Artículo

de Pisarev, D.L.K.; de Sancovich, A.M.F.; Sancovich, H.A. "Hepatic indices of thyroid status in rats treated with hexachlorobenzene" (1995) Journal of Endocrinological Investigation. 18(4):271-276
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

The functional thyroid status of hexachlorobenzene (HCB)-treated rats was studied. HCB caused a depletion of serum thyroxine (T4 ), but did not change L-3,5,3’-triiodothyronine (T3) levels in serum of rats. The activities of the thyroid regulated mitochondrial enzyme L-glycerolphosphate dehydrogenase (LGPD) and cytosolic enzymes, malic enzyme (ME), glucose-6-phosphate dehydrogenase (G6PD) and 6-phos-phogluconate dehydrogenase (6PGD) were assayed in livers of normal and HCB (100 mg/100 g bw) treated Wistar rats. Mitochondrial LGPD activity did not change significantly, however ME, 6GPD and G6PD were induced by HCB only in non-thyroidectomized animals. The absence of cytosolic enzymes induction in thyroidectomized rats treated with HCB indicates that HCB is not intrinsically thyromimetic. The induction of hepatic ME, G6PD and 6PGD activities in HCB thyroidectomized rats was dependent on the presence of thyroid hormone. The unchanged activity of mitochondrial LGPD in contrast to the increased activities of the cytosolic enzymes ME, G6PD and 6PGD is not consistent with a shift in functional thyroid status following HCB treatment. © 1995, Italian Society of Endocrinology (SIE). All rights reserved.

Registro:

Documento: Artículo
Título:Hepatic indices of thyroid status in rats treated with hexachlorobenzene
Autor:de Pisarev, D.L.K.; de Sancovich, A.M.F.; Sancovich, H.A.
Filiación:Departamentos de Quimica Biológica, Facultad de Medicina, Argentina
Departamentos de Quimica Biológica, Facultad de Ciencias Exactas Y Naturales, Buenos Aires, Argentina
Vidal 2483, 8°B, Buenos Aires, 1428, Argentina
Palabras clave:6-phosphogluconate dehydrogenase; glucose-6-phosphate dehydrogenase; Hexachlorobenzene; L-glycerolphosphate dehydrogenase; malic enzyme; triiodothyronine; glucose 6 phosphate dehydrogenase; glycerol 3 phosphate dehydrogenase; hexachlorobenzene; liothyronine; liver enzyme; malate dehydrogenase (decarboxylating); mitochondrial enzyme; phosphogluconate dehydrogenase; thyrotropin; thyroxine; animal experiment; animal model; article; controlled study; enzyme activity; enzyme induction; female; liothyronine blood level; liver function; nonhuman; rat; thyroid function; thyrotropin blood level; thyroxine blood level; Animal; Body Weight; Female; Glucosephosphate Dehydrogenase; Glycerolphosphate Dehydrogenase; Hexachlorobenzene; Liver; Malate Dehydrogenase; Organ Weight; Phosphogluconate Dehydrogenase; Rats; Rats, Wistar; Support, Non-U.S. Gov't; Thyroid Gland; Thyroid Hormones
Año:1995
Volumen:18
Número:4
Página de inicio:271
Página de fin:276
DOI: http://dx.doi.org/10.1007/BF03347812
Título revista:Journal of Endocrinological Investigation
Título revista abreviado:J. Endocrinol. Invest.
ISSN:03914097
CAS:glucose 6 phosphate dehydrogenase, 37259-83-9, 9001-40-5; glycerol 3 phosphate dehydrogenase, 9001-49-4; hexachlorobenzene, 118-74-1, 55600-34-5; liothyronine, 6138-47-2, 6893-02-3; malate dehydrogenase (decarboxylating), 9028-46-0, 9074-02-6, 9080-52-8; phosphogluconate dehydrogenase, 9001-82-5; thyrotropin, 9002-71-5; thyroxine, 7488-70-2; Glucosephosphate Dehydrogenase, EC 1.1.1.49; Glycerolphosphate Dehydrogenase, EC 1.1.-; Hexachlorobenzene, 118-74-1; malate dehydrogenase (decarboxylating), EC 1.1.1.39; Malate Dehydrogenase, EC 1.1.1.37; Phosphogluconate Dehydrogenase, EC 1.1.1.43; Thyroid Hormones
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03914097_v18_n4_p271_dePisarev

