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Abstract:

Apoptosis is a genetically controlled form of cell suicide. Due to the cyclic nature of the female reproductive system, the ovary, the endometrium and the mammary gland sustain continuous cycles of cell growth and apoptosis in response to hormonal changes. Apoptotic cell death plays multiple roles during embryonic and organ development. It is involved in sculpturing tissues and serves to delete structures that are no longer required. It is clear that apoptosis plays an active and important role in ovarian physiological functions. Apoptosis plays a major role during folliculogenesis and dominant follicle selection and also plays part in corpus luteum regression. In addition, it has been shown that programmed cell death plays important roles in the mammary gland development and ductal morphogenesis. During puberty, lumen formation is associated with the selective apoptosis of centrally located cells. In turn, postlactational involution of the mammary gland is characterized by the secretory epithelial cells undergoing programmed cell death. Apoptosis has also been associated with physiological, as well as pathological, endometrial processes such as cancer and endometriosis. The delicate balance between apoptosis and cell proliferation is essential in controlling the cyclical growth of the reproductive tissues and plays an important role in the prevention of neoplastic transformation.

Registro:

Documento: Artículo
Título:Relevance of apoptosis in the female reproductive system
Autor:Meresman, G.
Filiación:Instituto de Biología Experimental, IBYME-CONICET, Ciudad Autónoma de Buenos Aires (1428), Argentina
Palabras clave:Apoptosis; Endometriosis; Endometrium; Mammary gland; Ovary; apoptosis regulatory protein; sex hormone; animal; apoptosis; breast; Caenorhabditis elegans; corpus luteum; cytology; embryo development; endometriosis; epithelium cell; female; female genital system; female genital tract tumor; human; lactation; menstrual cycle; metabolism; morphogenesis; ovary follicle; ovulation; pathology; physiology; pregnancy; prenatal development; puberty; review; ultrastructure; article; cell growth; endometrium; endometrium cancer; mammary gland; organogenesis; ovary; ovary follicle development; Animals; Apoptosis; Apoptosis Regulatory Proteins; Breast; Caenorhabditis elegans; Corpus Luteum; Embryonic Development; Endometriosis; Epithelial Cells; Female; Genital Neoplasms, Female; Genitalia, Female; Gonadal Steroid Hormones; Humans; Lactation; Menstrual Cycle; Morphogenesis; Ovarian Follicle; Ovulation; Pregnancy; Puberty
Año:2011
Volumen:52
Número:3
Página de inicio:274
Página de fin:290
Título revista:Investigacion Clinica
Título revista abreviado:Invest. Clin.
ISSN:05355133
CODEN:ICLIA
CAS:Apoptosis Regulatory Proteins; Gonadal Steroid Hormones
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05355133_v52_n3_p274_Meresman

Referencias:

  • van Cruchten, S., van Den, B.W., Morphological and biochemical aspects of apoptosis, oncosis and necrosis (2002) Anat Histol Embryol, 31, pp. 214-223
  • Assuncao, G.C., Linden, R., Programmed cell deaths. Apoptosis and alternative death-styles (2004) Eur J Biochem, 271, pp. 1638-1650
  • Lawen, A., Apoptosis-an introduction (2003) Bioessays, 25, pp. 888-896
