Artículo

Mistchenko, A.S.; Koch, E.R.R.; Kajon, A.E.; Tibaldi, F.; Maffey, A.F.; Diez, R.A. "Lymphocyte subsets and cytokines in adenoviral infection in children" (1998) Acta Paediatrica, International Journal of Paediatrics. 87(9):933-939
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Abstract:

To determine the distribution of major blood lymphocyte subsets we evaluated blood lymphocytes by flow cytometry in adenovirus-infected infants aged 30-730 d. In addition, interleukin-1-receptor antagonist, interleukin- 10 and transforming growth factor-β1 were measured in serum by enzyme- linked immunosorbent assay. According to clinical parameters, mechanical ventilation and outcome, infections were classified as moderate (n = 15), severe (n = 11) and fatal (n = 12). Controls were 13 healthy children. In severe and fatal infection, T cells (CD5+/CD19-), NK effectors (CD16+), CD4+ T subset and B1 subset of B lymphocytes (CD5+/CD19+) were all significantly decreased. CD8+ cells were decreased in severe but not fatal cases. There was no difference in serum values of interleukin-10; however, fatal cases had high interleukin 1-receptor antagonist values. Interestingly, patients with moderate infection showed significantly increased values of transforming growth factor-β1. These results demonstrate that life- threatening adenoviral infection is associated with marked abnormalities in blood lymphocyte and cytokine profile.

Registro:

Documento: Artículo
Título:Lymphocyte subsets and cytokines in adenoviral infection in children
Autor:Mistchenko, A.S.; Koch, E.R.R.; Kajon, A.E.; Tibaldi, F.; Maffey, A.F.; Diez, R.A.
Filiación:Laboratorio de Virología, Hosp. de Ninos R. Gutierrez, Argentina
Unidad de Terapia Intensiva, Hosp. de Ninos R. Gutierrez, Argentina
Departamento de Microbiología, Universidad de Buenos Aires, Argentina
Instituto de Cálculo, Facultad de Ciencias Exactas, Universidad de Buenos Aires, Argentina
Centro Respiratorio, Hosp. de Ninos R. Gutierrez, Argentina
Departamento de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Argentina
Laboratorio de Virología, Hosp. de Ninos R. Gutierrez, Gallo 1330, (1425) Buenos Aires, Argentina
Palabras clave:Adenovirus; Cytokines; Lymphocytes; Respiratory infection; cd16 antigen; cd19 antigen; cd4 antigen; cd5 antigen; cd8 antigen; cytokine; interleukin 1 receptor blocking agent; interleukin 10; transforming growth factor beta1; adenovirus; article; artificial ventilation; clinical article; controlled study; female; helper cell; human; infant; inflammation; male; natural killer cell; preschool child; priority journal; respiratory tract infection; t lymphocyte; t lymphocyte subpopulation; virus infection; Adenoviridae Infections; Child, Preschool; Cytokines; Female; Humans; Infant; Lymphocyte Subsets; Male; Phenotype
Año:1998
Volumen:87
Número:9
Página de inicio:933
Página de fin:939
DOI: http://dx.doi.org/10.1080/080352598750031572
Título revista:Acta Paediatrica, International Journal of Paediatrics
Título revista abreviado:Acta Paediatr. Int. J. Paediatr.
ISSN:08035253
CODEN:APAEE
CAS:Cytokines
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08035253_v87_n9_p933_Mistchenko

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Citas:

---------- APA ----------
Mistchenko, A.S., Koch, E.R.R., Kajon, A.E., Tibaldi, F., Maffey, A.F. & Diez, R.A. (1998) . Lymphocyte subsets and cytokines in adenoviral infection in children. Acta Paediatrica, International Journal of Paediatrics, 87(9), 933-939.
http://dx.doi.org/10.1080/080352598750031572
---------- CHICAGO ----------
Mistchenko, A.S., Koch, E.R.R., Kajon, A.E., Tibaldi, F., Maffey, A.F., Diez, R.A. "Lymphocyte subsets and cytokines in adenoviral infection in children" . Acta Paediatrica, International Journal of Paediatrics 87, no. 9 (1998) : 933-939.
http://dx.doi.org/10.1080/080352598750031572
---------- MLA ----------
Mistchenko, A.S., Koch, E.R.R., Kajon, A.E., Tibaldi, F., Maffey, A.F., Diez, R.A. "Lymphocyte subsets and cytokines in adenoviral infection in children" . Acta Paediatrica, International Journal of Paediatrics, vol. 87, no. 9, 1998, pp. 933-939.
http://dx.doi.org/10.1080/080352598750031572
---------- VANCOUVER ----------
Mistchenko, A.S., Koch, E.R.R., Kajon, A.E., Tibaldi, F., Maffey, A.F., Diez, R.A. Lymphocyte subsets and cytokines in adenoviral infection in children. Acta Paediatr. Int. J. Paediatr. 1998;87(9):933-939.
http://dx.doi.org/10.1080/080352598750031572