Referencias:

  • Courtney, K.D., Hexaclorobenzene (HCB): a review (1979) Environm. Res., 20, p. 225
  • Strik J.J.T.W.A. The occurrence of chronic hepatic porphyria in man caused by halogenated hydrocarbons. In: Strik T.W.A., Koeman J.H., (Eds.), Chémical Porphyria in Man. Elsevier Amsterdam, 1979, p. 3; Peters, H.A., Gocman, A., Cripps, D.J., Bryan, G.T., Dogramaci I. Epidemiology of hexachlorobenzene induced porphyria In Turkey (1982) Arch. Neurol., 39, p. 744
  • Rozman, K., Gorski, J.R., Rozman, P., Parkinson, A., Reduced serum thyroid hormone levels in hexachlorobenzene induced porphyria (1986) Toxicol. Lett, 30, p. 71
  • de Wainstock Calmanovici, R., de Molina M. del Rios, C., Taira de Yamasato, M.C., Tomio, J.M., San Martin de Viale, L.C., Mechanism of hexachlorobenzene induced porphyria in rats. Effect of phenobarbitone pretreatment (1984) Biochem J., 218, p. 753
  • Kleiman de Pisarev, D.L., Sancovich, H.A., Ferramola de Sancovich, A.M., Enhanced thyroxine metabolism in hexachlorobenzene intoxicated rats (1989) J. Endocrinol. Invest., 12, p. 767
  • Smith, A.G., Wrigth, A.L., Cabrai, J.R.P., Influence of hexachlorobenzene on thyroids of male hamsters (1986) Hexachlorobenzene: Proceedings of an International Symposium, p. 357. , C.R., Morris, J.R.P., Cabrai, IARC Scientific publications N° 77, Lyon
  • Lee, Y.P., Lardy, H.A., Influence of thyroid hormones on L-α Gliycerophofiphate dehydrogenases and other dehydrogenases in various organs of the rat (1965) J. Biol. Chem., 240, p. 1427
  • Oppenheimer, J.H., Silva, E., Schwartz, H.L., Surks, M.T., Stimulation of hepatic mitochondrial α-Glycero-phosphate dehydrogenase and malic enzyme by L-Triiodothyronine: characteristics of the response with specific nuclear thyroid hormone binding sites fully saturated (1977) J.Clin. Invest., 59, p. 517
  • Mariash, C.N., Kaiser, F.E., Oppenheimer, J.H., Comparison of the response characteristics of four lipogenic enzymes to 3,5,3’- triiodothyronine administration: Evidence for variable degrees of amplification of the nuclear 3,5,3’triiodothyronine signal (1980) Endocrinology, 106, p. 22
  • Hsu, R.Y., Lardy, H.A., Malic enzyme (1989) Methods in Enzymology, Citric acid cicle Vol. 13, p. 230. , J.M., Lowenstein, Academic Press, New York
  • Bottomley, R.H., Pitot, N.C., Potter, V.R., Morris, N.P., Metabolic adaptations in rat hepatomas v. reciprocal relationship between threonine dehydrase and glucose-6-phosphate dehydrogenase (1963) Cancer Res., 23, p. 400
  • Bradford, M.M., A rapid and sensitive method of quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal. Biochem., 72, p. 248
  • Oppenheimer, J.H., Coulombe, P., Schwartz, H.L., Gutfeld, N.W., Non linear (amplified) relationship between nuclear occupancy by triiodothyronine and the appearance rate of hepatic α-Glycerophosphate dehydrogenase and malic enzyme in the rat (1978) J. Clin. Invest., 61, p. 987
  • Stasilli, N.R., Kroc, R.L., Meltzer, R.I., Antigoitrogenic and calorigenic activities of thyroxine analogues in rats (1959) Endocrinology, 64, p. 62
  • Kleiman de Pisarev, D.L., Rios de Molina M. del, C., San Martin de Viale, L.C., Thyroid function and thyroxine metabolism in hexa-clorobenzene-induced porphyria (1990) Biochem. Pharmacol., 39, p. 817
  • Eelkman Rooda, S.J., Kaptein, E., Rutgers, M., Visser, T.J., Increased plasma 3,5,3’-triiodothyronine sulfate in rats with inhibited type 1 iodothyronine deiodinase activity, as measured by radioimmunoassay (1989) Endocrinology, 124, p. 740
  • van Raaij, J.A.G.M., van den Berg, K.J., Notten, W.R.F., Hexachlorobenzene and its metabolites pentachlorophenol and tetrachlorohydroquinone: interaction with thyroxine binding sites of rat thyroid hormone carriers ex vivo and in vitro (1991) Toxicol. Lett., 59, p. 101
  • van Raaij, J.A.G.M., Kaptein, E., Visser, T.J., van den Berg, J.K., Increased glucuronidation of thyroid hormone in hexachlorobenzene treated rats (1993) Biochem. Pharmacol., 45, p. 627
  • Larsen, P.R., Silva, J.E., Intrapituitary mechanisms in the control of TSH secretion (1983) Molecular Basis of Thyroid Hormone action, p. 351. , J.H., Oppenheimer, H.H., Samuels, Academic Press, New York
  • Kelling, C.K., Menahan, L.A., Peterson, R.E., Hepatic indices of thyroid status in rats treated with 2,3,7,8-tetrachloro dibenzo-p-dioxin (1987) Biochem. Pharmacol., 36, p. 238
  • Roth, W., Voorman, R., Aust, S.D., Activity of thyroid hormone inducible enzymes following treatment with 2,3,7,8-tetrachloro dibenzo-p-dioxin (1988) Toxicol. Appl. Pharmacol., 92, p. 65
  • Motwani, N.M., Unaker, N.J., Roy, A.K., Multiple hormone requirement for the synthesis of α2-microglobulin by monolayers of rat hepatocytes in long term primary culture (1980) Endocrinology, 107, p. 1606
  • Wilson, E.J., Mc. Murray, W.C., Regulation of malic enzyme and mitochondrial α-Glycerophosphate dehydrogenase by thyroid hormones, insulin and glucocorticoids in cultured hepatocytes (1981) J. Biol. Chem., 256, p. 11657