  • Allen, R.T., Hunter, W.J., Agrawal, D.K., Morphological and biochemical characterization and analysis of apoptosis (1997) J Pharmacol Toxicol Methods, 37, pp. 215-228
  • Barnhart, B.C., Alappat, E.C., Peter, M.E., The CD95 type I/type II model (2003) Semin Immunol, 15, pp. 185-193
  • Cohen, G.M., Caspases: The executioners of apoptosis (1997) Biochem J, 326 (PART 1), pp. 1-16
  • Peter, M.E., Krammer, P.H., The CD95 (APO-1/Fas) DISC and beyond (2003) Cell Death Differ, 10, pp. 26-35
  • Youle, R.J., Strasser, A., The BCL-2 protein family: Opposing activities that mediate cell death (2008) Nat Rev Mol Cell Biol, 9, pp. 47-59
  • Burlacu, A., Regulation of apoptosis by Bcl-2 family proteins (2003) J Cell Mol Med, 7, pp. 249-257
  • Gross, A., McDonnell, J.M., Korsmeyer, S.J., BCL-2 family members and the mitochondria in apoptosis (1999) Genes Dev, 13, pp. 1899-1911
  • Steller, H., Mechanisms and genes of cellular suicide (1995) Science, 267, pp. 1445-1449
  • Abud, H.E., Shaping developing tissues by apoptosis (2004) Cell Death Differ, 11, pp. 797-799
  • Capel, B., The battle of the sexes (2000) Mech Dev, 92, pp. 89-103
  • Kaipia, A., Hsueh, A.J., Regulation of ovarian follicle atresia (1997) Annu Rev Physiol, 59, pp. 349-363
  • Hussein, M.R., Apoptosis in the ovary: Molecular mechanisms (2005) Hum Reprod Update, 11, pp. 162-177
  • McGee, E.A., Hsueh, A.J., Initial and cyclic recruitment of ovarian follicles (2000) Endocr Rev, 21, pp. 200-214
  • Markstrom, E., Svensson, E.C., Shao, R., Svanberg, B., Billig, H., Survival factors regulating ovarian apoptosis - dependence on follicle differentiation (2002) Reproduction, 123, pp. 23-30
  • Sugino, N., Suzuki, T., Kashida, S., Karube, A., Takiguchi, S., Kato, H., Expression of Bcl-2 and Bax in the human corpus luteum during the menstrual cycle and in early pregnancy: Regulation by human chorionic gonadotropin (2000) J Clin Endocrinol Metab, 85, pp. 4379-4386
  • Krysko, D.V., Diez-Fraile, A., Criel, G., Svistunov, A.A., Vandenabeele, P., D'herde, K., Life and death of female gametes during oogenesis and folliculogenesis (2008) Apoptosis, 13, pp. 1065-1087
  • Green, K.A., Streuli, C.H., Apoptosis regulation in the mammary gland (2004) Cell Mol Life Sci, 61, pp. 1867-1883
  • Humphreys, R.C., Krajewska, M., Krnacik, S., Jaeger, R., Weiher, H., Krajewski, S., Reed, J.C., Rosen, J.M., Apoptosis in the terminal endbud of the murine mammary gland: A mechanism of ductal morphogenesis (1996) Development, 122, pp. 4013-4022
  • Andres, A.C., Strange, R., Apoptosis in the estrous and menstrual cycles (1999) J Mammary Gland Biol Neoplasia, 4, pp. 221-228
  • Jager, R., Targeting the death machinery in mammary epithelial cells: Implications for breast cancer from transgenic and tissue culture experiments (2007) Crit Rev Oncol Hematol, 63, pp. 231-240
  • Feuerhake, F., Sigg, W., Hofter, E.A., Unterberger, P., Welsch, U., Cell proliferation, apoptosis, and expression of Bcl-2 and Bax in non-lactating human breast epithelium in relation to the menstrual cycle and reproductive history (2003) Breast Cancer Res Treat, 77, pp. 37-48
  • Mills, K.R., Reginato, M., Debnath, J., Queenan, B., Brugge, J.S., Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro (2004) Proc Natl Acad Sci U S A, 101, pp. 3438-3443
