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Abstract:

Immune evasion strategies are important for the onset and the maintenance of viral infections. Many viruses have evolved mechanisms to counteract or suppress the host immune response. We have previously characterized two syncytial (syn) variants of Herpes simplex 1 (HSV-1) strain F, syn14-1 and syn17-2, obtained by selective pressure with a natural carrageenan. These variants showed a differential pathology in vaginal and respiratory mucosa infection in comparison with parental strain. In this paper, we evaluated the modulation of immune response in respiratory mucosa by these HSV-1 variants. We observed altered levels of Tumor Necrosis Factor-α and Interleukin-6 in lungs of animals infected with the syn14-1 and syn17-2 variants compared with the parental strain. Also, we detected differences in the recruitment of immune cells to the lung in syn variants infected mice. Both variants exhibit one point mutation in the sequence of the gene of glycoprotein D detected in the ectodomain of syn14-1 and the cytoplasmic tail of syn17-2. Results obtained in the present study contribute to the characterization of HSV-1 syn variants and the participation of the cellular inflammatory response in viral pathogenesis. © 2014 Elsevier Ltd.

Registro:

Documento: Artículo
Título:Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1
Autor:Carolina Artuso, M.; Linero, F.N.; Gazzaniga, S.; Scolaro, L.A.; Pujol, C.A.; Wainstok, R.; Carlucci, M.J.
Filiación:Laboratorio de Virología - Departamento de Química Biológica, Pab.2, Piso 4. Ciudad Universitaria, 1428EGA Buenos Aires, Argentina
Laboratorio de Biología Tumoral - Departamento de Química Biológica, Pab.2, Piso 4. Ciudad Universitaria, 1428EGA Buenos Aires, Argentina
IQUIBICEN (CONICET-UBA), Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pab.2, Piso 4. Ciudad Universitaria, 1428EGA Buenos Aires, Argentina
Palabras clave:Cytokines; Herpes; Mouse; Pathology; Virulence; carrageenan; cytokine; glycoprotein D; interleukin 6; tumor necrosis factor alpha; cytokine; glycoprotein D, Human herpesvirus 1; virus envelope protein; animal cell; animal experiment; animal model; animal tissue; article; controlled study; cytokine release; female; gene sequence; Herpes simplex virus 1; Herpes simplex virus 1 (syn14-1 variant); Herpes simplex virus 1 (syn17-21 variant); immune response; immunocompetent cell; lung alveolus macrophage; lung infection; lung parenchyma; mouse; nonhuman; point mutation; priority journal; protein expression; virus replication; virus strain; animal; Bagg albino mouse; genetics; Herpes simplex virus 1; immunology; mucosa; pathology; respiratory tract infection; secretion (process); virology; Animalia; Herpes; Human herpesvirus 1; Mus; Animals; Cytokines; Female; Herpesvirus 1, Human; Mice; Mice, Inbred BALB C; Mucous Membrane; Point Mutation; Respiratory Tract Infections; Viral Envelope Proteins
Año:2014
Volumen:71-72
Número:1
Página de inicio:68
Página de fin:72
DOI: http://dx.doi.org/10.1016/j.micpath.2014.04.004
Título revista:Microbial Pathogenesis
Título revista abreviado:Microb. Pathog.
ISSN:08824010
CODEN:MIPAE
CAS:carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; Cytokines; glycoprotein D, Human herpesvirus 1; Viral Envelope Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08824010_v71-72_n1_p68_CarolinaArtuso

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Citas:

---------- APA ----------
Carolina Artuso, M., Linero, F.N., Gazzaniga, S., Scolaro, L.A., Pujol, C.A., Wainstok, R. & Carlucci, M.J. (2014) . Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1. Microbial Pathogenesis, 71-72(1), 68-72.
http://dx.doi.org/10.1016/j.micpath.2014.04.004
---------- CHICAGO ----------
Carolina Artuso, M., Linero, F.N., Gazzaniga, S., Scolaro, L.A., Pujol, C.A., Wainstok, R., et al. "Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1" . Microbial Pathogenesis 71-72, no. 1 (2014) : 68-72.
http://dx.doi.org/10.1016/j.micpath.2014.04.004
---------- MLA ----------
Carolina Artuso, M., Linero, F.N., Gazzaniga, S., Scolaro, L.A., Pujol, C.A., Wainstok, R., et al. "Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1" . Microbial Pathogenesis, vol. 71-72, no. 1, 2014, pp. 68-72.
http://dx.doi.org/10.1016/j.micpath.2014.04.004
---------- VANCOUVER ----------
Carolina Artuso, M., Linero, F.N., Gazzaniga, S., Scolaro, L.A., Pujol, C.A., Wainstok, R., et al. Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1. Microb. Pathog. 2014;71-72(1):68-72.
http://dx.doi.org/10.1016/j.micpath.2014.04.004