Artículo

Levy, C.S.; Slomiansky, V.; Gattelli, A.; Nahmod, K.; Pelisch, F.; Blaustein, M.; Srebrow, A.; Coso, O.A.; Kordon, E.C. "Tumor necrosis factor alpha induces LIF expression through ERK1/2 activation in mammary epithelial cells" (2010) Journal of Cellular Biochemistry. 110(4):857-865
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

It has been reported that expression of tumor necrosis factor superfamily members occur at the onset of the mammary gland post-lactational involution. One of these proteins, tumor necrosis factor alpha (TNFα), is a major mediator of inflammation that is able to induce expression of several cytokines. Leukemia inhibitory factor (LIF) is an inflammatory cytokine that is induced and plays a fundamental role during postlactational involution of the mammary gland. Therefore, our goal was to determine whether TNFα activity in the mammary epithelium might include regulation of LIF expression. This biological role would increase the significance of TNFα expression at the end of lactation. Our results show that TNFα was able to induce LIF transcription through ERK1/2 activation in a non-tumorigenic mouse mammary epithelial cell line, SCp2. We found that activation of TNFα receptor-2 (TNFR2) was specifically involved in triggering this signaling pathway. In addition, our data suggest the participation of AP-1 transcription factor family members in this pathway. We determined that TNFα treatment induced c-fos transcription, and blocking AP-1 activity resulted in a significant inhibition of TNFα-induced LIF expression. Finally, we found that TNFα was also able to trigger LIF expression and ERK1/2 activation in the mouse mammary gland in vivo. Therefore, our data suggest that TNFα may contribute to mammary gland involution by, among other activities, eliciting LIF expression through ERK1/2 and AP1 activation. © 2010 Wiley-Liss, Inc.

Registro:

Documento: Artículo
Título:Tumor necrosis factor alpha induces LIF expression through ERK1/2 activation in mammary epithelial cells
Autor:Levy, C.S.; Slomiansky, V.; Gattelli, A.; Nahmod, K.; Pelisch, F.; Blaustein, M.; Srebrow, A.; Coso, O.A.; Kordon, E.C.
Filiación:IFIBYNE-CONICET, Facultad de Ciencias Exactas Y Naturales, UBA, (1428), Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, (C1428EHA),Buenos Aires, Argentina
Laboratorio de Inmunología, Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina
Departamento de Fisiología Y Biología Molecular, FCEN, UBA, Buenos Aires, Argentina
Palabras clave:AP-1; Involution; LIF; Mammary epithelial cells; Mammary gland; TNFα; leukemia inhibitory factor; mitogen activated protein kinase 1; mitogen activated protein kinase 3; transcription factor AP 1; tumor necrosis factor alpha; tumor necrosis factor alpha receptor; tumor necrosis factor alpha receptor 2; unclassified drug; leukemia inhibitory factor; LIF protein, human; MAPK1 protein, human; mitogen activated protein kinase 1; mitogen activated protein kinase 3; transcription factor AP 1; tumor necrosis factor alpha; animal cell; animal experiment; article; breast epithelium; controlled study; enzyme activation; lactation; mouse; nonhuman; priority journal; protein expression; protein induction; animal; Bagg albino mouse; cell line; cytology; enzymology; gel mobility shift assay; human; immunohistochemistry; mammary gland; metabolism; physiology; Western blotting; Animals; Blotting, Western; Cell Line; Electrophoretic Mobility Shift Assay; Enzyme Activation; Humans; Immunohistochemistry; Leukemia Inhibitory Factor; Mammary Glands, Human; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Transcription Factor AP-1; Tumor Necrosis Factor-alpha
Año:2010
Volumen:110
Número:4
Página de inicio:857
Página de fin:865
DOI: http://dx.doi.org/10.1002/jcb.22595
Título revista:Journal of Cellular Biochemistry
Título revista abreviado:J. Cell. Biochem.
ISSN:07302312
CODEN:JCEBD
CAS:mitogen activated protein kinase 1, 137632-08-7; mitogen activated protein kinase 3, 137632-07-6; Leukemia Inhibitory Factor; LIF protein, human; MAPK1 protein, human; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Transcription Factor AP-1; Tumor Necrosis Factor-alpha
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07302312_v110_n4_p857_Levy

