Artículo

Gomez-Sanchez, C.E.; Zhou, M.Y.; Cozza, E.N.; Morita, H.; Eddleman, F.C.; Gomez-Sanchez, E.P. "Corticosteroid synthesis in the central nervous system" (1996) Endocrine Research. 22(4):463-470
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Abstract:

The possibility that adrenocorticosteroids might be synthesized in the central nervous system was assessed by RT-PCR using primers for the CYP11B1 gene which codes for 11β-hydroxylase, the enzyme responsible for corticosterone and cortisol formation in the zona fasciculata, incubation of minces of several areas of the brain with 3H-DOC and measuring steroid metabolites, and determining the effect of the intracerebroventricular infusion of the 11β-hydroxylase mechanism-based inhibitor 19- ethynyldeoxycorticosterone upon the salt-induced increase in blood pressure in SS/jr rats. Significant, though small relative to the adrenal, amounts of mRNA for 11β-hydroxylase was found in the aorta, cerebrum, cerebellum, hippocampus, hypothalamus and amygdala, but not in the heart. Brain minces converted 3H-DOC to corticosterone and 11-dehydrocorticosterone to a greater degree than to 18-OH-DOC. The effect of 19- ethynyldeoxycorticosterone was dose dependent, with the lower doses preventing salt-induced hypertension and the higher doses having no effect or increasing the blood pressure.

Registro:

Documento: Artículo
Título:Corticosteroid synthesis in the central nervous system
Autor:Gomez-Sanchez, C.E.; Zhou, M.Y.; Cozza, E.N.; Morita, H.; Eddleman, F.C.; Gomez-Sanchez, E.P.
Filiación:Department of Internal Medicine, Harry S. Truman Mem. Vet. Hospital, University of Missouri-Columbia, Columbia, MO, United States
Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:19 ethynyldeoxycorticosterone; corticosterone; dehydrocorticosterone; steroid 11beta monooxygenase; steroid 11beta monooxygenase inhibitor; unclassified drug; animal cell; animal tissue; blood pressure measurement; central nervous system function; conference paper; dose response; enzyme mechanism; hypertension; inhibition kinetics; intracerebroventricular drug administration; male; nonhuman; priority journal; rat; steroidogenesis; tissue distribution
Año:1996
Volumen:22
Número:4
Página de inicio:463
Página de fin:470
DOI: http://dx.doi.org/10.1080/07435809609043732
Título revista:Endocrine Research
Título revista abreviado:ENDOCR. RES.
ISSN:07435800
CODEN:ENRSE
CAS:corticosterone, 50-22-6; dehydrocorticosterone, 72-23-1; steroid 11beta monooxygenase, 9029-66-7, 9054-99-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07435800_v22_n4_p463_GomezSanchez

Referencias:

  • LeGoascogne, C., Robe, P., Gouezou, M., Sananes, N., Baulieu, E.E., Waterman, M., (1987) Science, 237, pp. 1212-1215
  • Mellon, S.H., (1994) J Clin Endocrinol Metab, 78, pp. 1003-1008
  • Paul, S.M., Purdy, R.H., (1992) FASEB J, 6, pp. 2311-2322
  • Selye, H., (1941) Pro.Soc.Exp.Biol.Med., 46, pp. 116-121
  • Robel, P., Baulieu, E.E., (1994) TEM, 5, pp. 1-8
  • Mellon, S.H., Deschepper, C.F., (1993) Brain Res, 629, pp. 283-292
  • Ozaki, H.S., Iwahashi, K., Tsubaki, M., Fukui, Y., Ichikawa, Y., Takeuchi, Y., (1991) J Neurosci Res, 28, pp. 518-524
  • Casey, M.L., MacDonald, P.C., (1982) Endocr Rev, 3, pp. 396-403
  • Iwahashi, K., Ozaki, H.S., Tsubaki, M., Ohnishi, J., Takeuchi, Y., Ichikawa, Y., (1990) Biochem Biophy Acta, 1035, pp. 182-189
  • Compagnone, N.A., Bulfone, A., Rubenstein, J.L.R., Mellon, S.H., (1995) Endocrinology, 136, pp. 2689-2696
  • Koenig, H.L., Schumacher, M., Ferzaz, B., Do Thi, A.N., Ressouches, A., Guennoun, R., Jung-Testas, I., Baulieu, E.E., (1995) Science, 268, pp. 1500-1503
  • Iwahashi, K., Kawai, Y., Suwaki, H., Hosokawa, K., Ichikawa, Y., (1993) J Steroid Biochem Mol Biol, 44, pp. 163-169
  • Mellon, S.H., Miller, W.L., (1989) J.Clin.Invest., 84, pp. 1497-1502
  • Zhou, M., Gomez-Sanchez, E.P., Foecking, M.F., Gomez-Sanchez, C.E., (1995) Molecular Cellular Endocrinology, 114, pp. 137-145
  • Wright, C.L., Holbert, G.H., Safi, E., Robinson, C.H., Johnston, J.O., (1991) Proc 73rd Endocrine Soc, p. 670. , Abstract
  • Azar, S.T., Melby, J.C., Griffing, G.T., Holbrook, M., Johnston, J.O., (1992) Am J Hypertens, 5, pp. 372-377
  • Gomez-Sanchez, E.P., Gomez-Sanchez, C.E., (1995) Am J Physiol, 269, pp. H1044-H1047
  • Chomczynski, P., Sacchi, N., (1987) Anal Biochem, 162, pp. 156-159
  • Gomez-Sanchez, E.P., (1988) J Hypertension, 6, pp. 437-442
  • Gomez-Sanchez, E.P., Adrenocorticosteroids and cardiovascular regulation: Methods for surgery and blood pressure measurements (1994) Methods in Neurosciences: Neurobiology of Steroids, pp. 496-509. , edited by De Kloet, E.R. and Sutanto, W. Orlando,FL: Academic Press, Inc
  • Roland, B.L., Li, K.X.Z., Funder, J.W., (1995) Endocrinology, 136, pp. 4697-4700
  • Gomez-Sanchez, E.P., Fort, C., Thwaites, D., (1992) Am.J.Physiol., 262, pp. E96-E99
  • Jellinck, P.H., Monder, C., McEwen, B.S., Sakai, R.R., (1993) J Steroid Biochem Mol Biol, 46, pp. 209-213
  • Gomez-Sanchez, E.P., Gomez-Sanchez, C.E., (1988) Endocrinology, 122, pp. 1110-1113
  • Viger, A., Coustal, S., Perard, S., Piffeteau, A., Marquet, A., (1989) J Steroid Biochem, 33, pp. 119-124

Citas:

---------- APA ----------
Gomez-Sanchez, C.E., Zhou, M.Y., Cozza, E.N., Morita, H., Eddleman, F.C. & Gomez-Sanchez, E.P. (1996) . Corticosteroid synthesis in the central nervous system. Endocrine Research, 22(4), 463-470.
http://dx.doi.org/10.1080/07435809609043732
---------- CHICAGO ----------
Gomez-Sanchez, C.E., Zhou, M.Y., Cozza, E.N., Morita, H., Eddleman, F.C., Gomez-Sanchez, E.P. "Corticosteroid synthesis in the central nervous system" . Endocrine Research 22, no. 4 (1996) : 463-470.
http://dx.doi.org/10.1080/07435809609043732
---------- MLA ----------
Gomez-Sanchez, C.E., Zhou, M.Y., Cozza, E.N., Morita, H., Eddleman, F.C., Gomez-Sanchez, E.P. "Corticosteroid synthesis in the central nervous system" . Endocrine Research, vol. 22, no. 4, 1996, pp. 463-470.
http://dx.doi.org/10.1080/07435809609043732
---------- VANCOUVER ----------
Gomez-Sanchez, C.E., Zhou, M.Y., Cozza, E.N., Morita, H., Eddleman, F.C., Gomez-Sanchez, E.P. Corticosteroid synthesis in the central nervous system. ENDOCR. RES. 1996;22(4):463-470.
http://dx.doi.org/10.1080/07435809609043732