Corticosterone (B) and 18-hydroxy-11-deoxycorticosterone (18OHDOC) but not 11-deoxycorticosterone (DOC) displaced cortisol (F) specifically bound to rat adrenal mitochondria. F competitively inhibited aldosterone formation from B, 18OHB and 18OHDOC but did not inhibit conversions of DOC to B or 18OHDOC. High concentrations of DOC increased its conversion to 18OHDOC rather than B. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Documento: | Artículo |
Título: | Cortisol: A tool to study aldosterone biosynthesis in rats |
Autor: | Matkovic, L.; Gomez-sanchez, C.E.; Lantos, C.P.; Cozza, E.N. |
Filiación: | Departamento de Química Biológica, Facultad de Cs. Exactas y Naturales-UBA and PRHOM-CONICET, Buenos, Aires-1428, Argentina Department of Internal Medicine, Harry S Truman Veterans' Hospital, University of Missouri, Columbia, MO, 65201, United States |
Palabras clave: | 18 hydroxydeoxycorticosterone; aldosterone; corticosterone; cytochrome p450; deoxycorticosterone; hydrocortisone; steroid 11beta monooxygenase; adrenal cortex; animal tissue; conference paper; controlled study; enzyme activity; enzyme substrate; male; mitochondrion; nonhuman; priority journal; rat; steroidogenesis; 18-Hydroxydesoxycorticosterone; Adrenal Glands; Aldosterone; Animal; Binding, Competitive; Corticosterone; Hydrocortisone; Male; Mitochondria; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S. |
Año: | 1995 |
Volumen: | 21 |
Número: | 1-2 |
Página de inicio: | 471 |
Página de fin: | 475 |
DOI: | http://dx.doi.org/10.3109/07435809509030464 |
Título revista: | Endocrine Research |
Título revista abreviado: | Endocr. Res. |
ISSN: | 07435800 |
CODEN: | ENRSE |
CAS: | 18 hydroxydeoxycorticosterone, 379-68-0; aldosterone, 52-39-1, 6251-69-0; corticosterone, 50-22-6; cytochrome P450, 9035-51-2; deoxycorticosterone, 64-85-7; hydrocortisone, 50-23-7; steroid 11beta monooxygenase, 9029-66-7, 9054-99-3; 18-Hydroxydesoxycorticosterone; Aldosterone, 52-39-1; Corticosterone, 50-22-6; Hydrocortisone, 50-23-7 |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07435800_v21_n1-2_p471_Matkovic |