  • Mor, G., Straszewski, S., Kamsteeg, M., Role of the Fas/Fas ligand system in female reproductive organs: Survival and apoptosis (2002) Biochem Pharmacol, 64, pp. 1305-1315
  • Marti, A., Graber, H., Lazar, H., Ritter, P.M., Baltzer, A., Srinivasan, A., Jaggi, R., Caspases: Decoders of apoptotic signals during mammary involution. Caspase activation during involution (2000) Adv Exp Med Biol, 480, pp. 195-201
  • Metcalfe, A.D., Gilmore, A., Klinowska, T., Oliver, J., Valentijn, A.J., Brown, R., Ross, A., Streuli, C.H., Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland (1999) J Cell Sci, 112 (PART 11), pp. 1771-1783
  • Kayisli, U.A., Guzeloglu-Kayisli, O., Arici, A., Endocrine-immune interactions in human endometrium (2004) Ann N Y Acad Sci, 1034, pp. 50-63
  • Harada, T., Kaponis, A., Iwabe, T., Taniguchi, F., Makrydimas, G., Sofikitis, N., Paschopoulos, M., Terakawa, N., Apoptosis in human endometrium and endometriosis (2004) Hum Reprod Update, 10, pp. 29-38
  • Hopwood, D., Levison, D.A., Atrophy and apoptosis in the cyclical human endometrium (1976) J Pathol, 119, pp. 159-166
  • Harada, T., Taniguchi, F., Izawa, M., Ohama, Y., Takenaka, Y., Tagashira, Y., Ikeda, A., Terakawa, N., Apoptosis and endometriosis (2007) Front Biosci, 12, pp. 3140-3151
  • Tao, X.J., Tilly, K.I., Maravei, D.V., Shifren, J.L., Krajewski, S., Reed, J.C., Tilly, J.L., Isaacson, K.B., Differential expression of members of the bcl-2 gene family in proliferative and secretory human endometrium: Glandular epithelial cell apoptosis is associated with increased expression of bax (1997) J Clin Endocrinol Metab, 82, pp. 2738-2746
  • Jones, R.K., Searle, R.F., Bulmer, J.N., Apoptosis and bcl-2 expression in normal human endometrium, endometriosis and adenomyosis (1998) Hum Reprod, 13, pp. 3496-3502
  • Wei, P., Jin, X., Tao, S.X., Han, C.S., Liu, Y.X., Fas, FasL, Bcl-2, and Bax in the endometrium of rhesus monkey during the menstrual cycle (2005) Mol Reprod Dev, 70, pp. 478-484
  • Yamashita, H., Otsuki, Y., Matsumoto, K., Ueki, K., Ueki, M., Fas ligand, Fas antigen and Bcl-2 expression in human endometrium during the menstrual cycle (1999) Mol Hum Reprod, 5, pp. 358-364
  • Otsuki, Y., Apoptosis in human endometrium: Apoptotic detection methods and signaling (2001) Med Electron Microsc, 34, pp. 166-173
  • Selam, B., Kayisli, U.A., Mulayim, N., Arici, A., Regulation of Fas ligand expression by estradiol and progesterone in human endometrium (2001) Biol Reprod, 65, pp. 979-985
  • McLeod, B.S., Retzloff, M.G., Epidemiology of endometriosis: An assessment of risk factors (2010) Clin Obstet Gynecol, 53, pp. 389-396
  • Wu, M.H., Shoji, Y., Chuang, P.C., Tsai, S.J., Endometriosis: Disease pathophysiology and the role of prostaglandins (2007) Expert Rev Mol Med, 9, pp. 1-20
  • Sampson, J.A., Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity (1927) Am J Obstet Gynecol, 14, pp. 422-469
  • Jensen, J.R., Coddington, C.C., Evolving spectrum: The pathogenesis of endometriosis (2010) Clin Obstet Gynecol, 53, pp. 379-388
  • Ulukus, M., Cakmak, H., Arici, A., The role of endometrium in endometriosis (2006) J Soc Gynecol Investig, 13, pp. 467-476
  • Meresman, G.F., Vighi, S., Buquet, R.A., Contreras-Ortiz, O., Tesone, M., Rumi, L.S., Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis (2000) Fertil Steril, 74, pp. 760-766
