Abstract:
The 70 kDa heat-shock protein (Hsp70) exhibits a broad range of chaperone functions that respond both to internal and external stresses, and its heat-induced expression both declines with age and reduces age-specific mortality rates. Here we test for changes in both longevity and the level of Hsp70-induced expression as correlated responses to selection on both heat-stress resistance and longevity in D. melanogaster. Three replicated H lines were heat-stress selected and compared to their respective non-selected controls (C lines) in the 25th generation of heat-stress selection. The direct response in heat-stress resistance was 56% in males and 38% in females. Heat-stress selection improved longevity in males at normal temperatures. All lines were subsequently subjected to one generation of truncation selection on longevity (selection intensity, i=1.28 for H lines and 1.36 for C lines). The heat-induced Hsp70 expression seems to increase very weakly by heat-stress selection but shows a dramatic and persistent decline by selecting for long-lived flies. A mechanism of longevity selection, involving changes in Hsp70 regulation, is suggested. © 2003 Elsevier Science Inc. All rights reserved.
Registro:
Documento: |
Artículo
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Título: | Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals |
Autor: | Norry, F.M.; Loeschcke, V. |
Filiación: | Department of Ecology and Genetics, University of Aarhus, Bldg. 540, Ny Munkegade, DK-8000 Aarhus C, Denmark Depto. de Ecologia, Genet./Evol., Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, (1428) Buenos Aires, Argentina
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Palabras clave: | Drosophila; Heat-stress resistance; Hsp70; Longevity; Truncation selection; chaperone; heat shock protein 70; aging; article; controlled study; Drosophila melanogaster; female; heat stress; heritability; lifespan; longevity; male; nonhuman; priority journal; protein expression; protein function; regulatory mechanism; temperature sensitivity; Melanogaster |
Año: | 2003
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Volumen: | 38
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Número: | 6
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Página de inicio: | 673
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Página de fin: | 681
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DOI: |
http://dx.doi.org/10.1016/S0531-5565(03)00057-3 |
Título revista: | Experimental Gerontology
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Título revista abreviado: | Exp. Gerontol.
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ISSN: | 05315565
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CODEN: | EXGEA
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05315565_v38_n6_p673_Norry |
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Citas:
---------- APA ----------
Norry, F.M. & Loeschcke, V.
(2003)
. Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals. Experimental Gerontology, 38(6), 673-681.
http://dx.doi.org/10.1016/S0531-5565(03)00057-3---------- CHICAGO ----------
Norry, F.M., Loeschcke, V.
"Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals"
. Experimental Gerontology 38, no. 6
(2003) : 673-681.
http://dx.doi.org/10.1016/S0531-5565(03)00057-3---------- MLA ----------
Norry, F.M., Loeschcke, V.
"Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals"
. Experimental Gerontology, vol. 38, no. 6, 2003, pp. 673-681.
http://dx.doi.org/10.1016/S0531-5565(03)00057-3---------- VANCOUVER ----------
Norry, F.M., Loeschcke, V. Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals. Exp. Gerontol. 2003;38(6):673-681.
http://dx.doi.org/10.1016/S0531-5565(03)00057-3