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Abstract:

Accumulation of 8-aminolevulinic acid (ALA), as it occurs in acute intermittent porphyria, is a potential endogenous source of reactive oxygen species (ROS) which can then produce oxidative damage to cell structures and macromolecules. This in vivo study investigated whether melatonin could prevent the deleterious effects of ALA. Rats were injected i.p. for 2 weeks with ALA (40 mg/kg on alternate days) and/or with melatonin (50 μg/kg or 500 μg/kg daily). Administration of pharmacological doses of melatonin reduced and/or prevented ALA-induced lipid peroxidation (LPO) in both cerebral cortex and cerebellum, providing further evidence of melatonin's action as a ROS scavenger. Administration of pharmacological concentrations of melatonin to ALA-injected rats showed the protective properties of melatonin on the activities of both porphobilinogen-deaminase and δ-aminolevulinate dehydratase (ALA-D) in the cerebral cortex; the effect on ALA-D activity was unexpectedly high (at least 6-fold), indicating that, besides acting as a scavenger of hydroxyl radicals, melatonin may exert its protection on ALA-D through other mechanisms, such as increasing mRNA levels of antioxidant enzymes or/ and inducing glutathione peroxidase activity. The possibility that changes in the expression of antioxidant enzymes could affect the expression of other proteins, even those not related to the cellular ROS homeostasis, should also not be discarded. The potential use of melatonin as an antioxidant and for its reactivating properties in the treatment of acute porphyrias is considered.

Registro:

Documento: Artículo
Título:In vivo protection by melatonin against δ-aminolevulinic acid-induced oxidative damage and its antioxidant effect on the activity of haem enzymes
Autor:Princ, F.G.; Maxit, A.G.; Cardalda, C.; Batlle, A.; Juknat, A.A.
Filiación:Ctro. Invest. sobre Porfirinas y P., Depto. de Quim. Biológica, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Viamonte 1881 - 10A, 1056 Buenos Aires, Argentina
Palabras clave:δ-aminolevulinate dehydratase; δ-aminolevulinic acid; Antioxidative enzymes; Melatonin; Porphobilinogen deaminase; Reactive oxygen species; aminolevulinic acid; antioxidant; melatonin; porphobilinogen deaminase; porphobilinogen synthase; animal experiment; animal tissue; article; brain cortex; brain injury; cerebellum; controlled study; intraperitoneal drug administration; lipid peroxidation; male; neuroprotection; nonhuman; oxidative stress; rat; Aminolevulinic Acid; Animals; Antioxidants; Cerebellum; Cerebral Cortex; Free Radical Scavengers; Hydroxymethylbilane Synthase; Injections, Intraperitoneal; Lipid Peroxidation; Male; Malondialdehyde; Melatonin; Oxidative Stress; Porphobilinogen Synthase; Rats; Reactive Oxygen Species
Año:1998
Volumen:24
Número:1
Página de inicio:1
Página de fin:8
DOI: http://dx.doi.org/10.1111/j.1600-079X.1998.tb00359.x
Título revista:Journal of Pineal Research
Título revista abreviado:J. Pineal Res.
ISSN:07423098
CODEN:JPRSE
CAS:Aminolevulinic Acid, 106-60-5; Antioxidants; Free Radical Scavengers; Hydroxymethylbilane Synthase, EC 2.5.1.61; Malondialdehyde, 542-78-9; Melatonin, 73-31-4; Porphobilinogen Synthase, EC 4.2.1.24; Reactive Oxygen Species
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07423098_v24_n1_p1_Princ

Referencias:

