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Abstract:

Corticosterone (B) and 18-hydroxy-11-deoxycorticosterone (18OHDOC) but not 11-deoxycorticosterone (DOC) displaced cortisol (F) specifically bound to rat adrenal mitochondria. F competitively inhibited aldosterone formation from B, 18OHB and 18OHDOC but did not inhibit conversions of DOC to B or 18OHDOC. High concentrations of DOC increased its conversion to 18OHDOC rather than B. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Registro:

Documento: Artículo
Título:Cortisol: A tool to study aldosterone biosynthesis in rats
Autor:Matkovic, L.; Gomez-sanchez, C.E.; Lantos, C.P.; Cozza, E.N.
Filiación:Departamento de Química Biológica, Facultad de Cs. Exactas y Naturales-UBA and PRHOM-CONICET, Buenos, Aires-1428, Argentina
Department of Internal Medicine, Harry S Truman Veterans' Hospital, University of Missouri, Columbia, MO, 65201, United States
Palabras clave:18 hydroxydeoxycorticosterone; aldosterone; corticosterone; cytochrome p450; deoxycorticosterone; hydrocortisone; steroid 11beta monooxygenase; adrenal cortex; animal tissue; conference paper; controlled study; enzyme activity; enzyme substrate; male; mitochondrion; nonhuman; priority journal; rat; steroidogenesis; 18-Hydroxydesoxycorticosterone; Adrenal Glands; Aldosterone; Animal; Binding, Competitive; Corticosterone; Hydrocortisone; Male; Mitochondria; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
Año:1995
Volumen:21
Número:1-2
Página de inicio:471
Página de fin:475
DOI: http://dx.doi.org/10.3109/07435809509030464
Título revista:Endocrine Research
Título revista abreviado:Endocr. Res.
ISSN:07435800
CODEN:ENRSE
CAS:18 hydroxydeoxycorticosterone, 379-68-0; aldosterone, 52-39-1, 6251-69-0; corticosterone, 50-22-6; cytochrome P450, 9035-51-2; deoxycorticosterone, 64-85-7; hydrocortisone, 50-23-7; steroid 11beta monooxygenase, 9029-66-7, 9054-99-3; 18-Hydroxydesoxycorticosterone; Aldosterone, 52-39-1; Corticosterone, 50-22-6; Hydrocortisone, 50-23-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07435800_v21_n1-2_p471_Matkovic

Referencias:

  • Matsuwaka, N., Nonaka, Y., Ying, Z., Matsushima-Hibiya, Y., Ogishima, T., Okamoto, M., (1990) Biochem Biophys Res Commun, 169, pp. 245-252
  • Imai, M., Shimada, H., Okada, Y., Matsushima-Hibiya, Y., Ogishima, T., Ishimura, Y., (1990) Febbs Lett, 263, pp. 299-302
  • Okamoto, M., Nonaka, Y., (1992) J Steroid Biochem Mol Biol, 41, pp. 415-419
  • Oertle, M., Müller, J., (1993) Mol Cel Endocrinol, 91, pp. 201-209
  • Ho, M.M., Vinson, G.P., (1993) Journal of Endocrinology, 139, pp. 301-306
  • Ceballos, N.R., Cozza, E.N., Lantos, C.P., (1983) Gen Comp Endocrinol, 51, pp. 138-147
  • Cozza, E.N., Foecking, M.F., Gomez-Sanchez, C.E., (1990) J Steroid Biochem, 35, pp. 511-514
  • Bradford, M.M., (1976) Anal Biochem, 72, pp. 248-254

Citas:

---------- APA ----------
Matkovic, L., Gomez-sanchez, C.E., Lantos, C.P. & Cozza, E.N. (1995) . Cortisol: A tool to study aldosterone biosynthesis in rats. Endocrine Research, 21(1-2), 471-475.
http://dx.doi.org/10.3109/07435809509030464
---------- CHICAGO ----------
Matkovic, L., Gomez-sanchez, C.E., Lantos, C.P., Cozza, E.N. "Cortisol: A tool to study aldosterone biosynthesis in rats" . Endocrine Research 21, no. 1-2 (1995) : 471-475.
http://dx.doi.org/10.3109/07435809509030464
---------- MLA ----------
Matkovic, L., Gomez-sanchez, C.E., Lantos, C.P., Cozza, E.N. "Cortisol: A tool to study aldosterone biosynthesis in rats" . Endocrine Research, vol. 21, no. 1-2, 1995, pp. 471-475.
http://dx.doi.org/10.3109/07435809509030464
---------- VANCOUVER ----------
Matkovic, L., Gomez-sanchez, C.E., Lantos, C.P., Cozza, E.N. Cortisol: A tool to study aldosterone biosynthesis in rats. Endocr. Res. 1995;21(1-2):471-475.
http://dx.doi.org/10.3109/07435809509030464