Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

We investigated the expression of transforming growth factors β1 and α (TGF-β1, TGF-α in hormone-responsive (MPA-R) and unresponsive (MPA-U) tumor lines obtained from medroxyprogesterone acetate (MPA)-induced mammary adenocarcinomas in BALBIc mice. The tumors were transplanted into MPA-treated and untreated mice. TGF-β1 gene expression was observed in the MPA-R lines growing in untreated animals, but not in MPA-treated mice. TGF-β1 mRNA was not detected in the MPA-U tumor lines growing in either MPA-treated or untreated animals. In MPA-R lines the levels of TGF-β1 expression were inversely correlated to growth rate. High-affinity TGF-β1 receptors were present in the MPA-R tumors. These results suggest that one of the mechanisms by which MP A exerts its proliferative effect on MPA-R tumor lines is inhibition of the expression of TGF-β1. Thus, the lack of expression of TGF-β1 in MPA-U tumors may be related to the acquisition of autonomous growth. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Registro:

Documento: Artículo
Título:Correlation of TGF-(si expression with medroxiprogesterone acetate responsiveness in mouse mammary adenocarcinomas
Autor:Elizalde, P.V.; Guerra, F.K.; Gravano, M.; Lanari, C.; Lippman, M.E.; Charreau, E.H.; Lupu, R.
Filiación:Instituto de Biologfa y Medicina Experimental (IBYME), Obligado 2490, Buenos Aires, 1428, Argentina
Instituto de Investigaciones Hematologicas Academia Nacional de Medicina, J A Pacheco de Melo 3081, Buenos Aires, 1425, Argentina
Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, 3800 Reservoir Road NW, WA, DC, 20007, United States
Palabras clave:medroxyprogesterone acetate; transforming growth factor beta1; animal experiment; animal model; article; breast carcinoma; controlled study; female; mouse; nonhuman; priority journal; Adenocarcinoma; Animal; Female; Gene Expression; Mammary Neoplasms, Experimental; Medroxyprogesterone 17-Acetate; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Receptors, Estrogen; Receptors, Progesterone; Receptors, Transforming Growth Factor beta; RNA, Messenger; RNA, Neoplasm; Support, Non-U.S. Gov't; Transforming Growth Factor alpha; Transforming Growth Factor beta; Tumor Cells, Cultured
Año:1995
Volumen:13
Número:2
Página de inicio:173
Página de fin:180
DOI: http://dx.doi.org/10.3109/07357909509011687
Título revista:Cancer Investigation
Título revista abreviado:Cancer Invest.
ISSN:07357907
CODEN:CINVD
CAS:medroxyprogesterone acetate, 71-58-9; Medroxyprogesterone 17-Acetate, 71-58-9; Receptors, Estrogen; Receptors, Progesterone; Receptors, Transforming Growth Factor beta; RNA, Messenger; RNA, Neoplasm; Transforming Growth Factor alpha; Transforming Growth Factor beta
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07357907_v13_n2_p173_Elizalde

Referencias:

