bbi.2008.06.010
---------- VANCOUVER ----------
Frick, L.R., Rapanelli, M., Cremaschi, G.A., Genaro, A.M. Fluoxetine directly counteracts the adverse effects of chronic stress on T cell immunity by compensatory and specific mechanisms. Brain Behav. Immun. 2009;23(1):36-40.
http://dx.doi.org/10.1016/j.bbi.2008.06.010