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Abstract:

Up to now, only glucocorticoids were thought to act on the renal proximal Na+/H+ exchanger. Using fluorimetric techniques we studied the kinetics of Na+/H+ exchange in brush border vesicles from ADX rats treated with increasing doses of corticosterone (B) and 18-hydroxycorticosterone (18OHB). Significant linear correlations were obtained when the Vmax of each treatment were plotted against log doses. 18OHB exhibits a slightly higher sensitivity than B and log-dose responses were steeper for 18OHB than for B treated rats. Differences between both treatments were highly significant at the 4.8 μg/100 g level, corresponding to the physiological blood level of 18OHB. Physiological doses of both steroids elicited equal Na+/H+ exchange- responses. 18OHB is not a glucocorticoid since even 88μg/100g did not promote hepatic glycogen deposition while the same dose of B increases glycogen deposits 3.5-fold. These results demonstrate the importance of the Na+/H+ exchanger as a mediator between corticoid action and H+ transport and that of the non-glucocorticoid 18OHB in this process.

Registro:

Documento: Artículo
Título:Dose-dependence of the effects of corticosterone and the non- glucocorticoid, 18-hydroxycorticosterone, on the brush-border Na+/K+ exchanger
Autor:Igarreta, P.; Lantos, C.P.; Calvo, J.C.; Paladini, A.A.; Damasco, M.C.
Filiación:Lab. de Esteroides, FCEN UBA, Cdad. Universitaria Pab.2, (1428) Buenos Aires, Argentina
PRHOM-CONICET, Buenos Aires, Argentina
IBYME, Buenos Aires, Argentina
INGEBI, Buenos Aires, Argentina
Palabras clave:18 hydroxycorticosterone; adenosine triphosphatase (potassium sodium); corticosterone; animal tissue; brush border; conference paper; dose response; fluorometry; glycogen synthesis; hormone action; male; nonhuman; potassium transport; priority journal; proton transport; rat; sodium transport; transport kinetics
Año:1998
Volumen:24
Número:3-4
Página de inicio:601
Página de fin:605
DOI: http://dx.doi.org/10.3109/07435809809032653
Título revista:Endocrine Research
Título revista abreviado:Endocr. Res.
ISSN:07435800
CODEN:ENRSE
CAS:18 hydroxycorticosterone, 561-65-9; adenosine triphosphatase (potassium sodium); corticosterone, 50-22-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07435800_v24_n3-4_p601_Igarreta

Referencias:

  • Welbourne, T.C., (1979) Endocrinology, 99, pp. 1071-1079
  • Malnic, G., Ansaldo, M., Lantos, C.P., Damasco, M.C., (1997) Braz J Med Biol Res, 30, pp. 479-486
  • Igarreta, P., Calvo, J.C., Paladini, A.A., Damasco, M.C., (1997) Can J Physiol Pharmacol, 75, pp. 1226-1231
  • Aronson, P.S., (1983) Am J Physiol, 245, pp. 647-659
  • Krisman, C.R., (1962) Analytical Biochemistry, 4, pp. 17-23
  • Schoeneshofer, M., Frenner, A., Dulce, H.J., (1981) J Steroid Biochem, 14, pp. 377-386
  • Sandor, T., Lamourex, J., Lanthier, A., (1964) Steroids, 4, pp. 213-228
  • Borruel, M., Borruel, P., Damasco, M.C., Lantos, C.P., (1974) Gen. Comp. Endocr., 22, pp. 1-12
  • Fraser, R., Lantos, C.P., (1978) J Steroid Biochem, 9, pp. 273-294
  • Feldman, D., Funder, J.W., (1973) Endocrinology, 92, pp. 1389-1396
  • Damasco, M.C., Magarinos, A.M., Lantos, C.P., De Nicola, A.F., (1992) Acta Physiol Pharmacol Latinoam, 42, pp. 27-34

Citas:

---------- APA ----------
Igarreta, P., Lantos, C.P., Calvo, J.C., Paladini, A.A. & Damasco, M.C. (1998) . Dose-dependence of the effects of corticosterone and the non- glucocorticoid, 18-hydroxycorticosterone, on the brush-border Na+/K+ exchanger. Endocrine Research, 24(3-4), 601-605.
http://dx.doi.org/10.3109/07435809809032653
---------- CHICAGO ----------
Igarreta, P., Lantos, C.P., Calvo, J.C., Paladini, A.A., Damasco, M.C. "Dose-dependence of the effects of corticosterone and the non- glucocorticoid, 18-hydroxycorticosterone, on the brush-border Na+/K+ exchanger" . Endocrine Research 24, no. 3-4 (1998) : 601-605.
http://dx.doi.org/10.3109/07435809809032653
---------- MLA ----------
Igarreta, P., Lantos, C.P., Calvo, J.C., Paladini, A.A., Damasco, M.C. "Dose-dependence of the effects of corticosterone and the non- glucocorticoid, 18-hydroxycorticosterone, on the brush-border Na+/K+ exchanger" . Endocrine Research, vol. 24, no. 3-4, 1998, pp. 601-605.
http://dx.doi.org/10.3109/07435809809032653
---------- VANCOUVER ----------
Igarreta, P., Lantos, C.P., Calvo, J.C., Paladini, A.A., Damasco, M.C. Dose-dependence of the effects of corticosterone and the non- glucocorticoid, 18-hydroxycorticosterone, on the brush-border Na+/K+ exchanger. Endocr. Res. 1998;24(3-4):601-605.
http://dx.doi.org/10.3109/07435809809032653