Artículo
Sopena de Kracoff, Y.E.; Ferramola de Sancovich, A.M.; Sancovich, H.A.; de Pisarev, D.L.K. "Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria" (1994) Journal of Endocrinological Investigation. 17(5):301-305
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Abstract:
The role of thyroid status in hexachlorobenzene (HBC) induced porphyria was studied in normal, thyroidectomized and thyroxine (T4) treated rats. Female Wistar rats were treated with HCB for different periods of time. Serum T4 levels were depressed after 8 days of HCB administration whereas levels of triiodothyronine (T3) were not altered. T4 administered simultaneously with HCB resulted in hyperthyroxinemia. The time course of porphyrinogen carboxy-lyase (PCL) activity in the three HBC treated groups was studied. A rapid and significant decrease of PCL activity was found after 8 days of HCB treatment in T4 treated rats with respect to untreated animals. In contrast, HCB treatment of normal and thyroidectomized rats elicited a significant decrease of PCL activity after 21 and 30 days, respectively. This study shows that thyroid hormone plays an important role in the early establishment of HCB induced porphyria. © 1994, Italian Society of Endocrinology (SIE). All rights reserved.
Registro:
| Documento: | Artículo |
| Título: | Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria |
| Autor: | Sopena de Kracoff, Y.E.; Ferramola de Sancovich, A.M.; Sancovich, H.A.; de Pisarev, D.L.K. |
| Filiación: | Laboratorio de Porfirinas, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Nuñez, Buenos Aires, 1428, Argentina Vidal 2483, 8° B, Buenos Aires, 1428, Argentina |
| Palabras clave: | hexachlorobenzene; porphyria; porphyrinogen carboxy-liase; thyroid status; Thyroxine; hexachlorobenzene; liothyronine; thyrotropin; thyroxine; uroporphyrinogen decarboxylase; animal experiment; animal model; article; controlled study; enzyme activity; female; hyperthyroxinemia; liothyronine blood level; nonhuman; porphyria; rat; thyroidectomy; thyrotropin blood level; thyroxine blood level; Animal; Carboxy-Lyases; Female; Hexachlorobenzene; Porphyria; Rats; Rats, Wistar; Support, Non-U.S. Gov't; Thyroidectomy; Thyroxine; Triiodothyronine |
| Año: | 1994 |
| Volumen: | 17 |
| Número: | 5 |
| Página de inicio: | 301 |
| Página de fin: | 305 |
| DOI: | http://dx.doi.org/10.1007/BF03348984 |
| Título revista: | Journal of Endocrinological Investigation |
| Título revista abreviado: | J. Endocrinol. Invest. |
| ISSN: | 03914097 |
| CAS: | hexachlorobenzene, 118-74-1, 55600-34-5; liothyronine, 6138-47-2, 6893-02-3; thyrotropin, 9002-71-5; thyroxine, 7488-70-2; uroporphyrinogen decarboxylase, 9024-70-8; Carboxy-Lyases, EC 4.1.1.; Hexachlorobenzene, 118-74-1; porphyrinogen carboxy-lyase, EC 4.1.1.-; Thyroxine, 7488-70-2; Triiodothyronine, 6893-02-3 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03914097_v17_n5_p301_SopenadeKracoff |
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Citas:
---------- APA ----------
Sopena de Kracoff, Y.E., Ferramola de Sancovich, A.M., Sancovich, H.A. & de Pisarev, D.L.K. (1994) . Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria. Journal of Endocrinological Investigation, 17(5), 301-305.http://dx.doi.org/10.1007/BF03348984
---------- CHICAGO ----------
Sopena de Kracoff, Y.E., Ferramola de Sancovich, A.M., Sancovich, H.A., de Pisarev, D.L.K. "Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria" . Journal of Endocrinological Investigation 17, no. 5 (1994) : 301-305.http://dx.doi.org/10.1007/BF03348984
---------- MLA ----------
Sopena de Kracoff, Y.E., Ferramola de Sancovich, A.M., Sancovich, H.A., de Pisarev, D.L.K. "Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria" . Journal of Endocrinological Investigation, vol. 17, no. 5, 1994, pp. 301-305.http://dx.doi.org/10.1007/BF03348984
---------- VANCOUVER ----------
Sopena de Kracoff, Y.E., Ferramola de Sancovich, A.M., Sancovich, H.A., de Pisarev, D.L.K. Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria. J. Endocrinol. Invest. 1994;17(5):301-305.http://dx.doi.org/10.1007/BF03348984