Referencias:

  • Ahn, J.D., Morishita, R., Kaneda, Y., Lee, S.-J., Kwon, K.-Y., Choi, S.-Y., Lee, K.-U., Lee, I.-K., Inhibitory effects of novel AP-1 decoy oligodeoxynucleotides on vascular smooth muscle cell proliferation in vitro and neointimal formation in vivo (2002) Circulation Research, 90 (12), pp. 1325-1332. , DOI 10.1161/01.RES.0000023200.19316.D5
  • Baud, V., Karin, M., Signal transduction by tumor necrosis factor and its relatives (2001) Trends in Cell Biology, 11 (9), pp. 372-377. , DOI 10.1016/S0962-8924(01)02064-5, PII S0962892401020645
  • Baxter, F.O., Came, P.J., Abell, K., Kedjouar, B., Huth, M., Rajewsky, K., Pasparakis, M., Watson, C.J., IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cells (2006) Development, 133, pp. 3485-3494
  • Bhatt, H., Brunet, L.J., Stewart, C.L., Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation (1991) Proceedings of the National Academy of Sciences of the United States of America, 88 (24), pp. 11408-11412
  • Blaustein, M., Pelisch, F., Coso, O.A., Bissell, M.J., Kornblihtt, A.R., Srebrow, A., Mammary epithelial-mesenchymal interaction regulates fibronectin alternative splicing via phosphatidylinositol 3-kinase (2004) J Biol Chem, 279, pp. 21029-21037
  • Boutet, P., Sulon, J., Closset, R., Detilleux, J., Beckers, J.F., Bureau, F., Lekeux, P., Prolactin-induced activation of nuclear factor kappaB in bovine mammary epithelial cells: Role in chronic mastitis (2007) J Dairy Sci, 90, pp. 155-164
  • Cavigelli, M., Dolfi, F., Claret, F.X., Karin, M., Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation (1995) EMBO J, 14, pp. 5957-5964
  • Chapman, R.S., Lourenco, P.C., Tonner, E., Flint, D.J., Selbert, S., Takeda, K., Akira, S., Watson, C.J., Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3 (1999) Genes Dev, 13, pp. 2604-2616
  • Clarkson, R.W., Wayland, M.T., Lee, J., Freeman, T., Watson, C.J., Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression (2004) Breast Cancer Res, 6, pp. R92-109
  • Dri, P., Haas, E., Cramer, R., Menegazzi, R., Gasparini, C., Martinelli, R., Scheurich, P., Patriarca, P., Role of the 75-kDa TNF receptor in TNF-induced activation of neutrophil respiratory burst (1999) J Immunol, 162, pp. 460-466
  • Garcia-Tunon, I., Ricote, M., Ruiz, A., Fraile, B., Paniagua, R., Royuela, M., Role of tumor necrosis factor-alpha and its receptors in human benign breast lesions and tumors (in situ and infiltrative) (2006) Cancer Sci, 97, pp. 1044-1049
  • Garcia-Tunon, I., Ricote, M., Ruiz, A., Fraile, B., Paniagua, R., Royuela, M., OSM, LIF, its receptors, and its relationship with the malignance in human breast carcinoma (in situ and in infiltrative) (2008) Cancer Invest, 26, pp. 222-229
  • Jaggi, R., Marti, A., Guo, K., Feng, Z., Friis, R.R., Regulation of a Physiological Apoptosis: Mouse Mammary Involution (1996) Journal of Dairy Science, 79 (6), pp. 1074-1084
  • Kalthoff, H., Roeder, C., Brockhaus, M., Thiele, H.-G., Schmiegel, W., Tumor necrosis factor (TNF) up-regulates the expression of p75 but not p55 TNF receptors, and both receptors mediate, independently of each other, up- Regulation of transforming growth factor alpha and epidermal growth factor receptor mRNA (1993) Journal of Biological Chemistry, 268 (4), pp. 2762-2766
  • Kellokumpu-Lehtinen, P., Talpaz, M., Harris, D., Van, Q., Kurzrock, R., Estrov, Z., Leukemia-inhibitory factor stimulates breast, kidney and prostate cancer cell proliferation by paracrine and autocrine pathways (1996) Int J Cancer, 66, pp. 515-519
  • Kritikou, E.A., Sharkey, A., Abell, K., Came, P.J., Anderson, E., Clarkson, R.W., Watson, C.J., A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland (2003) Development, 130, pp. 3459-3468
  • Kyriakis, J.M., Avruch, J., Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation (2001) Physiological Reviews, 81 (2), pp. 807-869
  • Larrick, J.W., Wright, S.C., Cytotoxic mechanism of tumor necrosis factoralpha (1990) FASEB J, 4, pp. 3215-3223
  • Lewis, M., Tartaglia, L.A., Lee, A., Bennett, G.L., Rice, G.C., Wong, G.H., Chen, E.Y., Goeddel, D.V., Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific (1991) Proc Natl Acad Sci USA, 88, pp. 2830-2834
  • Li, M., Liu, X., Robinson, G., Bar-Peled, U., Wagner, K.U., Young, W.S., Hennighausen, L., Furth, P.A., Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution (1997) Proc Natl Acad Sci USA, 94, pp. 3425-3430