  • Acuña-Castroviejo, D., Fernandez, B., Delaguila, C.M., Castillo, J.L., Lesions in suprachiasmatic nuclei simulate effects of pinealectomy on prolactin release in ovariectomized and sulpiride-treated female rats (1989) Experientia, 45, pp. 739-742
  • Antolin, I., Rodriguez, C., Sainz, R.M., Mayo, J.C., Uria, H., Kotler, M.L., Rodriguez-Colunga, M.J., Menendez-Pelaez, A., Neurohormone melatonin prevents cell damage: Effect on gene expression for antioxidant enzymes (1996) FASEB J., 10, pp. 882-890
  • Babior, B.M., Oxygen-dependent microbial killing by phagocytes (1978) N. Engl. J. Med., 298, pp. 721-725
  • Barlow-Walden, L., Reiter, R.J., Abe, M., Pablos, M., Menendez-Pelaez, A., Chen, L., Poeggeler, B., Melatonin stimulates brain glutathione peroxidase activity (1995) Neurochem. Int., 26, pp. 497-502
  • Batlle, A., Lead intoxication and acute porphyria: Development and positive experience in their therapy (1986) Porphyrins and Porphyrias, 134, pp. 189-200. , Y. Nordmann, ed., John Libbey Eurotext Ltd, London
  • Bauerle, P.A., Henkel, T., Function and activation of NF-κB in the immune system (1994) Annu. Rev. Immunol., 12, pp. 141-179
  • Beal, M.F., Aging, energy and oxidative stress in neurodegenerative diseases (1995) Ann. Neurol., 38, pp. 357-366
  • Bechara, E.J.H., Oxidative stress in acute intermittent porphyria and lead poisoning may be triggered by 5-aminolevulinic acid (1996) Braz. J. Med. Biol. Res., 29, pp. 841-851
  • Benitez-King, G., Anton-Tay, F., Calmodulin mediates melatonin cytoskeletal effects (1993) Experientia, 49, pp. 635-640
  • Bonkowsky, H.L., Schady, W., Neurologic manifestations of acute porphyria (1982) Semin. Liver Dis., 2, pp. 108-124
  • Buege, J.A., Aust, S.D., Microsomal lipid peroxidation (1978) Methods Enzymol., 52, pp. 302-310
  • Cardinali, D.P., Melatonin a mammalian pineal hormone (1981) Endocr. Rev., 2, pp. 327-354
  • Carneiro, R.C.G., Reiter, R.J., Melatonin protects against lipid peroxidation induced by δ-aminolevulinic acid in rat cerebellum, cortex and hippocampus (1977) Neuroscience, , in press
  • Chuang, J.I., Mohan, N., Meltz, M.L., Reiter, R.J., Effect of melatonin on NF-κB DNA-binding activity in the rat spleen (1996) Cell Biol. Int., 20, pp. 687-692
  • Coyle, J.T., Puttfarcken, P., Oxidative stress, glutamate and neurodegenerative disorders (1993) Science, 262, pp. 689-695
  • Demasi, M., Penatti, C., Delucia, R., Bechara, E., The prooxidant effect of 5-aminolevulinic acid in the brain tissue of rats: Implications in neuropsychiatric manifestations in porphyrias (1996) Free Radical Biol. Med., 4, pp. 155-161
  • Halliwell, B., Reactive oxygen species and the central nervous system (1992) J. Neurochem., 59, pp. 1609-1623
  • Halliwell, B., Gutteridge, J.M.C., Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts (1986) Arch. Biochem. Biophys., 246, pp. 501-514
  • Hermes-Lima, M., Valle, V.G.R., Vercesi, A.E., Bechara, E.J.H., Damage to rat liver mitochondria promoted by -aminolevulinic acid-generated reactive oxygen species: Connections with acute intermittent porphyria and lead-poisoning (1991) Biochim. Biophys. Acta, 1056, pp. 57-63
  • Hermes-Lima, M., Castilho, R.F., Valle, V.G.R., Bechara, E.J.H., Vercesi, A.E., Calcium-dependent mitochondrial oxidative damage promoted by 5-aminolevulinic acid (1992) Biochim. Biophys. Acta, 1180, pp. 201-206
  • Juknat, A.A., Rossetti, M.V., Batlle, A., Porphyrin biosynthesis in Euglena gracilis. IV. An endogenous factor controlling the enzymatic synthesis of porphyrinogens and its possible role in the treatment of some porphyrias (1981) Int. J. Biochem., 13, pp. 343-353
  • Juknat, A.A., Kotler, M.L., Batlle, A., High -aminolevulinic acid uptake in rat cerebral cortex: Effect on porphyrin biosynthesis (1995) Comp. Biochem. Physiol., 111 C, pp. 143-150
  • Juknat, A.A., Princ, F.G., Amitrano, A.A., Batlle, A., Porphyrin biosynthesis in rat cerebellum. Effect of reactive oxygen species promoted by 5-aminolevulinic acid (1996) Second European Meeting on Glial Cell Function in Health and Disease, p. 50. , Arcachon, France. April 21-25, Abstract A70
  • Lander, H.M., A essential role for free radicals and derived species in signal transduction (1997) FASEB J., 11, pp. 118-124
  • Lerner, A.B., Case, J.D., Takahashi, Y., Lee, T.H., Mori, W., Isolation of melatonin, the pineal gland factor that lightness melanocytes (1958) J. Am. Chem. Soc., 80, p. 2587
  • Lopez-Torres, M., Perez-Campo, R., Cadenas, S., Rojas, C., Barja, G., A comparative study of free radicals in vertebrates. II. Non-enzymatic antioxidants and oxidative stress (1993) Comp. Biochem. Physiol., 105 B, pp. 757-763
  • Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the folin phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275
  • Mauzerall, D., Granick, S., The occurrence and determination of delta-aminolevulinic acid and porphobilinogen in urine (1956) J. Biol. Chem., 219, pp. 435-446
