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Abstract:

The 70 kDa heat-shock protein (Hsp70) exhibits a broad range of chaperone functions that respond both to internal and external stresses, and its heat-induced expression both declines with age and reduces age-specific mortality rates. Here we test for changes in both longevity and the level of Hsp70-induced expression as correlated responses to selection on both heat-stress resistance and longevity in D. melanogaster. Three replicated H lines were heat-stress selected and compared to their respective non-selected controls (C lines) in the 25th generation of heat-stress selection. The direct response in heat-stress resistance was 56% in males and 38% in females. Heat-stress selection improved longevity in males at normal temperatures. All lines were subsequently subjected to one generation of truncation selection on longevity (selection intensity, i=1.28 for H lines and 1.36 for C lines). The heat-induced Hsp70 expression seems to increase very weakly by heat-stress selection but shows a dramatic and persistent decline by selecting for long-lived flies. A mechanism of longevity selection, involving changes in Hsp70 regulation, is suggested. © 2003 Elsevier Science Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals
Autor:Norry, F.M.; Loeschcke, V.
Filiación:Department of Ecology and Genetics, University of Aarhus, Bldg. 540, Ny Munkegade, DK-8000 Aarhus C, Denmark
Depto. de Ecologia, Genet./Evol., Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, (1428) Buenos Aires, Argentina
Palabras clave:Drosophila; Heat-stress resistance; Hsp70; Longevity; Truncation selection; chaperone; heat shock protein 70; aging; article; controlled study; Drosophila melanogaster; female; heat stress; heritability; lifespan; longevity; male; nonhuman; priority journal; protein expression; protein function; regulatory mechanism; temperature sensitivity; Melanogaster
Año:2003
Volumen:38
Número:6
Página de inicio:673
Página de fin:681
DOI: http://dx.doi.org/10.1016/S0531-5565(03)00057-3
Título revista:Experimental Gerontology
Título revista abreviado:Exp. Gerontol.
ISSN:05315565
CODEN:EXGEA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05315565_v38_n6_p673_Norry

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Citas:

---------- APA ----------
Norry, F.M. & Loeschcke, V. (2003) . Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals. Experimental Gerontology, 38(6), 673-681.
http://dx.doi.org/10.1016/S0531-5565(03)00057-3
---------- CHICAGO ----------
Norry, F.M., Loeschcke, V. "Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals" . Experimental Gerontology 38, no. 6 (2003) : 673-681.
http://dx.doi.org/10.1016/S0531-5565(03)00057-3
---------- MLA ----------
Norry, F.M., Loeschcke, V. "Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals" . Experimental Gerontology, vol. 38, no. 6, 2003, pp. 673-681.
http://dx.doi.org/10.1016/S0531-5565(03)00057-3
---------- VANCOUVER ----------
Norry, F.M., Loeschcke, V. Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals. Exp. Gerontol. 2003;38(6):673-681.
http://dx.doi.org/10.1016/S0531-5565(03)00057-3