  • Marti, A., Lazar, H., Ritter, P., Jaggi, R., Transcription factor activities and gene expression during mouse mammary gland involution (1999) J Mammary Gland Biol Neoplasia, 4, pp. 145-152
  • Murtagh, J., McArdle, E., Gilligan, E., Thornton, L., Furlong, F., Martin, F., Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling (2004) J Cell Biol, 166, pp. 133-143
  • Neumann, B., Machleidt, T., Lifka, A., Pfeffer, K., Vestweber, D., Mak, T.W., Holzmann, B., Kronke, M., Crucial role of 55-kilodalton TNF receptor in TNF-induced adhesion molecule expression and leukocyte organ infiltration (1996) J Immunol, 156, pp. 1587-1593
  • Quaglino, A., Schere-Levy, C., Romorini, L., Meiss, R.P., Kordon, E.C., Mouse mammary tumors display Stat3 activation dependent on leukemia inhibitory factor signaling (2007) Breast Cancer Res, 9, pp. R69
  • Quaglino, A., Salierno, M., Pellegrotti, J., Rubinstein, N., Kordon, E.C., Mechanical strain induces involution-associated events in mammary epithelial cells (2009) BMC Cell Biol, 10, p. 55
  • Rivas, M.A., Carnevale, R.P., Proietti, C.J., Rosemblit, C., Beguelin, W., Salatino, M., Charreau, E.H., Schillaci, R., TNF alpha acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-kappa B-dependent pathways (2008) Exp Cell Res, 314, pp. 509-529
  • Schere-Levy, C., Buggiano, V., Quaglino, A., Gattelli, A., Cirio, M.C., Piazzon, I., Vanzulli, S., Kordon, E.C., Leukemia inhibitory factor induces apoptosis of the mammary epithelial cells and participates in mouse mammary gland involution (2003) Exp Cell Res, 282, pp. 35-47
  • Shea-Eaton, W.K., Lee, P.P., Ip, M.M., Regulation of milk protein gene expression in normal mammary epithelial cells by tumor necrosis factor (2001) Endocrinology, 142, pp. 2558-2568
  • Srivastava, A.K., Qin, X., Wedhas, N., Arnush, M., Linkhart, T.A., Chadwick, R.B., Kumar, A., Tumor necrosis factor-alpha augments matrix metalloproteinase-9 production in skeletal muscle cells through the activation of transforming growth factor-beta-activated kinase 1 (TAK1)-dependent signaling pathway (2007) J Biol Chem, 282, pp. 35113-35124
  • Strange, R., Li, F., Saurer, S., Burkhardt, A., Friis, R.R., Apoptotic cell death and tissue remodelling during mouse mammary gland involution (1992) Development, 115, pp. 49-58
  • Sugimoto, M., Fujikawa, A., Womack, J.E., Sugimoto, Y., Evidence that bovine forebrain embryonic zinc finger-like gene influences immune response associated with mastitis resistance (2006) Proc Natl Acad Sci USA, 103, pp. 6454-6459
  • Tanos, T., Marinissen, M.J., Leskow, F.C., Hochbaum, D., Martinetto, H., Gutkind, J.S., Coso, O.A., Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light (2005) J Biol Chem, 280, pp. 18842-18852
  • Tartaglia, L.A., Weber, R.F., Figari, I.S., Reynolds, C., Palladino Jr., M.A., Goeddel, D.V., The two different receptors for tumor necrosis factor mediate distinct cellular responses (1991) Proceedings of the National Academy of Sciences of the United States of America, 88 (20), pp. 9292-9296
  • Tartaglia, L.A., Rothe, M., Hu, Y.F., Goeddel, D.V., Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor (1993) Cell, 73, pp. 213-216
  • Theiss, A.L., Simmons, J.G., Jobin, C., Lund, P.K., Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2 (2005) J Biol Chem, 280, pp. 36099-36109
  • Urban, J.L., Shepard, H.M., Rothstein, J.L., Sugarman, B.J., Schreiber, H., Tumor necrosis factor: A potent effector molecule for tumor cell killing by activated macrophages (1986) Proc Natl Acad Sci USA, 83, pp. 5233-5237
  • Vandenabeele, P., Declercq, W., Vercammen, D., Van De Craen, M., Grooten, J., Loetscher, H., Brockhaus, M., Fiers, W., Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma (1992) J Exp Med, 176, pp. 1015-1024
  • Watson, C.J., Immune cell regulators in mouse mammary development and involution (2009) J Anim Sci, 87, pp. 35-42
  • Zhao, L., Melenhorst, J.J., Hennighausen, L., Loss of interleukin 6 results in delayed mammary gland involution: A possible role for mitogen-activated protein kinase and not signal transducer and activator of transcription 3 (2002) Mol Endocrinol, 16, pp. 2902-2912
  • Zhu, Y., Fossum, C., Berg, M., Magnusson, U., Morphometric analysis of proinflammatory cytokines in mammary glands of sows suggests an association between clinical mastitis and local production of IL-1beta, IL-6 and TNF-alpha (2007) Vet Res, 38, pp. 871-882

