Artículo
Cochón, A.C.; San Martín de Viale, L.C.; Wainstok de Calmanovici, R. "Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo." (1992) Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. 102(1):143-148
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Abstract:
1. Some studies of cyclophosphamide (CP) and its metabolite acrolein in chick embryo liver were carried out in order to investigate the mechanism of the porphyrinogenic action of CP. 2. In vitro and in vivo studies revealed that CP induced but did not activate delta-aminolaevulinic acid (ALA) synthase. 3. Pretreatments with phenobarbital (PB) or SKF-525A did not modify ALA-synthase induction produced by CP. 4. Acrolein administration neither induced ALA-synthase activity nor increased cytochrome P-450 content or led to hepatic porphyrin accumulation. 5. Time course induction of cytochrome P-450 content after administration of CP or PB was similar. 6. The results obtained would indicate that CP is a strong inducer of both ALA-synthase activity and microsomal cytochrome P-450 content in liver of 17 day-old chick embryos and that its porphyrinogenic activity is not mediated by its metabolite acrolein.
Registro:
| Documento: | Artículo |
| Título: | Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo. |
| Autor: | Cochón, A.C.; San Martín de Viale, L.C.; Wainstok de Calmanovici, R. |
| Filiación: | Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina. |
| Idioma: | Inglés |
| Palabras clave: | 5 aminolevulinate synthase; acrolein; allylisopropylacetamide; cyclophosphamide; Cytochrome P 450 Enzyme System; cytochrome P450; phenobarbital; porphyrin; proadifen; animal; article; biosynthesis; chemical structure; chemistry; chick embryo; drug effect; enzyme induction; enzymology; gestational age; liver; metabolism; 5-Aminolevulinate Synthetase; Acrolein; Allylisopropylacetamide; Animal; Chick Embryo; Cyclophosphamide; Cytochrome P-450 Enzyme System; Enzyme Induction; Gestational Age; Liver; Molecular Structure; Phenobarbital; Porphyrins; Proadifen; Support, Non-U.S. Gov't |
| Año: | 1992 |
| Volumen: | 102 |
| Número: | 1 |
| Página de inicio: | 143 |
| Página de fin: | 148 |
| Título revista: | Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology |
| Título revista abreviado: | Comp Biochem Physiol C |
| ISSN: | 07428413 |
| CAS: | 5 aminolevulinate synthase, 9037-14-3; acrolein, 107-02-8; allylisopropylacetamide, 299-78-5; cyclophosphamide, 50-18-0; cytochrome P450, 9035-51-2; phenobarbital, 50-06-6, 57-30-7, 8028-68-0; porphyrin, 24869-67-8; proadifen, 302-33-0, 62-68-0; 5-Aminolevulinate Synthetase, EC 2.3.1.37; Acrolein, 107-02-8; Allylisopropylacetamide, 299-78-5; Cyclophosphamide, 50-18-0; Cytochrome P-450 Enzyme System, 9035-51-2; Phenobarbital, 50-06-6; Porphyrins; Proadifen, 302-33-0 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07428413_v102_n1_p143_Cochon |
Citas:
---------- APA ----------
Cochón, A.C., San Martín de Viale, L.C. & Wainstok de Calmanovici, R. (1992) . Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 102(1), 143-148.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07428413_v102_n1_p143_Cochon [ ]
---------- CHICAGO ----------
Cochón, A.C., San Martín de Viale, L.C., Wainstok de Calmanovici, R. "Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo." Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 102, no. 1 (1992) : 143-148.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07428413_v102_n1_p143_Cochon [ ]
---------- MLA ----------
Cochón, A.C., San Martín de Viale, L.C., Wainstok de Calmanovici, R. "Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo." Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, vol. 102, no. 1, 1992, pp. 143-148.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07428413_v102_n1_p143_Cochon [ ]
---------- VANCOUVER ----------
Cochón, A.C., San Martín de Viale, L.C., Wainstok de Calmanovici, R. Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo. Comp Biochem Physiol C. 1992;102(1):143-148.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07428413_v102_n1_p143_Cochon [ ]
