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Abstract:

Purine carbanucleosides built on a 6-oxabicyclo[3.1.0]hexane template were synthesized from readily available 2-cyclopentenone employing a Mitsunobu reaction to incorporate the base onto the carbocyclic ring. Both adenosine and guanosine analogues exhibited moderate antiviral activity.

Registro:

Documento: Artículo
Título:Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C
Autor:Comin, M.J.; Pujol, C.A.; Damonte, E.B.; Rodriguez, J.B.
Filiación:Depto. de Quim. Organica, Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, RA-1428 Buenos Aires, Argentina
Laboratorio de Virología, Depto. de Quim. Biologica, Ciudad Universitaria, RA-1428 Buenos Aires, Argentina
Palabras clave:aciclovir; adenosine derivative; guanosine derivative; purine nucleoside; animal cell; antiviral activity; article; controlled study; drug activity; drug structure; drug synthesis; Herpes simplex virus 1; Herpes simplex virus 2; human; human cell; Human cytomegalovirus; nonhuman
Año:1999
Volumen:18
Número:10
Página de inicio:2219
Página de fin:2231
DOI: http://dx.doi.org/10.1080/07328319908044877
Título revista:Nucleosides and Nucleotides
Título revista abreviado:Nucleosides Nucleotides
ISSN:07328311
CODEN:NUNUD
CAS:aciclovir, 59277-89-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07328311_v18_n10_p2219_Comin

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Citas:

---------- APA ----------
Comin, M.J., Pujol, C.A., Damonte, E.B. & Rodriguez, J.B. (1999) . Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C. Nucleosides and Nucleotides, 18(10), 2219-2231.
http://dx.doi.org/10.1080/07328319908044877
---------- CHICAGO ----------
Comin, M.J., Pujol, C.A., Damonte, E.B., Rodriguez, J.B. "Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C" . Nucleosides and Nucleotides 18, no. 10 (1999) : 2219-2231.
http://dx.doi.org/10.1080/07328319908044877
---------- MLA ----------
Comin, M.J., Pujol, C.A., Damonte, E.B., Rodriguez, J.B. "Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C" . Nucleosides and Nucleotides, vol. 18, no. 10, 1999, pp. 2219-2231.
http://dx.doi.org/10.1080/07328319908044877
---------- VANCOUVER ----------
Comin, M.J., Pujol, C.A., Damonte, E.B., Rodriguez, J.B. Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C. Nucleosides Nucleotides. 1999;18(10):2219-2231.
http://dx.doi.org/10.1080/07328319908044877