Artículo

Romanini, M.C.; Paz, D.A.; Rodríguez, N.; Rolando, A.N.; Mugnaini, M.T.; Soñez, C.A.; Bozzo, A.; Marioli, J.M.; Pastorino, I.C.; Gauna, H.F. "Relative concentrations of placental lactogen II and PRL-like protein-A in stressed rats placenta" (2007) International Journal of Morphology. 25(1):85-94
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Abstract:

The chronic stress induces functional adaptations in the hypothalamo-pituitary- adrenocortical (HPA) and in the sympathetic-medullary- adrenal axis (SAM). Both axis are considered vital regulators of the homeostasis in vertebrates (Seyle, 1936; Ostrandrer et al., 2006. On the other hand, the placenta provides highly specialized functions during gestation that are critical for the normal development of the embryo/fetus (Soares et al., 1991). We hypothesized that the chronic immobilization (IMO) stress in pregnancy rats produces alterations in prolactin concentrations in placental tissue and also changes in the response of SAM axis. Chronic stress by IMO was applied on days 12, 17 and 21 of pregnancy rats. Relative concentrations and localization of placental lactogen-II (PL-II) and the PRL- like protein A (PLP-A) in chorioalantoic placenta were estimated by Immunoblotting and Immunocytochemical analysis. The levels of catecholamines metabolite, acid 3-metoxi 4-hidroximandélico (VMA), were analyzed in stressed rats urines on 6,12,17,21 days of pregnancy, by HPLC, in order to determine the response of SAM axis. During the days of the pregnancy studied, chronic stress did not induce any changes neither in the localization nor in placental concentrations of PL-II and PLP-A. The VMA values in stressed mothers urines increased on the day 6 respecting the control ones at the same time of pregnancy. VMA values in stressed rats at 21 days of pregnancy are smaller than the respective controls. We conclude that the chronic stressed mothers activated the SAM axis at the beginning of pregnancy and then they diminished the metabolites catecholamines that were interpreted as a stress adaptation coincident with normal concentrations of both placentary prolactines at this stage of the pregnancy.

Registro:

Documento: Artículo
Título:Relative concentrations of placental lactogen II and PRL-like protein-A in stressed rats placenta
Autor:Romanini, M.C.; Paz, D.A.; Rodríguez, N.; Rolando, A.N.; Mugnaini, M.T.; Soñez, C.A.; Bozzo, A.; Marioli, J.M.; Pastorino, I.C.; Gauna, H.F.
Filiación:Departamento de Anatomía, Facultad de Agronomía Y Veterinaria, Universidad Nacional de Río Cuarto, Argentina
Facultad de Ciencias Exactas, Universidad Nacional de Río Cuarto, Argentina
Facultad de Ciencias Exactas, Universidad Nacional de Buenos Aires, Argentina
Departamento de Anatomía Animal, Facultad de Agronomía Y Veterinaria, Universidad Nacional de Río Cuarto, Ruta 8 Km 601, 5800-Río Cuarto, Argentina
Palabras clave:Chronic stress; Placental lactogen; Prolactin; Rat; SAM
Año:2007
Volumen:25
Número:1
Página de inicio:85
Página de fin:94
DOI: http://dx.doi.org/10.4067/S0717-95022007000100011
Título revista:International Journal of Morphology
Título revista abreviado:Int. J. Morphol.
ISSN:07179367
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07179367_v25_n1_p85_Romanini

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Citas:

---------- APA ----------
Romanini, M.C., Paz, D.A., Rodríguez, N., Rolando, A.N., Mugnaini, M.T., Soñez, C.A., Bozzo, A.,..., Gauna, H.F. (2007) . Relative concentrations of placental lactogen II and PRL-like protein-A in stressed rats placenta. International Journal of Morphology, 25(1), 85-94.
http://dx.doi.org/10.4067/S0717-95022007000100011
---------- CHICAGO ----------
Romanini, M.C., Paz, D.A., Rodríguez, N., Rolando, A.N., Mugnaini, M.T., Soñez, C.A., et al. "Relative concentrations of placental lactogen II and PRL-like protein-A in stressed rats placenta" . International Journal of Morphology 25, no. 1 (2007) : 85-94.
http://dx.doi.org/10.4067/S0717-95022007000100011
---------- MLA ----------
Romanini, M.C., Paz, D.A., Rodríguez, N., Rolando, A.N., Mugnaini, M.T., Soñez, C.A., et al. "Relative concentrations of placental lactogen II and PRL-like protein-A in stressed rats placenta" . International Journal of Morphology, vol. 25, no. 1, 2007, pp. 85-94.
http://dx.doi.org/10.4067/S0717-95022007000100011
---------- VANCOUVER ----------
Romanini, M.C., Paz, D.A., Rodríguez, N., Rolando, A.N., Mugnaini, M.T., Soñez, C.A., et al. Relative concentrations of placental lactogen II and PRL-like protein-A in stressed rats placenta. Int. J. Morphol. 2007;25(1):85-94.
http://dx.doi.org/10.4067/S0717-95022007000100011