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Abstract:

The effect of disulfiram and S-adenosyl-L-methionine (SAM) administration to acute ethanol intoxicated mice on the hepatic glutathione (GSH) concentration and aminolevulinic and dehydratase (ALA-D) activity was investigated. It was found that both GSH levels and ALA-D activity were decreased, and evidence suggested that the toxic action of ethanol was due to its conversion into acetaldehyde. Administration of SAM reverses the effects of acute alcohol abuse by increasing liver GSH availability. In vitro, hepatic ALA-D activity was not modified by ethanol; instead it was non-competitively inhibited by acetaldehyde. This inhibition was efficiently reversed by GSH and cysteine (CySH). Therefore, a mechanism for the action of ethanol on ALA-D, based on the inhibitory effect of acetaldehyde, is proposed. © 1987.

Registro:

Documento: Artículo
Título:S-Adenosyl-L-methionine: Its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication
Autor:Paredes, S.R.; Kozicki, P.A.; Fukuda, H.; Rossetti, M.V.; del C. Batlle, A.M.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP) Ciudad Universitaria, Pab. II- 1428 Buenos Aires, Argentina
Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) Ciudad Universitaria, Pab. II- 1428 Buenos Aires, Argentina
Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEN), UBA Ciudad Universitaria, Pab. II, 1428 Buenos Aires, Argentina
Palabras clave:Acetaldehyde; Alcohol; Glutathione; S-Adenosyl-L-methionine; δ-Aminolevulinic acid dehydratase; alcohol; glutathione; porphobilinogen synthase; s adenosylmethionine; animal experiment; drug interaction; drug toxicity; intoxication; intraperitoneal drug administration; liver; liver toxicity; mouse; nonhuman; Acetaldehyde; Alcoholic Intoxication; Animals; Disease Models, Animal; Disulfiram; Erythrocytes; Glutathione; Liver; Male; Mice; Porphobilinogen Synthase; S-Adenosylmethionine; Animalia
Año:1987
Volumen:4
Número:2
Página de inicio:81
Página de fin:85
DOI: http://dx.doi.org/10.1016/0741-8329(87)90003-6
Título revista:Alcohol
Título revista abreviado:Alcohol
ISSN:07418329
CODEN:ALCOE
CAS:alcohol, 64-17-5; glutathione, 70-18-8; porphobilinogen synthase, 9036-37-7; s adenosylmethionine, 29908-03-0, 485-80-3; Acetaldehyde, 75-07-0; Disulfiram, 97-77-8; Glutathione, 70-18-8; Porphobilinogen Synthase, 4.2.1.24; S-Adenosylmethionine, 29908-03-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07418329_v4_n2_p81_Paredes

Referencias:

  • Batlle, Ferramola, Grinstein, Purification and general properties of delta aminolaevulinic acid dehydratase from cow liver (1967) Biochem J, 104, pp. 244-249
  • Batlle, Wider de Xifra, Stella, Bustos, With, Studies on porphyrin biosynthesis and the enzymes involved in bovine congenital erythropoietic porphyria (1979) Clin Sci (Lond), 57, pp. 63-70
  • Batlle, Bustos, Stella, Wider, Conti, Méndez, Enzyme replacement therapy in porphyrias IV First successful human trial of δ-aminolevulinate dehydratase loaded erythrocyte ghosts (1983) International Journal of Biochemistry, 15, pp. 1261-1265
  • Casgiarri, Tofanetti, Longoni, Rossini, Cova, Blood levels of ethanol and acetaldehyde following ethanol ingestion in rats: effect of glutathione (1986) IRCS Med Sci, 14, pp. 158-159
  • Di Padova, Tritapepe, Rovagnati, Pozzoli, Stramentinoli, Decreased blood levels of ethanol and acetaldehyde by S-adenosyl-L-methionine in humans (1984) Arch Toxicol [Suppl], 7, pp. 240-242
  • Erwin, Dietrich, Brain aldehyde dehydrogenase. Localization, purification and properties (1966) J Biol Chem, 241, pp. 3533-3539
  • Franke, Fikentscher, Die Bedeutung der quantitativen Porphyrin Bestimmung mix der Lumineszenzmessung für die prüfung der Leberfunktion und für Ernahrungsfrogen (1935) Münchener Medizinische Wochenschrift, 82, pp. 171-172
  • Giulidori, Galli-Kienle, Catto, Stramentinoli, Transmethylation, transsulfuration and aminopropylation reactions of S-adenosyl-L-methionine in vivo (1984) J Biol Chem, 259, pp. 4205-4211
  • Guerri, Grisolía, Hepatic GSH levels in chronicethanol treated rats (1978) Fed Proc Fed Am Soc Exp Biol, 37, p. 1491. , Third Edition
  • Kawata, Susuki, Relation between metal and glutathion concentrations in mouse liver after cadmium, zinc or copper loading (1983) Toxicol Lett, 15, pp. 131-137
  • McCall, Goldberg, Abnormal porphyrin metabolism in diseases other than porphyria (1980) The Porphyrias, 9, pp. 427-444. , Third Edition, A. Goldberg, M.R. Moore, Clinics in Haematology, W. B. Saunders Co., Ltd, London
  • McCall, Moore, Thompson, Goldberg, Abnormal haem biosynthesis in chronic alcoholics (1981) European Journal of Clinical Investigation, 2, pp. 461-468
  • McDonald, Dow, Moore, A possible protective role for sulphydryl compounds in acute alcoholic liver injury (1977) Biochemical Pharmacology, 26, pp. 1529-1531
  • Marver, Schmid, The porphyrias (1972) The Metabolic Basis of Inherited Disease, pp. 1087-1140. , J.B. Stanbury, J.B. Wyngaarden, D.S. Fredickson, McGraw-Hill, New York
  • Moore, Beattie, Thompson, Goldberg, Depression of δ-aminolaevulic acid dehydratase activity by ethanol in man and rat (1971) Clin Sci, 40, pp. 81-88
  • Paredes, Juknat de Geralnik, del C. Batlle, Conti, Beneficial effects of S-adenosyl-L-methionine in lead intoxication. Another approach to clinical therapy (1985) Int J Biochem, 17, pp. 625-629
  • Paredes, Kozicki, del C. Batlle, S-Adenosyl-L-methionine. A counter to lead intoxication? (1985) Comp Biochem Physiol [B], 82, pp. 751-757
  • Pascale, García, Daino, Frassetto, Ruggin, Pirisi, Stramentinoli, Feo, The role of S-adenosyl-methionine in the regulation of glutathione pool and acetaldehyde production in acute ethanol intoxication (1984) Res Commun Subst Abuse, 5, pp. 321-324
  • Speisky, MacDonald, Giles, Orrego, Israel, Increased loss and decreased synthesis of hepatic glutathione after acute ethanol administration (1985) Biochem J, 225, pp. 565-572
  • Viña, Estrella, Guerri, Romero, Effect of ethanol on glutathione concentration in isolated hepatocytes (1980) Biochem J, 188, pp. 549-552

Citas:

---------- APA ----------
Paredes, S.R., Kozicki, P.A., Fukuda, H., Rossetti, M.V. & del C. Batlle, A.M. (1987) . S-Adenosyl-L-methionine: Its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication. Alcohol, 4(2), 81-85.
http://dx.doi.org/10.1016/0741-8329(87)90003-6
---------- CHICAGO ----------
Paredes, S.R., Kozicki, P.A., Fukuda, H., Rossetti, M.V., del C. Batlle, A.M. "S-Adenosyl-L-methionine: Its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication" . Alcohol 4, no. 2 (1987) : 81-85.
http://dx.doi.org/10.1016/0741-8329(87)90003-6
---------- MLA ----------
Paredes, S.R., Kozicki, P.A., Fukuda, H., Rossetti, M.V., del C. Batlle, A.M. "S-Adenosyl-L-methionine: Its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication" . Alcohol, vol. 4, no. 2, 1987, pp. 81-85.
http://dx.doi.org/10.1016/0741-8329(87)90003-6
---------- VANCOUVER ----------
Paredes, S.R., Kozicki, P.A., Fukuda, H., Rossetti, M.V., del C. Batlle, A.M. S-Adenosyl-L-methionine: Its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication. Alcohol. 1987;4(2):81-85.
http://dx.doi.org/10.1016/0741-8329(87)90003-6