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Abstract:

Cultured splenic mononuclear adherent cells (SMAc) from normal BALB/c mice as well as those from mice bearing 10-day sarcoma 180 (S180), exhibited a marked increase in Escherichia coli lipopolysaccharide-stimulated interleukin-1 (IL-1) production, when compared to spontaneous values. On days 20 and 30 following S180 challenge, a decrease in this effect on IL-1 production in treated and untreated SMAc was observed. Concomitantly with the alterations in the regulation of IL-1 production during tumor growth, an increase in the levels of prostaglandin E2 and serum immune complexes could be detected. These data suggest that the immunosuppression associated with later stages of tumor development may be due to direct effects on monocytes, by means of a down-regulation of IL-1 production. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Registro:

Documento: Artículo
Título:Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes
Autor:Chasseing, N.A.; Eugui, E.M.; Borda, E.S.; Rumi, L.
Filiación:Instituto de Biologia y Medicina Experimental Obligado, 2490 1428, Buenos Aires, Argentina
Institute of Biological Sciences Syntex Research, 3401 Hillview Avenue, Palo Alto, CA, 94304, United States
Centro de Estudios Farmacológicos y Botánicos (CEFYBO) Serrano, 665, Buenos Aires, Argentina
Palabras clave:escherichia coli lipopolysaccharide; interleukin 1; prostaglandin e2; animal cell; animal experiment; animal model; antigen antibody complex; article; cancer growth; carcinogenesis; controlled study; female; host resistance; immunomodulation; mononuclear cell; mouse; nonhuman; priority journal; sarcoma cell; tumor immunity; Animal; Antigen-Antibody Complex; Cell Adhesion; Cell Division; Dinoprostone; Escherichia coli; Evaluation Studies; Female; Interleukin-1; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Monocytes; Neoplasm Transplantation; Sarcoma 180; Spleen; Support, Non-U.S. Gov't
Año:1994
Volumen:12
Número:4
Página de inicio:390
Página de fin:394
DOI: http://dx.doi.org/10.3109/07357909409038228
Título revista:Cancer Investigation
Título revista abreviado:Cancer Invest.
ISSN:07357907
CODEN:CINVD
CAS:prostaglandin E2, 363-24-6; Antigen-Antibody Complex; Dinoprostone, 363-24-6; Interleukin-1; Lipopolysaccharides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07357907_v12_n4_p390_Chasseing

Referencias:

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Citas:

---------- APA ----------
Chasseing, N.A., Eugui, E.M., Borda, E.S. & Rumi, L. (1994) . Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes. Cancer Investigation, 12(4), 390-394.
http://dx.doi.org/10.3109/07357909409038228
---------- CHICAGO ----------
Chasseing, N.A., Eugui, E.M., Borda, E.S., Rumi, L. "Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes" . Cancer Investigation 12, no. 4 (1994) : 390-394.
http://dx.doi.org/10.3109/07357909409038228
---------- MLA ----------
Chasseing, N.A., Eugui, E.M., Borda, E.S., Rumi, L. "Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes" . Cancer Investigation, vol. 12, no. 4, 1994, pp. 390-394.
http://dx.doi.org/10.3109/07357909409038228
---------- VANCOUVER ----------
Chasseing, N.A., Eugui, E.M., Borda, E.S., Rumi, L. Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes. Cancer Invest. 1994;12(4):390-394.
http://dx.doi.org/10.3109/07357909409038228