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Abstract:

Motor activity induced in the Circling Training test (CT) during a postnatal (PN) critical period of plasticity (PN30-37) produces a long-lasting decrease in the number of binding sites and mRNA expression levels of the dopamine D2 receptor (D2R) in rat striatum. Prenatal exposure to the antipsychotic haloperidol also decreases postnatal levels of the striatal D2R in the offspring. We examined whether such fetal exposure to haloperidol could affect the activity-dependent reduction of the D2R system during the critical period. Half of the male offspring exposed to either haloperidol (2.5. mg/kg/day), i.p.) or saline during gestational days 5-18 were subjected to the CT during the critical period, while the remaining represented CT control animals. The adult number of binding sites and mRNA expression levels of the striatal D2R at PN90 were not changed by prenatal haloperidol treatment alone. On the other hand, only pups subjected to the CT during the critical period showed decreases in both studied parameters, regardless the prenatal treatment. These findings indicated that the postnatal reduction of the striatal D2R binding induced prenatally by haloperidol does not affect long-lasting activity-dependent plastic changes on the same receptor system elicited by motor activity in an ontogenetic critical period of plasticity in rat striatum. © 2011 ISDN.

Registro:

Documento: Artículo
Título:Activity-dependent reduction of dopamine D2 receptors during a postnatal critical period of plasticity in rat striatum is not affected by prenatal haloperidol treatment
Autor:Soiza-Reilly, M.; Azcurra, J.M.
Filiación:Laboratorio de Biología Celular, Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160, C1428EGA, Buenos Aires, Argentina
Palabras clave:Critical period of plasticity; Development; Dopamine D2 receptor; Haloperidol; Motor behavior; Striatum; dopamine 2 receptor; haloperidol; messenger RNA; sodium chloride; adulthood; animal experiment; animal tissue; article; binding site; controlled study; corpus striatum; female; gene expression; gestation period; instrumental conditioning; learning; male; motor activity; nerve cell plasticity; nonhuman; ontogeny; perinatal period; prenatal drug exposure; priority journal; progeny; pup (rodent); rat; receptor binding; Animals; Behavior, Animal; Binding Sites; Corpus Striatum; Dopamine; Dopamine Antagonists; Female; Fetus; Gestational Age; Haloperidol; Humans; Male; Motor Activity; Neuronal Plasticity; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; RNA, Messenger; Animalia; Rattus
Año:2011
Volumen:29
Número:8
Página de inicio:855
Página de fin:860
DOI: http://dx.doi.org/10.1016/j.ijdevneu.2011.08.001
Título revista:International Journal of Developmental Neuroscience
Título revista abreviado:Int. J. Dev. Neurosci.
ISSN:07365748
CODEN:IJDND
CAS:haloperidol, 52-86-8; sodium chloride, 7647-14-5; Dopamine Antagonists; Haloperidol, 52-86-8; RNA, Messenger; Receptors, Dopamine D2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07365748_v29_n8_p855_SoizaReilly

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Citas:

---------- APA ----------
Soiza-Reilly, M. & Azcurra, J.M. (2011) . Activity-dependent reduction of dopamine D2 receptors during a postnatal critical period of plasticity in rat striatum is not affected by prenatal haloperidol treatment. International Journal of Developmental Neuroscience, 29(8), 855-860.
http://dx.doi.org/10.1016/j.ijdevneu.2011.08.001
---------- CHICAGO ----------
Soiza-Reilly, M., Azcurra, J.M. "Activity-dependent reduction of dopamine D2 receptors during a postnatal critical period of plasticity in rat striatum is not affected by prenatal haloperidol treatment" . International Journal of Developmental Neuroscience 29, no. 8 (2011) : 855-860.
http://dx.doi.org/10.1016/j.ijdevneu.2011.08.001
---------- MLA ----------
Soiza-Reilly, M., Azcurra, J.M. "Activity-dependent reduction of dopamine D2 receptors during a postnatal critical period of plasticity in rat striatum is not affected by prenatal haloperidol treatment" . International Journal of Developmental Neuroscience, vol. 29, no. 8, 2011, pp. 855-860.
http://dx.doi.org/10.1016/j.ijdevneu.2011.08.001
---------- VANCOUVER ----------
Soiza-Reilly, M., Azcurra, J.M. Activity-dependent reduction of dopamine D2 receptors during a postnatal critical period of plasticity in rat striatum is not affected by prenatal haloperidol treatment. Int. J. Dev. Neurosci. 2011;29(8):855-860.
http://dx.doi.org/10.1016/j.ijdevneu.2011.08.001