Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

When a passing shadow is presented to the crab (Chasmagnathus granulatus), an escape response is elicited that habituates after repeated stimulation. Results of previous papers suggest that this habituation might be mediated by endogenous opiates, entailing the postulate that opiates may inhibit the response to a danger stimulus. This contention is tested herein. Two trials (T1, T2) of shadow stimulation were given 30 min apart, and the response activity was recorded. In Experiment 1 a range of morphine doses (0, 25, 50, 75, and 100 μg/g) were injected into crabs immediately after T1. Analysis of the M response values showed a morphine dose-dependent reduction in the crab's reactivity to the danger stimulus in T2. In Experiment 2, groups of crabs were injected with 1 of 4 solutions: saline, 70 μg/g morphine, 70 μg/g, morphine plus 1.6 μg/g naloxone, or 1.6 μg/g naloxone. Results suggest that morphine acts through an opiate receptor to inhibit the crab's response level to a danger stimulus. Three possible mechanisms of the morphine effect are discussed, and the most viable one suggests a central site of action.

Registro:

Documento: Artículo
Título:Opioid Action on Response Level to a Danger Stimulus in the Crab (Chasmagnathus granulatus)
Autor:Maldonado, H.; Romano, A.; Lozada, M.
Filiación:Laboratorio de Fisiología del Comportamiento Animal, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:morphine; naloxone; opiate receptor; animal experiment; arthropod; crab; escape behavior; nonhuman; psychological aspect; Animal; Arousal; Brachyura; Dose-Response Relationship, Drug; Escape Reaction; Male; Morphine; Reaction Time; Receptors, Opioid; Support, Non-U.S. Gov't
Año:1989
Volumen:103
Número:5
Página de inicio:1139
Página de fin:1143
DOI: http://dx.doi.org/10.1037/0735-7044.103.5.1139
Título revista:Behavioral Neuroscience
Título revista abreviado:Behav. Neurosci.
ISSN:07357044
CODEN:BENED
CAS:morphine, 52-26-6, 57-27-2; naloxone, 357-08-4, 465-65-6; Morphine, 57-27-2; Receptors, Opioid
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07357044_v103_n5_p1139_Maldonado

Referencias:

  • Bodnar, R.J., Types of stress which induce analgesia (1984) Stress-induced analgesia, pp. 19-32. , Tricklebank M.D., and Curzon G. (Eds), Wiley, New York
  • Brunner, D., Maldonado, H., Habituation in the crab Chasmagnathus granulatus: Effect of morphine and naloxone (1988) Journal of Comparative Physiology, 162, pp. 687-694
  • Davenport, A.P., Evans, P.D., Sex-related differences in the concentration of Met-enkephalin-like immunoreactivity in the nervous system of an insect Schistocerca gregaria, revealed by radioimmunoassay (1986) Brain Research, 383, pp. 319-322
  • Davis, M., Morphine and naloxone: Effects on conditioned fear as measured with the potentiated startle paradigm (1979) European Journal of Pharmacology, 54, pp. 341-347
  • Fanselow, M.S., Opiate modulation of the active and inactive components of the postshock reaction: Parallels between naloxone pretreatment and shock intensity (1984) Behavioral Neuroscience, 98, pp. 269-277
  • Fanselow, M.S., Odors released by stressed rats produce opioid analgesia in unstressed rats (1985) Behavioral Neuroscience, 99, pp. 589-592
  • Fanselow, M.S., Conditioned fear-induced opiate analgesia: A competing motivational state theory of stress analgesia (1986) Stress-induced analgesia, pp. 40-54. , Kelly D.D. (Ed), New York Academy of Sciences, New York
  • Hentschel, E., Penzlin, H., Beeinflussung des Putzverhal-tens bei Periplaneta americana (L) durch Wundsetzung, Naloxon-, Morphin- und Met-Enkephalingaben [Influence of lesion or naloxone, morphine and Met-enkephalin injections on breeding behavior in Periplaneta americana.] (1982) Zoologische Jahrbuecher Physiologie, 86, pp. 361-370
  • Izquierdo, I., Netto, C.A., The role of β-endorphin in memory regulation (1985) Annals of the New York Academy of Sciences, 444, pp. 162-167
  • Izquierdo, I., Souza, D.O., Dias, R.D., Carrasco, M.A., Volkmer, N., Perry, M.L.S., Netto, C.A., Effect of various behavioral training and testing procedures on brain β-endorphin-like immunoreactivity, and the possible role of β-endorphin in behavioral regulation (1984) Psychoneuroendocrinology, 9, pp. 381-389
  • Jensen, T.S., Smith, D.F., Effect of emotions on nociceptive thresholds in rats (1982) Physiology and Behavior, 28, pp. 597-599
  • Kavaliers, M., Guglick, M.A., Hirst, M., Opioid involvement in the control of feeding in an insect, the American cockroach (1987) Life Sciences, 40, pp. 665-672
  • Krasne, B.F., Learning in crustacea (1972) Invertebrate learning, 2, pp. 49-130. , Coming W., Dyal J., and Willows A.O.D. (Eds), Plenum Press, New York
  • Lester, L.S., Fanselow, M.S., Exposure to a cat produces opioid analgesia in rats (1985) Behavioral Neuroscience, 99, pp. 756-759
  • Lozada, M., Romano, A., Maldonado, H., Effect of morphine and naloxone on a defensive response of the crab Chasmagnathus granulatus (1988) Pharmacology Biochemistry and Behavior, 30, pp. 635-640
  • Maldonado, H., Miralto, A., Effect of morphine and naloxone on a defensive response of the mantis shrimp (Squilla mantis) (1982) Journal of Comparative Physiology, 147, pp. 455-459
  • Pages, M., Jimenez, F., Ferrus, A., Ramirez, G., Gelpi, E., Enkephalin-like immunoreactivity in Drosophila melanogaster (1983) Neuropeptides, 4, pp. 87-98
  • Romano, A., Lozada, M., Maldonado, H., Effect of naloxone pretreatment on habituation in the crab Chasmagnathus granulatus, , in press, Behavioral and Neural Biology
  • Schone, H., Agonistic and sexual display in aquatic and semi-terrestrial brachyuran crabs (1968) American Zoologist, 8, pp. 641-654
  • Siegfried, B., Netto, C.A., Izquierdo, I., Exposure to novelty induces naltrexone-reversible analgesia in rats (1987) Behavioral Neuroscience, 101, pp. 436-438
  • Tomsic, D., Maldonado, H., Opiate action on the optokinetic response in the crab Chasmagnathus granulatus (1988), Manuscript submitted for publication; Valeggia, C., Fernandez-Duque, E., Maldonado, H., Danger stimulus-induced analgesia in the crab Chasmagnathus granulatus (1989) Brain Research, 481, pp. 304-308
  • Verhaert, P., De Loof, A., Immunocytochemical localization of methionine-enkephalin-resembling neuropeptide in the central nervous system of the American cockroach, Periplaneta americana (1985) Journal of Comparative Neurology, 239, pp. 54-61
  • Warren, P.H., Ison, J.R., Selective action of morphine on reflex expression to nociceptive stimulation in the rat: A contribution to the assessment of analgesia (1982) Pharmacology Biochemistry and Behavior, 16, pp. 869-875
  • Wright, H.O., Visual displays in brachyuran crabs: Field and laboratory studies (1968) American Zoologist, 8, pp. 655-665
  • Zabala, N.A., Miralto, A., Maldonado, H., Nunez, J.A., Jaffe, K., Calderon, L.d.C., Opiate receptor in praying mantis: Effect of morphine and naloxone (1984) Pharmacology Biochemistry and Behavior, 20, pp. 683-687

Citas:

---------- APA ----------
Maldonado, H., Romano, A. & Lozada, M. (1989) . Opioid Action on Response Level to a Danger Stimulus in the Crab (Chasmagnathus granulatus). Behavioral Neuroscience, 103(5), 1139-1143.
http://dx.doi.org/10.1037/0735-7044.103.5.1139
---------- CHICAGO ----------
Maldonado, H., Romano, A., Lozada, M. "Opioid Action on Response Level to a Danger Stimulus in the Crab (Chasmagnathus granulatus)" . Behavioral Neuroscience 103, no. 5 (1989) : 1139-1143.
http://dx.doi.org/10.1037/0735-7044.103.5.1139
---------- MLA ----------
Maldonado, H., Romano, A., Lozada, M. "Opioid Action on Response Level to a Danger Stimulus in the Crab (Chasmagnathus granulatus)" . Behavioral Neuroscience, vol. 103, no. 5, 1989, pp. 1139-1143.
http://dx.doi.org/10.1037/0735-7044.103.5.1139
---------- VANCOUVER ----------
Maldonado, H., Romano, A., Lozada, M. Opioid Action on Response Level to a Danger Stimulus in the Crab (Chasmagnathus granulatus). Behav. Neurosci. 1989;103(5):1139-1143.
http://dx.doi.org/10.1037/0735-7044.103.5.1139