Artículo
Kaplan, D.; Vazquez, M.; Lafon, S.; Schijman, A.G.; Levitus, G.; Levin, M.J. "The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: The Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system" (1993) Biological Research. 26(1-2):273-277
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Abstract:
Molecular expression cloning techniques revealed that patients with the severest clinical form of Chagas disease, chronic Chagas heart disease, presented a strong humoral response against the cloned C-terminal portion of a Trypanosoma cruzi ribosomal P protein. Parasite P antigens identification led to characterize the ribosomal P protein system in T. cruzi. Their exposed location on the ribosome, and the 'amplification' of their parasite specific, serine free C-terminal domain, generate a strong parasite specific anti-P response, that in certain cases may induce anti-P autoimmunity.
Registro:
| Documento: | Artículo |
| Título: | The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: The Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system |
| Autor: | Kaplan, D.; Vazquez, M.; Lafon, S.; Schijman, A.G.; Levitus, G.; Levin, M.J. |
| Filiación: | Instituto de Investigaciones en, Ingenieria Genetica/Biol. Molecular, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina |
| Palabras clave: | parasite antigen; ribosome protein; autoimmunity; chagas disease; conference paper; host parasite interaction; molecular cloning; nonhuman; trypanosoma cruzi; Amino Acid Sequence; Animal; Antigens, Protozoan; Autoimmunity; Chagas Disease; Chronic Disease; Comparative Study; Epitopes; Human; Molecular Sequence Data; Protozoan Proteins; Ribosomal Proteins; Support, Non-U.S. Gov't; Trypanosoma cruzi |
| Año: | 1993 |
| Volumen: | 26 |
| Número: | 1-2 |
| Página de inicio: | 273 |
| Página de fin: | 277 |
| Título revista: | Biological Research |
| Título revista abreviado: | BIOL. RES. |
| ISSN: | 07169760 |
| CODEN: | BESEE |
| CAS: | Antigens, Protozoan; Epitopes; P-JL5 protein; Protozoan Proteins; Ribosomal Proteins |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07169760_v26_n1-2_p273_Kaplan |
Citas:
---------- APA ----------
Kaplan, D., Vazquez, M., Lafon, S., Schijman, A.G., Levitus, G. & Levin, M.J. (1993) . The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: The Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system. Biological Research, 26(1-2), 273-277.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07169760_v26_n1-2_p273_Kaplan [ ]
---------- CHICAGO ----------
Kaplan, D., Vazquez, M., Lafon, S., Schijman, A.G., Levitus, G., Levin, M.J. "The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: The Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system" . Biological Research 26, no. 1-2 (1993) : 273-277.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07169760_v26_n1-2_p273_Kaplan [ ]
---------- MLA ----------
Kaplan, D., Vazquez, M., Lafon, S., Schijman, A.G., Levitus, G., Levin, M.J. "The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: The Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system" . Biological Research, vol. 26, no. 1-2, 1993, pp. 273-277.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07169760_v26_n1-2_p273_Kaplan [ ]
---------- VANCOUVER ----------
Kaplan, D., Vazquez, M., Lafon, S., Schijman, A.G., Levitus, G., Levin, M.J. The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: The Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system. BIOL. RES. 1993;26(1-2):273-277.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07169760_v26_n1-2_p273_Kaplan [ ]