  • Dmowski, W.P., Gebel, H., Braun, D.P., Decreased apoptosis and sensitivity to macrophage mediated cytolysis of endometrial cells in endometriosis (1998) Hum Reprod Update, 4, pp. 696-701
  • Meresman, G.F., Auge, L., Baranao, R.I., Lombardi, E., Tesone, M., Sueldo, C., Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis (2002) Fertil Steril, 77, pp. 1141-1147
  • McLaren, J., Prentice, A., Charnock-Jones, D.S., Sharkey, A.M., Smith, S.K., Immunolocalization of the apoptosis regulating proteins Bcl-2 and Bax in human endometrium and isolated peritoneal fluid macrophages in endometriosis (1997) Hum Reprod, 12, pp. 146-152
  • Dufournet, C., Uzan, C., Fauvet, R., Cortez, A., Siffroi, J.P., Darai, E., Expression of apoptosis-related proteins in peritoneal, ovarian and colorectal endometriosis (2006) J Reprod Immunol, 70, pp. 151-162
  • Deligdisch, L., Hormonal pathology of the endometrium (2000) Mod Pathol, 13, pp. 285-294
  • Pierro, E., Minici, F., Alesiani, O., Miceli, F., Proto, C., Screpanti, I., Mancuso, S., Lanzone, A., Stromal-epithelial interactions modulate estrogen responsiveness in normal human endometrium (2001) Biol Reprod, 64, pp. 831-838
  • Rider, V., Kimler, B.F., Justice, W.M., Progesterone- growth factor interactions in uterine stromal cells (1998) Biol Reprod, 59, pp. 464-469
  • Moyer, D.L., Felix, J.C., The effects of progesterone and progestins on endometrial proliferation (1998) Contraception, 57, pp. 399-403
  • Critchley, H.O., Tong, S., Cameron, S.T., Drudy, T.A., Kelly, R.W., Baird, D.T., Regulation of bcl-2 gene family members in human endometrium by antiprogestin administration in vivo (1999) J Reprod Fertil, 115, pp. 389-395
  • Grundker, C., Schlotawa, L., Viereck, V., Eicke, N., Horst, A., Kairies, B., Emons, G., Antiproliferative effects of the GnRH antagonist cetrorelix and of GnRH-II on human endometrial and ovarian cancer cells are not mediated through the GnRH type I receptor (2004) Eur J Endocrinol, 151, pp. 141-149
  • Borroni, R., di Blasio, A.M., Gaffuri, B., Santorsola, R., Busacca, M., Vigano, P., Vignali, M., Expression of GnRH receptor gene in human ectopic endometrial cells and inhibition of their proliferation by leuprolide acetate (2000) Mol Cell Endocrinol, 159, pp. 37-43
  • Vignali, M., Molecular action of GnRH analogues on ectopic endometrial cells (1998) Gynecol Obstet Invest, 45 (SUPPL. 1), pp. 2-5
  • Andreu, C., Parborell, F., Vanzulli, S., Chemes, H., Tesone, M., Regulation of follicular luteinization by a gonadotropinreleasing hormone agonist: Relationship between steroidogenesis and apoptosis (1998) Mol Reprod Dev, 51, pp. 287-294
  • Wang, Y., Matsuo, H., Kurachi, O., Maruo, T., Down-regulation of proliferation and up-regulation of apoptosis by gonadotropin- releasing hormone agonist in cultured uterine leiomyoma cells (2002) Eur J Endocrinol, 146, pp. 447-456
  • Tesone, M., Bilotas, M., Baranao, R.I., Meresman, G., The role of GnRH analogues in endometriosis-associated apoptosis and angiogenesis (2008) Gynecol Obstet Invest, 66 (SUPPL. 1), pp. 10-18
  • Bilotas, M., Baranao, R.I., Buquet, R., Sueldo, C., Tesone, M., Meresman, G., Effect of GnRH analogues on apoptosis and expression of Bcl-2, Bax, Fas and FasL proteins in endometrial epithelial cell cultures from patients with endometriosis and controls (2007) Hum Reprod, 22, pp. 644-653