  • Medeiros, M.H.G., Marchiori, P.E., Bechara, E.J.H., Superoxide dismutase, glutathione peroxidase and catalase activities in the erythrocytes of patients with intermittent porphyria (1982) Clin. Chem., 28, p. 242
  • Melchiorri, D., Reiter, R.J., Sewerynek, E., Chen, L.D., Nistico, G., Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions (1995) FASEB J., 9, pp. 1205-1210
  • Mohan, N., Sadeghi, K., Reiter, R.J., Meltz, M.L., The neurohormone melatonin inhibits cytokine, mitogen and ionizing radiation induced by NF-κB (1995) Biochem. Mol. Biol. Int., 37, pp. 1063-1070
  • Olanow, C.W., A radical hypothesis for neuro-degeneration (1993) Trends Neurosci., 16, pp. 439-444
  • Perez-Campo, R., Lopez-Torres, M., Rojas, C., Cadenas, S., Barja, G., A comparative study of free radicals in vertebrates. I. Antioxidant enzymes (1993) Comp. Biochem. Physiol., 105 B, pp. 749-755
  • Poeggeler, B., Reiter, R.J., Tan, D.X., Chen, L.D., Manchester, L.C., Melatonin, hydroxyl radical-mediated oxidative damage, and aging: A hypothesis (1993) J. Pineal Res., 14, pp. 151-168
  • Poeggeler, B., Saarela, S., Reiter, R.J., Tan, D.X., Chen, L.D., Manchester, L.C., Barlow-Walden, L.R., Melatonin -A highly potent endogenous radical scavenger and electron donor: New aspects of the oxidation chemistry of this indole accessed in vitro (1994) Ann. N.Y. Acad. Sci., 738, pp. 419-420
  • Poeggeler, B., Reiter, R.J., Hardeland, R., Sewerynek, E., Melchiorri, D., Barlow-Walden, L.R., Melatonin, a mediator of electron transfer and repair reactions, acts sinergistically with the chain-breaking antioxidants ascorbate, trolox and glutathione (1995) Neuroendocrinol. Lett., 17, pp. 87-91
  • Princ, F.G., Juknat, A.A., Batlle, A., Porphyrinogenesis in rat cerebellum. Effect of high δ-aminolevulinic acid concentration (1994) Gen. Pharmacol., 25, pp. 761-766
  • Princ, F.G., Juknat, A.A., Maxit, A.G., Cardalda, C., Batlle, A., Melatonin's antioxidant protection against -amino-levulinic acid-induced oxidative damage in rat cerebellum (1997) J. Pineal Res., 23, pp. 40-46
  • Puy, H., Deybach, J.C., Baudry, P., Callebert, J., Touitou, Y., Nordmann, Y., Decreased nocturnal plasma melatonin levels in patients with recurrent acute intermittent porphyria attacks (1993) Life Sci., 53, pp. 621-627
  • Reiter, R.J., Oxidative processes and antioxidative defense mechanisms in the aging brain (1995) FASEB J., 9, pp. 526-533
  • Reiter, R.J., The pineal gland and melatonin in relation to aging: A summary of the theories and of the data (1995) Exp. Gerontol., 30, pp. 199-212
  • Reiter, R.J., The role of the neurohormone melatonin as a buffer against macromolecular oxidative damage (1995) Neurochem. Int., 27, pp. 453-460
  • Reiter, R.J., Oxygen radical detoxification processes during aging: The functional importance of melatonin (1996) Aging Clin. Exp. Res., 7, pp. 340-351
  • Reiter, R.J., Melchiorri, D., Sewerynek, E., Poeggeler, B., Barlow-Walden, L., Chuang, J., Ortiz, G.G., Acuña Castroviejo, D., A review of the evidence supporting melatonin's role as and antioxidant (1995) J. Pineal Res., 18, pp. 1-11
  • Rimington, C., Spectral absorption coefficients of some porphyrins in the Soret band region (1960) Biochem. J., 75, pp. 620-626
  • Rodriguez, C., Kotler, M.L., Menendez-Pelaez, A., Antolin, I., Uria, H., Reiter, R.J., Circadian rhythm in 5-aminolevulinate synthase mRNA levels in the Harderian gland of the Syrian hamster: Involvement of light:dark cycle and pineal function (1994) Endocrine, 2, pp. 863-868
  • Sancovich, H.A., Ferramola, A.M., Batlle, A., Grinstein, M., Preparation of porphobilinogen (1970) Methods in Enzymology, 17, pp. 220-222. , H. Tabor, C.W. Tabor, eds. Academic Press, New York
  • Schreck, R., Bauerle, P.A., A role for oxygen radicals as second messengers (1991) Trends Cell Biol., 1, pp. 39-42
  • Sen, C.K., Packer, L., Antioxidant and redox regulation of gene transcription (1996) FASEB J., 10, pp. 709-720
  • Stadtman, E.R., Protein oxidation and aging (1992) Science, 257, pp. 1220-1224
  • Texeira, H.D., Meneghini, R., Chinese hamster fibroblasts overexpressing CuZn-superoxide dismutase undergo a global reduction in antioxidants and an increasing sensitivity of DNA to oxidative damage (1996) Biochem. J., 315, pp. 821-825
  • Vercesi, A.E., Castilho, R.F., Meinicke, A.R., Valle, V.G.R., Hermes-Lima, M., Bechara, E.J.H., Oxidative damage of mitochondria induced by 5-aminolevulinic acid: Role of Ca2+ and membrane protein thiols (1994) Biochim. Biophys. Acta, 1188, pp. 86-92
  • Williams, L.R., Oxidative stress, age-related neuro-degeneration and the potential of neurotrophic treatment (1995) Cerebrovasc. Brain Metab. Rev., 7, pp. 55-73
  • Wolansky, M.J., Juknat, A.A., Kotler, M.L., Batlle, A., Effect of δ-aminolevulinic acid administration on porphobilinogen levels and porphyrin metabolism in the rat (1995) Pharmacol. Commun., 7, pp. 51-59
  • Yeung Laiwah, A.C., Moore, M.R., Goldberg, A., Pathogenesis of acute porphyria (1987) Q. J. Med., 63, pp. 377-392