Citas:

---------- APA ----------
Levy, C.S., Slomiansky, V., Gattelli, A., Nahmod, K., Pelisch, F., Blaustein, M., Srebrow, A.,..., Kordon, E.C. (2010) . Tumor necrosis factor alpha induces LIF expression through ERK1/2 activation in mammary epithelial cells. Journal of Cellular Biochemistry, 110(4), 857-865.
http://dx.doi.org/10.1002/jcb.22595
---------- CHICAGO ----------
Levy, C.S., Slomiansky, V., Gattelli, A., Nahmod, K., Pelisch, F., Blaustein, M., et al. "Tumor necrosis factor alpha induces LIF expression through ERK1/2 activation in mammary epithelial cells" . Journal of Cellular Biochemistry 110, no. 4 (2010) : 857-865.
http://dx.doi.org/10.1002/jcb.22595
---------- MLA ----------
Levy, C.S., Slomiansky, V., Gattelli, A., Nahmod, K., Pelisch, F., Blaustein, M., et al. "Tumor necrosis factor alpha induces LIF expression through ERK1/2 activation in mammary epithelial cells" . Journal of Cellular Biochemistry, vol. 110, no. 4, 2010, pp. 857-865.
http://dx.doi.org/10.1002/jcb.22595
---------- VANCOUVER ----------
Levy, C.S., Slomiansky, V., Gattelli, A., Nahmod, K., Pelisch, F., Blaustein, M., et al. Tumor necrosis factor alpha induces LIF expression through ERK1/2 activation in mammary epithelial cells. J. Cell. Biochem. 2010;110(4):857-865.
http://dx.doi.org/10.1002/jcb.22595