  • Lippman, M.E., Dickson, R.B., Mechanisms of normal and malignant breast epithelial growth regulation (1989) J Steroid Biochem, 34, pp. 107-121
  • Lippman, M.E., Dickson, R.B., Mechanisms of growth control in normal and malignant breast epithelium (1989) Recent Progress in Hormone Research, pp. 383-440. , Ed. J H Clark. Academic Press,New York
  • Cullen, K.J., Lippman, M.E., Estrogen regulation of protein synthesis and cell growth in human breast cancer (1989) Vitamins and Hormones, pp. 127-172. , Eds. G D Aurbach, D B McCormick. Academic Press,New York
  • Bergkvist, L., Adami, H.-O., Persson, I., The risk of breast cancer after estrogen and estrogen-progestin replacement (1989) N Engl J Med, 321, pp. 293-297
  • Murphy, L.C., Dotzlaw, H., Regulation of transforming growth factor α and transforming growth factor β messenger ribonucleic acid abundance in T-47D. human breast cancer cells (1989) Mol Endocrinol, 3, pp. 611-617
  • Lanari, C., Molinolo, A.A., Dosne Pasqualini, C., Induction of mammary adenocarcinomas by medroxyprogesterone acetate in BALB/c female mice (1986) Cancer Lett, 33, pp. 215-223
  • Molinolo, A.A., Lanari, C., Charreau, E.H., Mouse mammary tumors induced by medroxyprogesterone acetate: lm-munochemistry and hormonal receptors (1987) J Natl Cancer Inst, 79, pp. 1341-1350
  • Lanari, C., Kordon, E., Molinolo, A.A., Mammary adenocarcinomas induced by medroxyprogesterone acetate: Hormone dependence and EOF receptors of BALB/c in vivo sublines (1989) Int J Cancer, 43, pp. 845-850
  • Elizalde, P.V., Lanari, C., Kordon, E., Transforming growth factor-β activities in “in vivo” lines of hormone-dependent and independent mammary adenocarcinomas induced by medroxyprogesterone acetate in BALB/c mice (1990) Breast Cancer Res Treat, 16, pp. 29-39
  • Miller, D.A., Pelton, R.W., Derynk, R., Transforming growth factor-0: A family of growth regulatory peptides (1990) Ann NY Acad Sci, 593, pp. 208-217
  • Roberts, A.B., Sporn, M.B., The transforming growth factors (1990) Handbook of Experimental Pharmacology, pp. 419-472. , Eds. M B Sporn, A B Roberts. Springer-Verlag,Heidelberg
  • Bascom, C.C., Sipes, N.J., Coffey, R.J., Regulation of cell proliferation by transforming growth factors (1989) J Cell Biochem, 39, pp. 25-32
  • Lyons, R.M., Moses, H.L., Transforming growth factors and the regulation of cell proliferation (1990) Eur J Biochem, 187, pp. 467-473
  • Bronzert, D.A., Bates, S.E., Sheridan, L.P., Transforming growth factor-β induces platelet derived growth factor (PDGF) messenger RNA and PDGF secretion while inhibiting growth in normal human mammary epithelial cells (1990) Mol Endocrinol, 4, pp. 981-989
  • Valverius, E.M., Walker-Jones, D., Bates, S.E., Production and responsiveness to transforming growth factor-β in normal and oncogene-transformed human mammary epithelial cells (1989) Cancer Res, 49, pp. 6269-6274
  • Zugmaier, G., Ennis, B.W., Deschauer, B., Transforming growth factors type β1 and β2 are equipotent growth inhibitors of human breast cancer cell lines (1989) J Cell Physiol, 141, pp. 353-361
  • Heifetz, S., Weatherbee, J.A., Tsang, M.L.-S., The transforming growth-β-system, a complex pattern of cross reactive ligands and receptors (1987) Cell, 48, pp. 409-415
  • Cheifetz, S., Massague, J., The TGF-β receptor proteoglycan. Cell surface expression and ligand in the absence of glyco-saminoglycan chains (1989) J Biol Chem, 264, pp. 12025-12028
  • Cheifetz, S., Ling, N., Guillemin, R., A surface component on GH3 pituitary cells that recognizes transforming growth factor-0, activin, and inhibin (1989) J Biol Chem, 263, pp. 17225-17228
  • O'Grady, P., Kuo, M.-D., Baldassare, J.J., Purification of a new type of high molecular weight receptor (type V receptor) of transforming growth factor β(TGF-β) from bovine liver (1991) J Biol Chem, 266, pp. 8583-8589
  • Boyd, F.T., Massagué, J., Transforming growth factor /3 inhibition of epithelial cell proliferation linked to the expression of a 53 kDa membrane receptor (1989) J Biol Chem, 264, pp. 2272-2278
  • Clarke, R., Brunner, N., Katz, D., The effects of a constitutive expression of transforming growth factor-a on the growth of MCF-7 human breast cancer cells in vitro and in vivo (1989) Mol Endocrinol, 3, pp. 372-380
  • Chirgwin, J., Pryzbyla, A., McDonald, R., Isolation of biologically active ribonucleic acid from sources enriched for ribonuclease (1979) Biochemistry, 18, pp. 5294-5298
  • Frolik, C.A., Wakefield, L.M., Smith, D.M., Characterization of a membrane receptor for transforming growth factor-j3 in normal rat kidney fibroblasts (1984) J Biol Chem, 259, pp. 10995-11000
  • Massagué, J., Like, B., Cellular receptors for type βtransforming growth factor (1985) J Biol Chem, 260, pp. 2636-2645
  • Scatchard, G., The attraction of proteins from small molecules and ions (1949) Ann NY Acad Sci, 51, pp. 660-672
  • Knabbe, C., Lippman, M.E., Wakefield, L.M., Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells (1987) Cell, 48, pp. 417-428
  • Arteaga, C.L., Tandom, A.K., Von Hoff, D.D., Transforming growth factor β: Potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells (1988) Cancer Res, 48, pp. 3898-3904
  • Clarke, C.L., Sutherland, R.L., Progestin regulation of cellular proliferation (1990) Endocrinol Rev, 11, pp. 266-301
  • Colletta, A.A., Wakefield, L.M., Howell, F.V., The growth inhibition of human breast cancer cells by a novel synthetic progestin involves the induction of transforming growth factor /3 (1991) J Clin Invest, 87, pp. 277-283
  • Jeng, M.-H., Jordan, V.C., Growth stimulation and differential regulationof transforming growth factor-β1 (TGF-β1) TGF-β2 and TGFβ3 messenger RNA levels by norethindrone in MCF-7 human breast cancer cells (1991) Mol Endocrinol, 5, pp. 1120-1128
  • Arryck, B.A., Korc, M., Derynk, R., Differential regulation of expression of three transforming growth factor-β species in human breast cancer cell lines by estradiol (1990) Cancer Res, 50, pp. 299-303
  • Dickson, R.B., Huff, K.K., Spencer, E.M., Induction of epidermal growth factor-related polypeptides by 17β-estradiol in MCF-7 cells (1986) Endocrinology, 188, pp. 138-142
  • Valverius, E.M., Bates, S.E., Stampfer, M.R., Transforming growth factor α production and epidermal growth factor receptor expression in normal and oncogene transformed human mammary epithelial cells (1989) Mol Endocrinol, 3, pp. 203-214
  • Derynk, R., Goeddel, D.V., Ullrich, A., Synthesis of messenger RNAs for transforming growth factors α and β and the epidermal growth factor receptor by human tumors (1987) Cancer Res, 47, pp. 707-712
  • Bates, S.E., Davidson, S.E., Valverius, E.M., Expression of transforming growth factor alpha and its mRNA in human breast cancer: Its regulation by estrogen and its possible functional significance (1988) Mol Endocrinol, 2, pp. 543-555
  • Dickson, R.B., McManaway, M.E., Lippman, M.E., Estrogen-induced factors of breast cancer cells partially replace estrogen to promote tumor growth (1986) Science, 232, pp. 1540-1543
  • Salomon, D.S., Perroteau, I., Kidwell, W.R., Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha-transforming growth factors in ras transformed mouse mammary epithelial cells (1987) J Cell Physiol, 130, pp. 397-409
  • Liu, S.C., Sannfilippo, B., Perroteau, I., Expression of transforming growth factor α (TGF-α) in differentiated rat mammary tumors: Estrogen induction of TGF production (1987) Mol Endocrinol, 1, pp. 683-692
  • Ciardiello, F., Kim, N., Liscia, D.S., mRNA expression of transforming growth factor alpha in human breast carcinomas and its activity in effusions of breast cancer patients (1989) J Natl Cancer Inst, 81, pp. 1165-1171
  • Murphy, L.C., Dotzlaw, H., Endogenous growth factor expression in T-47D. human breast cancer cells, associated with reduced sensitivity to antiproliferative effects of progestins and anti-estrogens (1989) Cance Res, 49, pp. 599-604
  • Sutherland, R.L., Lee, C.S.L., Healey, P.R.J., Progestin and glucocorticoid regulation of epidermal growth factor receptor and alpha transforming growth factor gene expression in human breast cancer cells (1989) Am Assoc Cancer Res, 30, p. 261. , (abstract)

