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Abstract:

Rat pups were treated with monoamine uptake inhibiting antidepressant drugs, desipramine, imipramine or nomifensine (5 mg/kg) during the second and third postnatal weeks, and their later behavioral "despair," measured by Porsolt's swim test, was examined. At the age of two months, the desipramine-treated rats showed lengthened immobility in the swim test, and thus probably increased behavioral "despair." They also responded to 1 g/kg alcohol by shortening the immobility to the level of control rats. Neonatal treatment with either imipramine or nomifensine did not affect the swim test behavior. The results suggest that a low, stimulatory dose of alcohol was able to reverse the lengthened immobility in the swim test of rats treated with desipramine during the early postnatal period. © 1989.

Registro:

Documento: Artículo
Título:Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs
Autor:Fernandez-Pardal, J.; Hilakivi, L.A.
Filiación:Centro de Estudios Farmacologicos, Principios Naturales (CEFAPRIN) Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), 1414 Buenos Aires, Argentina
Department of Physiology, University of Helsinki Siltavuorenpenger 20, 00170 Helsinki, Finland
Palabras clave:Alcohol; Behavioral "despair"; Desipramine; Imipramine; Neonatal; Nomifensine; alcohol; desipramine; imipramine; nomifensine; animal experiment; behavior; intraperitoneal drug administration; male; newborn; nonhuman; psychological aspect; rat; Animal; Animals, Newborn; Antidepressive Agents; Depression; Desipramine; Ethanol; Imipramine; Male; Motor Activity; Nomifensine; Rats; Rats, Inbred Strains
Año:1989
Volumen:6
Número:2
Página de inicio:93
Página de fin:95
DOI: http://dx.doi.org/10.1016/0741-8329(89)90031-1
Título revista:Alcohol
Título revista abreviado:Alcohol
ISSN:07418329
CODEN:ALCOE
CAS:alcohol, 64-17-5; desipramine, 50-47-5, 58-28-6; imipramine, 113-52-0, 50-49-7; nomifensine, 24526-64-5; Antidepressive Agents; Desipramine, 50-47-5; Ethanol, 64-17-5; Imipramine, 50-49-7; Nomifensine, 24526-64-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07418329_v6_n2_p93_FernandezPardal

Referencias:

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  • Fernandez-Pardal, Pezzot, Gimeno, Antidepressant effect of chronic ethanol in adult rats (1985) IRCS Med. Sci., 13, pp. 822-823
  • Hilakivi, Hilakivi, Increased adult behavioral “despair” in neonatally to desipramine or zimeldine exposed rats: An animal model of depression? (1987) Pharmacol. Biochem. Behav., 28, pp. 367-369
  • Hilakivi, Hilakivi, Ahtee, Haikala, Attila, Effect of neonatal nomifensine exposure on behavior and brain monoamines in adult rats (1987) Journal of Neural Transmission, 70, pp. 90-116
  • Hilakivi, Stenberg, Sinclair, Kiianmaa, Neonatal desipramine or zimeldine treatment causes long-lasting changes in brain monoaminergic systems and alcohol related behavior in rats (1987) Psychopharmacology (Berlin), 91, pp. 403-409
  • Hilakivi, Taira, Hilakivi, Loikas, Neonatal treatment with monoamine uptake inhibitors alters later response in behavioral “despair” test to beta and GABA-B receptor agonists (1988) Pharmacol. Toxicol., 63, pp. 57-61
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  • O'Sullivan, Depression and its treatment in alcoholics: a review (1984) Can. J. Psychiatry, 29, pp. 379-384
  • Porsolt, Deniel, Jalfre, Immobility induced by forced swimming in rats: effects of agents which modify central catecholamine and serotonin activity (1979) Eur. J. Pharmacol., 57, pp. 431-436
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Citas:

---------- APA ----------
Fernandez-Pardal, J. & Hilakivi, L.A. (1989) . Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs. Alcohol, 6(2), 93-95.
http://dx.doi.org/10.1016/0741-8329(89)90031-1
---------- CHICAGO ----------
Fernandez-Pardal, J., Hilakivi, L.A. "Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs" . Alcohol 6, no. 2 (1989) : 93-95.
http://dx.doi.org/10.1016/0741-8329(89)90031-1
---------- MLA ----------
Fernandez-Pardal, J., Hilakivi, L.A. "Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs" . Alcohol, vol. 6, no. 2, 1989, pp. 93-95.
http://dx.doi.org/10.1016/0741-8329(89)90031-1
---------- VANCOUVER ----------
Fernandez-Pardal, J., Hilakivi, L.A. Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs. Alcohol. 1989;6(2):93-95.
http://dx.doi.org/10.1016/0741-8329(89)90031-1