  • Ferrero, S., Abbamonte, L.H., Anserini, P., Remorgida, V., Ragni, N., Future perspectives in the medical treatment of endometriosis (2005) Obstet Gynecol Surv, 60, pp. 817-826
  • Bilotas, M., Meresman, G., Stella, I., Sueldo, C., Baranao, R.I., Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis (2010) Fertil Steril, 93, pp. 2513-2518
  • Olivares, C., Bilotas, M., Buquet, R., Borghi, M., Sueldo, C., Tesone, M., Meresman, G., Effects of a selective cyclooxygenase-2 inhibitor on endometrial epithelial cells from patients with endometriosis (2008) Hum Reprod, 23, pp. 2701-2708
  • Goss, P.E., Breast cancer prevention-clinical trials strategies involving aromatase inhibitors (2003) J Steroid Biochem Mol Biol, 86, pp. 487-493
  • Thiantanawat, A., Long, B.J., Brodie, A.M., Signaling pathways of apoptosis activated by aromatase inhibitors and antiestrogens (2003) Cancer Res, 63, pp. 8037-8050
  • Meresman, G.F., Bilotas, M., Abello, V., Buquet, R., Tesone, M., Sueldo, C., Effects of aromatase inhibitors on proliferation and apoptosis in eutopic endometrial cell cul- tures from patients with endometriosis (2005) Fertil Steril, 84, pp. 459-463
  • Basu, G.D., Pathangey, L.B., Tinder, T.L., Gendler, S.J., Mukherjee, P., Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells (2005) Breast Cancer Res, 7, pp. R422-R435
  • Jendrossek, V., Handrick, R., Belka, C., Celecoxib activates a novel mitochondrial apoptosis signaling pathway (2003) FASEB J, 17, pp. 1547-1549
  • Matsuzaki, S., Canis, M., Darcha, C., Dallel, R., Okamura, K., Mage, G., Cyclooxygenase-2 selective inhibitor prevents implantation of eutopic endometrium to ectopic sites in rats (2004) Fertil Steril, 82, pp. 1609-1615
  • Lai, G.H., Zhang, Z., Sirica, A.E., Celecoxib acts in a cyclooxygenase-2-independent manner and in synergy with emodin to suppress rat cholangiocarcinoma growth in vitro through a mechanism involving enhanced Akt inactivation and increased activation of caspases-9 and -3 (2003) Mol Cancer Ther, 2, pp. 265-271
  • Olivares, C., Ricci, A., Bilotas, M., Baranao, R.I., Meresman, G., The inhibitory effect of celecoxib and rosiglitazone on experimental endometriosis (2011) Fertil Steril, 96, pp. 428-433
  • Kim, R., Recent advances in understanding the cell death pathways activated by anticancer therapy (2005) Cancer, 103, pp. 1551-1560

Citas:

---------- APA ----------
(2011) . Relevance of apoptosis in the female reproductive system . Investigacion Clinica, 52(3), 274-290.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05355133_v52_n3_p274_Meresman [ ]
---------- CHICAGO ----------
Meresman, G. "Relevance of apoptosis in the female reproductive system " . Investigacion Clinica 52, no. 3 (2011) : 274-290.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05355133_v52_n3_p274_Meresman [ ]
---------- MLA ----------
Meresman, G. "Relevance of apoptosis in the female reproductive system " . Investigacion Clinica, vol. 52, no. 3, 2011, pp. 274-290.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05355133_v52_n3_p274_Meresman [ ]
---------- VANCOUVER ----------
Meresman, G. Relevance of apoptosis in the female reproductive system . Invest. Clin. 2011;52(3):274-290.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05355133_v52_n3_p274_Meresman [ ]