Artículo

Kleiman de Pisarev, D.L.; Sancovich, H.A.; Ferramola de Sancovich, A.M. "Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats" (1989) Journal of Endocrinological Investigation. 12(11):767-772
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Abstract:

The effect of hexachlorobenzene (HCB) (1 g/kg bw) administration for 4 weeks, on thyroxine (T4) and triiodothyronine (T3) metabolism was studied in Wistar rats. The effect on serum binding of T4 has also been studied. Animals were injected with a tracer dose of either labeled hormone and by examining serum L-125I-T4 and L-125-I-T3, kinetics of radiolabeled hormones metabolism were calculated. The T4 metabolic clearance (MCI) as well as the distribution space, were increased by 6 fold. Decreased serum T4 levels result from an increase both in deiodinative and fecal disposal in HCB-treated rats. 125I-T3 metabolism was slightly affected. The enhanced peripheral disposition of thyroxine appears to lead to increased thyroid function, as measured by augmented TSH serum levels and 125I-thyroidal uptake. Serum binding of T4 was not affected. © 1989, Italian Society of Endocrinology (SIE). All rights reserved.

Registro:

Documento: Artículo
Título:Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats
Autor:Kleiman de Pisarev, D.L.; Sancovich, H.A.; Ferramola de Sancovich, A.M.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos, Aires, Argentina
Vidal 2483, 8°B, Buenos Aires, 1428, Argentina
Palabras clave:deiodination; hexachlorobenzene; intoxication; thyroid hormones; Thyroxine; triiodothyronine; hexachlorobenzene; liothyronine; radioisotope; thyrotropin; thyroxine; animal experiment; article; deiodination; intoxication; kinetics; metabolic clearance rate; nonhuman; priority journal; rat; Animal; Blood Proteins; Chlorobenzenes; Female; Hexachlorobenzene; Iodine Radioisotopes; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Thyroid Gland; Thyroxine; Triiodothyronine
Año:1989
Volumen:12
Número:11
Página de inicio:767
Página de fin:772
DOI: http://dx.doi.org/10.1007/BF03350056
Título revista:Journal of Endocrinological Investigation
Título revista abreviado:J. Endocrinol. Invest.
ISSN:03914097
CAS:hexachlorobenzene, 118-74-1, 55600-34-5; liothyronine, 6138-47-2, 6893-02-3; thyrotropin, 9002-71-5; thyroxine, 7488-70-2; Blood Proteins; Chlorobenzenes; Hexachlorobenzene, 118-74-1; Iodine Radioisotopes; Thyroxine, 7488-70-2; Triiodothyronine, 6893-02-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03914097_v12_n11_p767_KleimandePisarev

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Citas:

---------- APA ----------
Kleiman de Pisarev, D.L., Sancovich, H.A. & Ferramola de Sancovich, A.M. (1989) . Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats. Journal of Endocrinological Investigation, 12(11), 767-772.
http://dx.doi.org/10.1007/BF03350056
---------- CHICAGO ----------
Kleiman de Pisarev, D.L., Sancovich, H.A., Ferramola de Sancovich, A.M. "Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats" . Journal of Endocrinological Investigation 12, no. 11 (1989) : 767-772.
http://dx.doi.org/10.1007/BF03350056
---------- MLA ----------
Kleiman de Pisarev, D.L., Sancovich, H.A., Ferramola de Sancovich, A.M. "Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats" . Journal of Endocrinological Investigation, vol. 12, no. 11, 1989, pp. 767-772.
http://dx.doi.org/10.1007/BF03350056
---------- VANCOUVER ----------
Kleiman de Pisarev, D.L., Sancovich, H.A., Ferramola de Sancovich, A.M. Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats. J. Endocrinol. Invest. 1989;12(11):767-772.
http://dx.doi.org/10.1007/BF03350056