Abstract:
Purine carbanucleosides built on a 6-oxabicyclo[3.1.0]hexane template were synthesized from readily available 2-cyclopentenone employing a Mitsunobu reaction to incorporate the base onto the carbocyclic ring. Both adenosine and guanosine analogues exhibited moderate antiviral activity.
Registro:
Documento: |
Artículo
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Título: | Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C |
Autor: | Comin, M.J.; Pujol, C.A.; Damonte, E.B.; Rodriguez, J.B. |
Filiación: | Depto. de Quim. Organica, Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, RA-1428 Buenos Aires, Argentina Laboratorio de Virología, Depto. de Quim. Biologica, Ciudad Universitaria, RA-1428 Buenos Aires, Argentina
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Palabras clave: | aciclovir; adenosine derivative; guanosine derivative; purine nucleoside; animal cell; antiviral activity; article; controlled study; drug activity; drug structure; drug synthesis; Herpes simplex virus 1; Herpes simplex virus 2; human; human cell; Human cytomegalovirus; nonhuman |
Año: | 1999
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Volumen: | 18
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Número: | 10
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Página de inicio: | 2219
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Página de fin: | 2231
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DOI: |
http://dx.doi.org/10.1080/07328319908044877 |
Título revista: | Nucleosides and Nucleotides
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Título revista abreviado: | Nucleosides Nucleotides
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ISSN: | 07328311
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CODEN: | NUNUD
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CAS: | aciclovir, 59277-89-3
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07328311_v18_n10_p2219_Comin |
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Citas:
---------- APA ----------
Comin, M.J., Pujol, C.A., Damonte, E.B. & Rodriguez, J.B.
(1999)
. Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C. Nucleosides and Nucleotides, 18(10), 2219-2231.
http://dx.doi.org/10.1080/07328319908044877---------- CHICAGO ----------
Comin, M.J., Pujol, C.A., Damonte, E.B., Rodriguez, J.B.
"Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C"
. Nucleosides and Nucleotides 18, no. 10
(1999) : 2219-2231.
http://dx.doi.org/10.1080/07328319908044877---------- MLA ----------
Comin, M.J., Pujol, C.A., Damonte, E.B., Rodriguez, J.B.
"Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C"
. Nucleosides and Nucleotides, vol. 18, no. 10, 1999, pp. 2219-2231.
http://dx.doi.org/10.1080/07328319908044877---------- VANCOUVER ----------
Comin, M.J., Pujol, C.A., Damonte, E.B., Rodriguez, J.B. Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C. Nucleosides Nucleotides. 1999;18(10):2219-2231.
http://dx.doi.org/10.1080/07328319908044877