Abstract:
The effect of hexachlorobenzene (HCB) (1 g/kg bw) administration for 4 weeks, on thyroxine (T4) and triiodothyronine (T3) metabolism was studied in Wistar rats. The effect on serum binding of T4 has also been studied. Animals were injected with a tracer dose of either labeled hormone and by examining serum L-125I-T4 and L-125-I-T3, kinetics of radiolabeled hormones metabolism were calculated. The T4 metabolic clearance (MCI) as well as the distribution space, were increased by 6 fold. Decreased serum T4 levels result from an increase both in deiodinative and fecal disposal in HCB-treated rats. 125I-T3 metabolism was slightly affected. The enhanced peripheral disposition of thyroxine appears to lead to increased thyroid function, as measured by augmented TSH serum levels and 125I-thyroidal uptake. Serum binding of T4 was not affected. © 1989, Italian Society of Endocrinology (SIE). All rights reserved.
Registro:
Documento: |
Artículo
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Título: | Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats |
Autor: | Kleiman de Pisarev, D.L.; Sancovich, H.A.; Ferramola de Sancovich, A.M. |
Filiación: | Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos, Aires, Argentina Vidal 2483, 8°B, Buenos Aires, 1428, Argentina
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Palabras clave: | deiodination; hexachlorobenzene; intoxication; thyroid hormones; Thyroxine; triiodothyronine; hexachlorobenzene; liothyronine; radioisotope; thyrotropin; thyroxine; animal experiment; article; deiodination; intoxication; kinetics; metabolic clearance rate; nonhuman; priority journal; rat; Animal; Blood Proteins; Chlorobenzenes; Female; Hexachlorobenzene; Iodine Radioisotopes; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Thyroid Gland; Thyroxine; Triiodothyronine |
Año: | 1989
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Volumen: | 12
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Número: | 11
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Página de inicio: | 767
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Página de fin: | 772
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DOI: |
http://dx.doi.org/10.1007/BF03350056 |
Título revista: | Journal of Endocrinological Investigation
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Título revista abreviado: | J. Endocrinol. Invest.
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ISSN: | 03914097
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CAS: | hexachlorobenzene, 118-74-1, 55600-34-5; liothyronine, 6138-47-2, 6893-02-3; thyrotropin, 9002-71-5; thyroxine, 7488-70-2; Blood Proteins; Chlorobenzenes; Hexachlorobenzene, 118-74-1; Iodine Radioisotopes; Thyroxine, 7488-70-2; Triiodothyronine, 6893-02-3
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03914097_v12_n11_p767_KleimandePisarev |
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Citas:
---------- APA ----------
Kleiman de Pisarev, D.L., Sancovich, H.A. & Ferramola de Sancovich, A.M.
(1989)
. Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats. Journal of Endocrinological Investigation, 12(11), 767-772.
http://dx.doi.org/10.1007/BF03350056---------- CHICAGO ----------
Kleiman de Pisarev, D.L., Sancovich, H.A., Ferramola de Sancovich, A.M.
"Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats"
. Journal of Endocrinological Investigation 12, no. 11
(1989) : 767-772.
http://dx.doi.org/10.1007/BF03350056---------- MLA ----------
Kleiman de Pisarev, D.L., Sancovich, H.A., Ferramola de Sancovich, A.M.
"Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats"
. Journal of Endocrinological Investigation, vol. 12, no. 11, 1989, pp. 767-772.
http://dx.doi.org/10.1007/BF03350056---------- VANCOUVER ----------
Kleiman de Pisarev, D.L., Sancovich, H.A., Ferramola de Sancovich, A.M. Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats. J. Endocrinol. Invest. 1989;12(11):767-772.
http://dx.doi.org/10.1007/BF03350056