Citas:

---------- APA ----------
Princ, F.G., Maxit, A.G., Cardalda, C., Batlle, A. & Juknat, A.A. (1998) . In vivo protection by melatonin against δ-aminolevulinic acid-induced oxidative damage and its antioxidant effect on the activity of haem enzymes. Journal of Pineal Research, 24(1), 1-8.
http://dx.doi.org/10.1111/j.1600-079X.1998.tb00359.x
---------- CHICAGO ----------
Princ, F.G., Maxit, A.G., Cardalda, C., Batlle, A., Juknat, A.A. "In vivo protection by melatonin against δ-aminolevulinic acid-induced oxidative damage and its antioxidant effect on the activity of haem enzymes" . Journal of Pineal Research 24, no. 1 (1998) : 1-8.
http://dx.doi.org/10.1111/j.1600-079X.1998.tb00359.x
---------- MLA ----------
Princ, F.G., Maxit, A.G., Cardalda, C., Batlle, A., Juknat, A.A. "In vivo protection by melatonin against δ-aminolevulinic acid-induced oxidative damage and its antioxidant effect on the activity of haem enzymes" . Journal of Pineal Research, vol. 24, no. 1, 1998, pp. 1-8.
http://dx.doi.org/10.1111/j.1600-079X.1998.tb00359.x
---------- VANCOUVER ----------
Princ, F.G., Maxit, A.G., Cardalda, C., Batlle, A., Juknat, A.A. In vivo protection by melatonin against δ-aminolevulinic acid-induced oxidative damage and its antioxidant effect on the activity of haem enzymes. J. Pineal Res. 1998;24(1):1-8.
http://dx.doi.org/10.1111/j.1600-079X.1998.tb00359.x