Citas:

---------- APA ----------
de Pisarev, D.L.K., de Sancovich, A.M.F. & Sancovich, H.A. (1995) . Hepatic indices of thyroid status in rats treated with hexachlorobenzene. Journal of Endocrinological Investigation, 18(4), 271-276.
http://dx.doi.org/10.1007/BF03347812
---------- CHICAGO ----------
de Pisarev, D.L.K., de Sancovich, A.M.F., Sancovich, H.A. "Hepatic indices of thyroid status in rats treated with hexachlorobenzene" . Journal of Endocrinological Investigation 18, no. 4 (1995) : 271-276.
http://dx.doi.org/10.1007/BF03347812
---------- MLA ----------
de Pisarev, D.L.K., de Sancovich, A.M.F., Sancovich, H.A. "Hepatic indices of thyroid status in rats treated with hexachlorobenzene" . Journal of Endocrinological Investigation, vol. 18, no. 4, 1995, pp. 271-276.
http://dx.doi.org/10.1007/BF03347812
---------- VANCOUVER ----------
de Pisarev, D.L.K., de Sancovich, A.M.F., Sancovich, H.A. Hepatic indices of thyroid status in rats treated with hexachlorobenzene. J. Endocrinol. Invest. 1995;18(4):271-276.
http://dx.doi.org/10.1007/BF03347812