Citas:

---------- APA ----------
Elizalde, P.V., Guerra, F.K., Gravano, M., Lanari, C., Lippman, M.E., Charreau, E.H. & Lupu, R. (1995) . Correlation of TGF-(si expression with medroxiprogesterone acetate responsiveness in mouse mammary adenocarcinomas. Cancer Investigation, 13(2), 173-180.
http://dx.doi.org/10.3109/07357909509011687
---------- CHICAGO ----------
Elizalde, P.V., Guerra, F.K., Gravano, M., Lanari, C., Lippman, M.E., Charreau, E.H., et al. "Correlation of TGF-(si expression with medroxiprogesterone acetate responsiveness in mouse mammary adenocarcinomas" . Cancer Investigation 13, no. 2 (1995) : 173-180.
http://dx.doi.org/10.3109/07357909509011687
---------- MLA ----------
Elizalde, P.V., Guerra, F.K., Gravano, M., Lanari, C., Lippman, M.E., Charreau, E.H., et al. "Correlation of TGF-(si expression with medroxiprogesterone acetate responsiveness in mouse mammary adenocarcinomas" . Cancer Investigation, vol. 13, no. 2, 1995, pp. 173-180.
http://dx.doi.org/10.3109/07357909509011687
---------- VANCOUVER ----------
Elizalde, P.V., Guerra, F.K., Gravano, M., Lanari, C., Lippman, M.E., Charreau, E.H., et al. Correlation of TGF-(si expression with medroxiprogesterone acetate responsiveness in mouse mammary adenocarcinomas. Cancer Invest. 1995;13(2):173-180.
http://dx.doi.org/10.3109/07357909509011687